PRE-REGISTERED
PARTICIPANTS
(as of September 11, 2000)
"*" indicates
abstract submitted by that author
Alexey Agafanov
Institute of Theoretical and Experimental
Biophysics RAS, Moscow
Possible
ways of regulation of mitochondrial KATP channel
Alexander Aleshin
Iowa State University, Ames, IA
* (1)Tetramer
preserved in crystal structures of mammalian hexokinase I may be related
to the oligomeric state of the enzyme in association with the mitochondrial
permeability transition pore
Larisa Andreeva
Northwick Park Institute of Medical
Research, United Kingdom
(56)
CyPD
overexpression in Cos-7 cells
Alexander Andreyev
MitoKor, San Diego, CA
* (2)
Ca2+
uptake and release of cytochrome c in neural cell mitochondria
(29)
Differential
release of cytochrome c and adenylate kinase in response to various apoptotic
triggers
Andreas Antoniou
University of Ottawa, Faculty of
Medicine, Ottawa, Ontario, Canada
Mitochondrial
UCP2 is associated with uncoupled respiration and low radiation-induced
hydrogen peroxide levels in drug resistant leukemic cells
Bruno Antonsson
Serono Pharmaceutical Research
Institute, Geneva, Switzerland
* (3)
Bax
is present as a high molecular weight oligomer/complex in the mitochondrial
membrane of apoptotic cells
Paolo Bernardi
University of Padova, Italy
* (4)
The
mitochondrial permeability transition during chronic feeding with the hepatocarcinogen
2-acetylaminofluorene
(36)
The
relationship between the mitochondrial permeability transition and cell
death
Gisela Beutner
University of Rochester School
of Medicine, Rochester, NY
How
Zinc enters mitochondria?
(45)
Visualization
and modification of the mitochondrial permeability transition pore in stiatal
neurons
Nikolai Brustovetsky
University of Minnesota, Minneapolis,
MN
* (5)
Comparison
of Ca2+- and protein-induced cytochrome c release from brain mitochondria
in vitro and in situ
Jennifer Buckman
University of Pittsburgh, PA
* (6)
Dynamics
of mitochondrial membrane potential in neurons and astrocytes
(42)
Mitochondrial
function in neuronal injury
Linas Buntinas
University of Rochester Medical
Center, Rochester, NY
(17)
A
comparison of the oxidation state of intramitochondrial Mn under conditions
chosen to induce oxidation and between brain, heart, and liver mitochondria
(18)
Measurement
of the oxidation state of manganese inside mitochondria using XANES spectroscopy
Peter Carlen
Toronto Western Hospital Research
Institute, Toronto, Ontario, Canada
Dynamics
of intracellular calcium and free radical production during ischemic injury
in pyramidal neurons
Differential
sensitivity of astrocytes to free radicals: mytochondrial dysfunction
and toxicity
Jane Chisholm
University of Rochester Medical
Center, Rochester, NY
dynamic compartmentationand
signaling
mitochondrial membrane transport
Samantha Clarke
University of Bristol, United Kingdom
* (8)
The
molecular mechanism of the mitochondrial permeability transition pore
Marco Colombini
University of Maryland, College
Park, MD
* (9)
Bcl-xL
alters the gating properties of VDAC channels isolated from rat liver mitochondria
(55)
Topological
orientation of VDAC in mitochondria
Gino Cortopassi
University of California - Davis,
CA
* (10)
Novel
cellular models of mitochondrial neurological disease
Dana Crawford
Albany Medical College, Albany,
NY
Mitochondrial
polynucleotide degradation as an early stage marker of mammalian stress
response
Mary Crivellone
University of Medicine and Dentistry
of New Jersey, Stratford, NJ
chaperone-assisted assembly
of respiratory chain complexes
Elliot Crouser
Ohio State University, Columbus,
OH
Induction
of the permeability transition contributes to mitochondrial injury and
altered respiration during endotoxemia
Jamie Dawson
University of Maryland, College
Park, MD
* (55)
Topological
orientation of VDAC in mitochondria
Yuru Deng
Wadsworth Center, Albany, NY
* (11)
Transition
to cubic morphology of mitochondrial inner membranes in fasting amoeba
may be a response to increased oxygen radical generation
Vito De Pinto
University of Catania, Italy
* (12)
Eukaryotic
porin 3-D prediction by threading on the crystal structures of bacterial
porins
Roman Eliseev
University of Rochester Medical
School, Rochester, NY
* (13)
Dysfunction
of mitochondria and cytochrome c release during apoptosis
(17)
A
comparison of the oxidation state of intramitochondrial Mn under conditions
chosen to induce oxidation and between brain, heart, and liver mitochondria
(18)
Measurement
of the oxidation state of manganese inside mitochondria using XANES spectroscopy
Ove Eriksson
University of Helsinki, Finland
Najeem Folarin
Northwick Park Institute for Medical
Research, Harrow, Middlesex, United Kingdom
* (56)
CyPD
overexpression in Cos-7 cells
Michael Forte
Oregon Health Sciences University,
Portland, OR
(55)
Topological
orientation of VDAC in mitochondria
Kathleen Gabrielson
Johns Hopkins University
3NPA
induces mitochondrial dysfunction in cardiac toxicity in mice
Odile Gateau-Roesch
Lyon-Sud Medical School, Lyon,
France
(28)
Ca2+-binding
properties of long-chain saturated fatty acids and their possible role
in mitochondria
Frank Gellerich
Neurologische Klinik, Halle, Germany
* (15)
Bioenergetic
importance of mitochondrial outer membrane as diffusion barriere under
normal and impaired conditions
Constance Glover
National Institute of Health, Frederick,
MD
apoptosis
Serguei Grigoriev
New York University, New York,
NY
Atan Gross
The Weizmann Institute of Science,
Rehovot, Israel
* (16)
The
role of BID in apoptosis
Karlene Gunter
University of Rochester Medical
Center, Rochester, NY
* (17)
A
comparison of the oxidation state of intramitochondrial Mn under conditions
chosen to induce oxidation and between brain, heart, and liver mitochondria
(18)
Measurement
of the oxidation state of manganese inside mitochondria using XANES spectroscopy
Thomas Gunter
University of Rochester Medical
Center, Rochester, NY
* (18)
Measurement
of the oxidation state of manganese inside mitochondria using XANES spectroscopy
(13)
Dysfunction
of mitochondria and cytochrome c release during apoptosis
(17)
A
comparison of the oxidation state of intramitochondrial Mn under conditions
chosen to induce oxidation and between brain, heart, and liver mitochondria
Gyorgy Hajnoczky
Thomas Jefferson University, Philadelphia,
PA
* (19)
Mitochondrial
Ca2+ signaling in life and death
Andrew Halestrap
University of Bristol, United Kingdom
(8)
The
molecular mechanism of the mitochondrial permeability transition pore
Mary-Ellen Harper
University of Ottawa, Faculty of
Medicine, Ottawa, Ontario, Canada
Mitochondrial
UCP2 is associated with uncoupled respiration and low radiation-induced
hydrogen peroxide levels in drug resistant leukemic cells
Teresa Hastings
University of Pittsburgh, PA
Lihua He
University of North Carolina, Chapel
Hill, NC
* (20)
Characterization
of cyclosporin A sensitive and insensitive permeability transition pores
in rat liver mitochondria
Kaisa Heiskanen
Turku Centre for Biotechnology,
University of Turku and Abo Akademi, Finland
(32)
Mitochondrial
swelling, depolarization, and permeability transition during BAX-induced
apoptosis in hepatocytes
Donald Higgins, Jr.
Ohio State University, Columbus,
OH
Richard Honzatko
Iowa State University, Ames, IA
(1)Tetramer
preserved in crystal structures of mammalian hexokinase I may be related
to the oligomeric state of the enzyme in association with the mitochondrial
permeability transition pore
Francois Ichas
European Institute of Chemistry
and Biology, INSERM E.9929, France
* (21)
The
permeability transition pore signals apoptosis by directing Bax translocation
William Irwin
University of Padova, Padova, Italy
The
role of mitochondria in muscle cell death
Regina Jakob
University of Chicago, Chicago,
IL
On
the nature of cyclosporin neuroprotective effects: the mitochondria
connection
Anna Kicinska
Nencki Institute of Experimental
Biology PAN, Warszawa, Poland
E.
coli expression and purification of human mitochondrial Na+/H+ exchanger
(NHE6)
Kathleen Kinnally
New York University, New York,
NY
Apoptosis
is not triggered in neuronal cells by partial release of cytochrome c by
laser pulses
(7)
Functional
modifications of the protein translocation channel induced by genetic alterations
of the TIM complex
(34)
Death
signal leads to the formation of a novel high-conductance channel in the
mitochondrial outer membrane
(38)
BAX
BH3 peptide induces permeability transition-independent release of cytochrome
c from neural cell but not isolated brain or liver mitochondria
Martin Klingenberg
University of Munich, Germany
* (22)
A
fresh look at uncoupling proteins
Boris Krasnikov
Burke Medical Research Institute,
White Plains, NY
Dietary
restriction protects mitochondria against permeability transition
Bruce Kristal
Burke Medical Research Institute,
White Plains, NY
Zn2+
induces the mitochondrial permeability transition
Dietary
restriction protects mitochondria against permeability transition
John Lemasters
University of North Carolina, Chapel,
Hill, NC
* (24)
Mitochondrial
Ca2+ and reactive oxygen species (ROS) trigger the mitochondrial permeability
transition (MPT) and cell killing after reperfusion of cultured rat hepatocytes
(20)
Characterization
of cytoclosporin A sensitive and insensitive permeability transition pores
in rat liver mitochondria
Tomas Landh
Camurus Lipid Research Foundation,
Lund, Sweden
Christiane Levrat
Lyon-Sud Medical School, Lyon,
France
Phospholipids
reacylation could control the cellular sensitivity to tumor necrosis factor-alpha
cytotoxicity
(28)
Ca2+-binding
properties of long-chain saturated fatty acids and their possible role
in mitochondria
Xiaoxian Li
University of Maryland, College
Park, MD
(9)
Bcl-xL
alters the gating properties of VDAC channels isolated from rat liver mitochondria
Carmen A. Mannella
Wadsworth Center, Albany, NY
* (25)
Dynamics
of mitochondrial inner membrane folding inferred from EM tomography
(11)
Transition
to cubic morphology of mitochondrial inner membranes in fasting amoeba
may be a response to increased oxygen radical generation
Virtual
cell simulations of mitochondrial adenine nucleotide fluxes: role
of organelle morphology in energy output
Ryan Martinus
Technology Development Group, HortResearch
Institute of New Zealand Ltd, Hamilton, New Zealand
Surface
expression of CPN60: implications for neurodegeneration
Roy McCauley
Wayne State University, Detroit,
MI
The
VDAC two-step: a "heel-toe" mechanism for membrane insertion
Gavin McStay
University of Bristol, United Kingdom
(8)
The
molecular mechanism of the mitochondrial permeability transition pore
Simon Melov
Buck Institute for Age Research,
Novato, CA
* (26)
A
mouse model of mitochondrial oxidative stress
Eva Milanesi
University of Padova, Italy
Linda Mills
Toronto Western Hospital, Canada
* (27)
A
decrease in the rate of mitochondrial protein import is an early event
during the initiation of neuronal apoptosis
Galina Mironova
Institute of Theoretical and Experimental
Biophysics RAS, Moscow
* (28)
Ca2+-binding
properties of long-chain saturated fatty acids and their possible role
in mitochondria
Activation
of the mitochondrial KATP channel by UDP
Ion Moraru
University of Connecticut Health
Center, Farmington, CT
Virtual
cell simulations of mitochondrial adenine nucleotide fluxes: role
of organelle morphology in energy output
Anne N. Murphy
MitoKor, San Diego, CA
* (29)
Differential
release of cytochrome c and adenylate kinase in response to various apoptotic
triggers
(2)
Ca2+
uptake and release of cytochrome c in neural cell mitochondria
Mary Murphy
Dalhousie University, Sir Charles
Tupper Medical School, Halifax, Nova Scotia, Canada
* (30)
Surfactant
potentiation of virus-induced mitochondrial disease in acute hepatic encephalopathy
Michael Murphy
University of Otago, Dunedin, New
Zealand
apoptosis/mitochondrial therapies/oxidative
damage
Alexandre Negoda
Institute of Theoretical and Experimental
Biophysics RAS, Moscow, Russia
Activation
of the mitochondrial KATP channel by UDP
David Nicholls
Buck Institute for Age Research,
Novato, CA
* (31)
Mitochondrial
membrane potential in cultured neural cells: distinctive responses
to apoptotic stimuli, NMDA and AMPA receptor activation and modelling with
a 'virtual cell'
Anna-Liisa Nieminen
Case Western Reserve University,
Cleveland, OH
* (32)
Mitochondrial
swelling, depolarization, and permeability transition during BAX-induced
apoptosis in hepatocytes
(39)
Multiple
kinetics of mitochondrial cytochrome c release in apoptosis
Debkumar Pain
University of Pennsylvania School
of Medicine, Philadelphia, PA
* (33)
Functional
relationships between YFH1P and SSQ1P: proteins participating in
mitochondrial iron homeostasis
Evgeny Pavlov
New York University, New York,
NY
* (34)
Death
signal leads to the formation of a novel high-conductance channel in the
mitochondrial outer membrane
Peter Pennefather
University of Toronto, Toronto,
Ontario, Canada
Differential
sensitivity of astrocytes to free radicals: mytochondrial dysfunction
and toxicity
Guy Perkins
University of California - San
Diego, La Jolla, CA
* (35)
Dual-specific
A kinase anchoring proteins target mitochondria
(39)
A
thermodynamic model to predict the folding of the inner membrane of mitochondria
Patrice Petit
Institut Cochin de Genetique Moleculaire,
France
(54)
On
the evolutionary conservation of the cell death machinery: involvement
of an apoptosis inducing factor homolog in Dictyostelium discoideum cell
death
Valeria Petronilli
CNR Unit for Biomembranes and Dept.
of Biomedical Sciences, Padova, Italy
* (36)
The
relationship between the mitochondrial permeability transition and cell
death
Douglas Pfeiffer
Ohio State University, Columbus,
OH
Induction
of the permeability transition contributes to mitochondrial injury and
altered respiration during endotoxemia
(25)
Dynamics
of mitochondrial inner membrane folding inferred from EM tomography
Peter Polcic
Comenius University, Bratislava,
Slovak Republic
* (37)
The
biogenesis of mitochondria as a possible target for cytotoxic action of
bax in yeast cells
Brian Polster
University of Maryland School
of Medicine, Baltimore, MD
* (38)
BAX
BH3 peptide induces permeability transition-independent release of cytochrome
c from neural cell but not isolated brain or liver mitochondria
Jochen Prehn
University of Muenster, Germany
* (39)
Multiple
kinetics of mitochondrial cytochrome c release in apoptosis
Muriel Priault
IBGC/CNRS, Bourdeaux, France
Bax
pro-apoptotic function requires oxygen
Frederick Prince
Plymouth State College, NH
* (40)
A
revised look at mitochondrial cristae morphology in steroid producing cells:
diversity of form of cristae from human Leydig cells from birth to puberty
Christian Renken
San Diego State University, CA
* (41)
A
thermodynamic model to predict the folding of the inner membrane of mitochondria
Ian J. Reynolds
University of Pittsburgh, PA
* (42)
Mitochondrial
function in neuronal injury
(49)
Mechanisms
of ROS generation by rat brain mitochondria
(6)
Dynamics
of mitochondrial membrane potential in neurons and astrocytes
Tatiana Rostovtseva
University of Maryland, College
Park, MD
Bax
samples did not change the properties of VDAC channels but stimulated their
insertion
James Russell
National Institutes of Health,
Bethesda, MD
* (43)
Mitochondria
regulate Ca2+ wave propagation in oligodendrocyte precursor cells
Uwe Schlattner
Swiss Fed. Inst. Technol. TH-Zurich,
Switzerland
* (51)
Mitochondrial
creatine kinase: involvement in energy channeling and control of
permeability transition
Luca Scorrano
Dana Farber Cancer Institute, Boston,
MA
* (44)
p15
BID oligomerizes mitochondrial BAK and alters mitochondrial physiology
to amplify cytochrome c release
(36)
The
relationship between the mitochondrial permeability transition and cell
death
Shey-Shing Sheu
University of Rochester School
of Medicine, Rochester, NY
* (45)
Visualization
and modification of the mitochondrial permeability transition pore in stiatal
neurons
How
Zinc enters mitochondria?
Yasuo Shinohara
University of Tokushima Shomachi-1,
Tokushima, Japan
* (46)
Why
do mitochondria from tumor cells show higher capability for hexokinase
binding than those from normal liver?
Varda Shoshan
Ben Gurion University of the Negev,
Beer Sheva, Israel
Calcium
binding and translocation by VDAC as a possible regulatory mechanism in
mitochondrial function
Keshav Singh
John Hopkins Oncology Center, Baltimore,
MD
Roxanne Sperry
New York Medical College, Hawthorne,
NY
* (47)
Signals
from mitochondria play a role in the regulation of the cell cycle in tumor
cells
Anatol Starkov
University of Maryland, Baltimore,
MD
On
the mechanisms of reactive oxygen species production by rat heart and brain
mitochondria relevant to ischemia/reperfusion injury
Jelena Stevanovic-Popovic
National Institutes of Health,
Bethesda, MD
Amandip K. Utal
University of Rochester, NY
mitochondria in neuronal processes
and neurodegeneration
Govind Vatassery
VA Medical Center, Minneapolis,
MN
* (48)
Brain
mitochondrial respiration and vitamin E are altered by treatment with peroxynitrite
Tanya Votyakova
University of Pittsburgh, PA
* (49)
Mechanisms
of ROS generation by rat brain mitochondria
(42)
Mitochondrial
function in neuronal injury
Yau-Huei Wei
National Yan-Ming University, Taipei,
Taiwan
* (52)
Molecular
basis for the increase of mitochondrial mass and mitochondrial DNA in response
to oxidative stress in human cells
Yvonne Will
MitoKor, San Diego, CA
A
systematic approach to study mitochondrial dysfunction in cybrids
Antje Zapf-Colby
MitoKor, San Diego, CA
* (53)
Functional
characterization of human voltage-dependent anion channel 1 (HVDAC1) in
SH-SY5Y cells
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