PROGRAM 2nd Albany Conference Frontiers of Mitochondrial Research September 24-27, 1998 Rensselaerville, NY THURSDAY EVENING - 7:30 PM Carmen Mannella Wadsworth Center President, Albany Conference Foundation Welcoming Remarks Our Changing Views of Mitochondria FRIDAY MORNING Permeability Transition 9:00 AM Robert Haworth University of Wisconsin Clinical Science Center Interaction between the ADP/ATP translocase and the Ca-activated non-specific channel of the mitochondrial inner membrane: what the reviewers didn't want you to see 9:30 AM Andrew Halestrap University of Bristol Cyclosporin-sensitive binding of purified mitochondrial cyclophilin to the adenine nucleotide translocase: Implications for the mechanism of the permeability transition 10:00 AM Dieter Brdiczka University of Konstanz The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition 10:30 AM BREAK 11:00 AM Eric Fontaine Universite J. Fourier, France Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain Complex I 11:30 AM Ian Reynolds University of Pittsburgh An evaluation of the role of permeability transition in excitotoxic neurodegeneration FRIDAY AFTERNOON 2:00-4:00 PM Workshop(s) FRIDAY EVENING Calcium 7:15 PM David Nicholls University of Dundee, Scotland Mitochondrial control of acute excitotoxicity in cultured cerebellar granule cells 7:45 PM Gyorgy Hajnoczky Thomas Jefferson University Local calcium control between IP3 receptors and mitochondria 8:15 PM BREAK 8:30 PM Shey-Shing Sheu University of Rochester School of Medicine Cross talk between sarcoplasmic reticular and mitochondrial Ca++ in rat ventricular myocytes 9:00 PM François Ichas University of Padova, Italy From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low to high conductance state SATURDAY MORNING Apoptosis 9:00 AM Alexander Andreyev University of Maryland Two pathways of Ca2+-induced cytochrome c release from mitochondria 9:30 AM Anne Murphy MitoKor BCL-2 inhibition of mitochondrial cytochrome c release in neural cell apoptosis 10:00 AM Atan Gross Washington University at St. Louis TNF and Fas induce caspase cleavage of cytosolic BID resulting in its targeting mitochondria and releasing cytochrome c 10:30 AM BREAK 11:00 AM Kathleen Kinnally Wadsworth Center Investigations into the role of mitochondria and their channels in apoptosis 11:30 AM Soraya Smaili National Institutes of Health Mitochondrial membrane potential changes in cell death induction in the presence of the pro-apoptotic factor Bax SATURDAY AFTERNOON 2:00-4:00 PM Workshop(s) SATURDAY EVENING Visualizing Mitochondrial Events 7:15 PM Jörg Hüser Loyola University Repetitive gating of the permeability transition pore in single mitochondria in vitro and in the living cell 7:45 PM Chris Fall University of California, Davis Visualization of cyclical mitochondrial depolarizations in cell culture 8:15 PM BREAK 8:30 PM Genevieve Sparagna University of Texas Health Science Center-Houston Fatty acid-induced apoptosis in cultured rat neonatal cardiomyocytes is associated with early mitochondrial membrane potential changes and onset of the permeability transition 9:00 PM Ion Moraru University of Connecticut Health Center Imaging pH in single mitochondria of living cells SUNDAY MORNING Carriers, Channels and Receptors 9:00 AM Maureen McEnery Case Western Reserve University The role of the mitochondrial benzodiazepine receptor in apoptotic signaling 9:30 AM Keith Garlid Oregon Graduate Institute The role of mitochondrial KATP channels in cardiac ischemia and in normal heart function 10:00 AM Marco Colombini University of Maryland A current working model for the structural changes that occur during voltage gating in VDAC 10:30 AM Frederic Bouillaud Ceremod, CNRS, France Uncoupling proteins 11:00 AM Closing Discussion For further information contact...Carmen Mannella: carmen@wadsworth.org