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The Rieder Lab: Studies on Mitosis and the Cell Cycle


Conly Rieder's Laboratory


Yang, Z., U.S. Tulu, P. Wadsworth and C.L. Rieder. 2007. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Current Biology 17:973-980.

Taylor, S.S., K.G. Hardwick, K.E. Sawin, S. Biggins, S. Piatti, A. Khodjakov, C.L. Rieder, E.D. Salmon and A. Musacchio. 2007. Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science 316:982b.

Magidson, V., J. Loncaret, Pl. Hergert, C.L. Rieder and A. Khodjakov. 2007. Laser microsurgery in the GFP-era: a cell biologist's perspective. Methods in Cell Biology 82:239-266.

Ban, K.H., J.Z. Torres, J. J. Miller, A. Mikhailov, M.V. Nachury, J.J. Tung, C.L. Rieder and P.K. Jackson. 2007. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Developmental Cell 13:29-42.


Rieder, C.L. 2006. "Mitosis". In "McGraw-Hill Encyclopedia of Science and Technology. 10th edition". Pp. 273-278

Rieder, C.L. 2006. "Mitosis". Chapter 10 in the Textbook "Cells", B. Lewin, L. Cassimeris, V.R. Lingappa, and G. Plopper, Eds. Jones and Bartlett, Boston. pp 438-487.

Pereira, A.L., A.J. Pereira, A.R.R. Maia, K. Drabek, C.L. Sayas, P.J. Hergert, M. Lince-Faria, I. Matos, C. Duque, T. Stephanova, C.L. Rieder, W.C. Earnsahw, N. Galjart and H. Maiato. 2006. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol. Biol. Cell 17:4526-4542.

Maiato, H., P.J. Hergert, S. Moutinho-Pereira, Y. Dong, K.J. VandenBeldt, C.L. Rieder and B.F. McEwen. 2006. The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somatic cells. Chromosoma 115:469-480.

Khodjakov, A. and C.L. Rieder. 2006. Imaging the division process in living tissue culture cells. Methods 38:2-16.

Shinohara, M., A.V. Mikhailov, J.A. Aguirre-Ghisho and C.L. Rieder. 2006. ERK1/2 activity is required in mammals during early G2 for normal cell cycle progression but not during the G2/M or M/A transitions. Molecular Biology of the Cell 17:5227-5240.

Brito, D. and C.L. Rieder. 2006. Mitotic exit in the presence of kinetochore-associated BubR1, Mad1 and Mad2. Current Biology 16:1194-1200.


Maiato, H., A. Khodjakov and C.L. Rieder. 2005. MAST/Orbit is required for the maintenance of kinetochore fibers by regulating tubulin incorporation at microtubule plus ends. Nature Cell Biology 7:42-47.

Rieder, C.L. 2005. Kinetochore fiber formation in animal somatic cells: dueling mechanisms come to a draw. Chromosoma 114:310-318.

Khodjakov, A. and C.L. Rieder. 2005. Imaging the division process in living tissue culture cells. Methods 38:2-16.


Yu, J., S. L. Flemming, B. Williams, E.V. Williams, L. ZeZiao, P. Somma, C.L. Rieder and M.L. Goldberg. 2004. Greatwall kinase is required for proper chromosome condensation and mitotic progression in Drosophila. J. Cell Biol. 164:487-492.

Rieder, C.L. and A. Mikhailov. 2004. The pulse of mitosis. Nature Biotech. 22: 279-280. (A News and Views).

Khodjakov, A., C. Rieder, C.A. Mannella and K.W. Kinnally. 2004. Laser micro-irradiation of mitochondria: is there an amplified mitochondrial death signal in neural cells. Mitochondrion 3:217-227.

Morrison, C. and C.L. Rieder. 2004. Chromosome damage and progression into and through mitosis in vertebrates. DNA Repair 3:1133-1139.

Khodjakov, A. and C.L. Rieder. 2004. A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates. In Nigg, E.A. (Ed.) Centrosomes in Development and Disease, Wiley-VCH, Weinheim, pp 191-210.

Mikhailov, A., M. Shinohara and C.L. Rieder. 2004. Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway. J. Cell Biol., 166:517-526.

Sluder, G., E.H. Hinchcliffe and C.L. Rieder. 2004. The progression and regulation of mitotic events. In "Cell Cycle and Growth Control: Biomolecular Regulation and Cancer". G. Stein and A. Pardee, Eds. John Wiley and Sons Inc., N.Y., N.Y. pp 201-234.

Rieder, C.L. and H. Maiato. 2004. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Developmental Cell 7:637-651.

Mikhailov, A., Shinohara, M. and C.L. Rieder. 2004. The p38-mediated stress-activated checkpoint: a rapid response system for delaying progression through antephase and entry into mitosis. Cell Cycle (in press)


Rieder, C.L. and A. Khodjakov. 2003. Mitosis through the microscope: advances in seeing inside live dividing cells. Science 300:91-96.

Hauf, S., R.W. Cole, S. LaTerra, C. Zimmer, G. Schnapp, R. Walter, A. Heckel, J. van Meel, C.L. Rieder and J-M. Peters. 2003. The small molecule Hesperadin reveals a role for aurora-B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkppoint. J. Cell Biol. 161:281-294.

Maiato, H., E.A.L. Fairley, C.L. Rieder, J.R. Swedlow, C.E. Sunkel and W.C. Earnshaw. 2003. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Cell 113:891-904.

Maiato, H., C.L. Rieder, W.C. Earnshaw and C.E. Sunkel. 2003. How do kinetochores CLASP microtubules? Cell Cycle 2:511-514.

Fleming, S.L. and C.L. Rieder. 2003. Flattening Drosophila cells for high-resolution light microscopic studies of mitosis in vitro. Cell Motil. Cytoskel., 56:141-146.


Mikhailov, A. and C.L. Rieder. 2002. Stressed out of mitosis. Cur. Biol. 12:R331-R333.

Rieder, C.L. 2002. Mitosis. McGraw Hill Encyclopedia of Science and Technology. 9th Edition. McGraw Hill, N.Y., N.Y. Vol. 11:263-268.

Faruki, S., R. W. Cole and C.L. Rieder. 2002. Separating centrosomes interact in the absence of associated chromosomes during mitosis in cultured vertebrate cells. Cell Motil. Cytoskel., 52:107-121.

Savoian, M. and C.L. Rieder. 2002. Mitosis in primary cultures of Drosophila melanogaster larvae neuroblasts. J. Cell Sci., 115:34061-3072.

Rieder, C.L. and R.W. Cole, R.W. 2002. Cold shock and the mammalian cell cycle. Cell Cycle 1:169-175

Khodjakov, A., C.L. Rieder, G. Sluder, G. Cassels, O. Sibon and C-L. Wang. 2002. De novo formation of centrosomes in vertebrate cells arrested during S phase. J. Cell Biol. 158:1171-1181.

Mikhailov, A., R.W. Cole and C.L. Rieder. 2002. DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Cur. Biol., 12:1797-1806.

LaFountain, J.R. Jr., R.W. Cole and C.L. Rieder. 2002. Polar ejection forces are operative in crane-fly spermatocytes, but their action is limited to the spindle periphery.Cell Motility and the Cytoskeleton 51:16-26.

LaFountain, J.R. Jr., R.W. Cole, and C.L. Rieder. 2002. Partner telmoeres during anaphase in crane-fly spermatocytes are connected by an elastic tether that exerts a backward force and resists poleward motion. J. Cell Sci. 115:1541-1549.


Khodjakov, A. and C.L. Rieder. 2001. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153:237-242.

LaFountain, J.R., Jr. R. Oldenbourg, R.W. Cole and C.L. Rieder. 2001. Microtubule flux mediates poleward motion of acentric chromosomes fragments during meiosis in insect spermatocyets. Mole. Biol. of the Cell. 12:4054-4064.

Howell, B.J., B.F. McEwen, J.C. Canman, D.B. Hoffman, E.M. Farrar, C.L. Rieder and E.D. Salmon. 2001. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. of Cell Biol. 155:1159-1172.


Khodjakov, A., R. W. Cole, B.R. Oakley and C.L. Rieder. 2000. Centrosome-independent mitotic spindle formation in vertebrates. Current Biology 10:59-67.

Piel, M., P. Meyer, A. Khodjakov, C.L. Rieder and M. Bornens. 2000. The respective contributions of the mother and daughter centrioles to centrosomes activity and behavior in vertebrate cells. J. Cell Biol. 149:317-329.

Rieder, C.L., R. Cole. 2000. Microtubule disassembly delays the G2-M transition in vertebrates. Current Biology 10:1067-1070.

Savoian, M.S., M.L. Goldberg and C.L. Rieder. 2000. The rate of poleward chromosomes motion is attenuated in Drosophila zw10 and rod mutants. Nature Cell Biology 2:948-952.


Savoian, M.S., W.C. Earnshaw, A. Khodjakov, and C.L. Rieder. 1999. Cleavage furrows formed between centrosomes lacking an intervening spindle and chromosomes contain microtubule bundles, INCENP, and CH01 but not CENP-E. Mol. Biol. of the Cell 10:297-311.

Khodjakov, A., I.S. Gabashvili, and C.L. Rieder.1999. "Dumb" versus "Smart" kinetochore models for chromosome congression during mitosis in vertebrate somatic cells. Cell Motility and the Cytoskeleton. 43:179-185.

Rieder, C.L. and R. Cole. 1999. COMMENTARY: Chromatid cohesion during mitosis:lessons from meiosis. J. Cell Sci. 112:2607-2613.

Khodjakov, A. and C.L. Rieder. 1999. The sudden recruitment of g-tubulin to the centrosomes at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. J. Cell Biol. 146:585-596.

Savoian, M.S., A. Khodjakov and C.L. Rieder. 1999. Unilateral and wandering furrows during mitosis in vertebrates: implications for the mechanism of cytokinesis. Cell Biol. Inter. 23:805-812.


Hinchcliffe, E.H., G.O. Cassels, C.L. Rieder and G. Sluder. 1998. The coordination of centrosomes reproduction with nuclear events of the cell cycle in the sea urchin zygote. J. Cell Biol. 140:1417-1426.

Rieder, C.L. and E.D. Salmon. 1998. The vertebrate cell kinetochore and its roles during mitosis. Trends in Cell Biology. 314-318.

Schackenberg, B.J., A. Khodjakov and C.L. Rieder, and R. E. Palazzo. 1998. The disassembly and reassembly of functional centrosomes in vitro. Proc. Natl. Acad. Sci. 95:9295-9300.

Rieder, C.L. and R. W. Cole.1998. Entry into mitosis in vertebrate somatic cells in guarded by a chromosome damage checkpoint the reverses the cell cycle when triggered during early but not late prophase.J. Cell Biol. 142:1013-1022.

Bobinnec, Y. A. Khodjakov, L.M. Mir, C.L. Rieder, B. Edde, and M. Bornens. 1998. Centriole disassembly in vivo and its effect on centrosome structure and function in vertebrate cells. J. Cell Biol. 143:1575-1589.

McEwen, B.F., C-E. Hsieh, A.L. Mattheyses, and C.L. Rieder. 1998. A new look at kinetochore structure in vertebrate somatic cells using high-pressure freezing and freeze substitution.Chromosoma 107:366-375.

Welcome: The Rieder Lab