RESEARCH INTERESTS
"Investigations into the Modes and Causes of Human Disease" We use both animal model systems, humans as experimental subjects and analysis of human illness databases to elucidate the mechanistic basis and distribution of various human diseases. In past years the focus has been primarily on neurobiology, and that remains a component of the laboratory activity through electrophysiologic study of rodent brain slices, growth of cultured neurons and study of acutely dissociated neurons by flow cytometry. These studies continue, geared particularly at study of factors involved in neurodegenerative diseases, such as Alzheimer's. We also have explored receptors for neurotransmitter substances on thymocytes and human lymphocytes, and perturbation of these actions by environmental contaminants. Recent studies have expanded to explore relationships in humans between physiologic, toxicologic and sociologic factors leading to such diseases as diabetes, cardiovascular disease, thyroid disease and diseases of the respiratory system. In some of these studies we obtain medical information, blood or urine for clinical chemistry indicators and for levels of environmental contaminants (PCBs, pesticides, radioactivity, etc.) in order to determine relationships between behavior and/or exposure and development of disease. In other studies we utilize state datasets for birth, death or hospitalization in order to correlate factors such as place of residence in relation to proximity to waste sites or socioeconomic class with rates of disease in the whole population. Recent investigations have focused on air pollution, especially particulate air pollution, and human disease, using state datasets for study of events such as 9/11.
References:
Ozcan M, Yilmaz B and Carpenter DO (2006) Effects of melatonin on synaptic transmission and long term potentiation in two areas of mouse hippocampus. Brain Res 1111: 90-94.
Ma J, Kouznetsova M, Lessner L and Carpenter DO. (2007) Asthma and infectious respiratory disease in children - correlation to residence near hazardous waste sites. Paediatr Respir Rev 8: 292-298.
Codru N, Schymura MJ, Negoita S, Akwesasne Task Force on the Environment, Rej R and Carpetner DO (2007) Diabetes in relation to serum levels of polychlorinated biphenyls (PCBs) and chlorinated pesticides in adult Native Americans. Environ Health Perspect 115: 1442-1447.
Goncharov A, Haase RF, Santiago-Rivera A, Morse G, Akwesasne Task Force on the Environment, McCaffrey RJ, Rej R and Carpenter DO.(2008) High serum PCBs are associated with eelvation of serum lipids and cardiovascular disease in a Native American population. Environ Res doi:10.1016/j.envres.2007.10.006.
Parrish RR, Horstwood M, Arnason JG, Chenery S, Brewer T, Lloyd NS and Carpenter DO (2008) Depleted uranium contamination by inhalation exposure and its detection after approximately 25 years: Implciation for health assessment. Sci Total Environ 390: 58-68.
Selected Publications - (304 peer reviewed articles, 4 books, 40 reviews and book chapters).
Foran, J.A., Carpenter, D.O., Hamilton, M.C., Knuth, B.A. and Schwager, S.J. Risk-based consumption advice for farmed Atlantic and wild Pacific salmon contaminated with dioxins and dioxin-like compounds. Environ. Health Perspect. 113: 552-556, 2005.
Carpenter, D.O., DeCaprio, A.P., O=Hehir, D., Akhtar, F., Johnson, G., Scrudato, R.J., Apatiki, L., Kava, J., Gologergen, J., Miller, P.K. and Eckstein, L. Polychlorinated biphenyls in serum of the Siberian Yupik people from St. Lawrence Island, Alaska. Int. J. Circumpolar Health, 64(4): 322-335, 2005.
Foran, J.A., Good, D.H., Carpenter, D.O., Hamilton, M.C., Knuth, B.A. and Schwager, S.J. Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. J. Nutr 135: 2639-2643, 2005.
Huang, X., Hites, R.A., Foran, J.A., Hamilton, C., Knuth, B.A.,Schwager, S.J. and Carpenter, D.O. Consumption advisories for salmon based on risk of cancer and non-cancer health effects. Environ. Res., 101: 263-274, 2006.
Shcherbatykh, I., Huang, X., Lessner, L. and Carpenter, D.O. Hazardous waste sites and stoke in New York State. Environ. Health, 4:18, 2005.
Hamilton, M.C., Hites, R.A., Schwager, S.J., Foran, J.A., Knuth, B.A. and Carpenter, D.O. Lipid composition and contaminants in farmed and wild salmon. Environ. Sci. Tech., 39: 8622-8629, 2005.
Yilmaz, B., Sandal, S., Chen, C-H. and Carpenter, D.O. Effects of PCB 52 and PCB 77 on cell viability, [Ca2+]i levels and membrane fluidity in mouse thymocytes. Toxicology, 217: 184-193, 2006.
Tan, Y., Hori, N., and Carpenter, D.O. Electrophysiological effects of three groups of glutamate metabotropic receptors in rat piriform cortex. Cell. Molec. Neurobiol., 26: 915-924, 2006.
Boldyrev, A.A., Carpenter, D.O. and Johnson, P.A., Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems. J. Neurochem., 95: 913-918, 2005.
Sandal, S., Yilmaz, B., Godekmerdan, A., Kelestimur, H. and Carpenter, D.O. Effects of PCBs 52 and 77 on Th1/Th2 balance in mouse thymocyte cell cultures. Immunopharmacol. Immununotoxicol. 27: 601-613, 2005.
Carpenter, D.O. Environmental contaminants and learning and memory. International Congress Series, 1287: 185-189, 2006.
Carpenter, D.O. Polychlorinated biphenyls (PCBs): Routes of exposure and effects on human health. Rev. Environ. Health, 21(1): 1-23, 2006.
Huang, X., Lessner, L. and Carpenter, D.O. Exposure to persistent organic pollutants and hypertensive disease. Environ. Res., 102: 101-106, 2006.
Carpenter, D.O., El-Qaderi, S., Fayzieva, D., Gilani, A., Hambartsumyan, A., Herz, K., Isobaev, M., Kasymov, O., Kudyakov, R., Majitova, Z., Mamadov, E., Nemer, L., Revich, B., Stege, P., Suk, W., Upshur, R., Yilmaz, B. and Zaineh K. Children's environmental health in Central Asia and the Middle East. Int. J. Occup. Environ. Health, 12: 362-368, 2006.
King, W.M., Sarup, V., Sauve, Y., Moreland, C.M., Carpenter, D.O. and Sharma. S.C. Expansion of visual receptive fields in experimental glaucoma. Visual Neurosci. 23: 137-142, 2006.
Tuneva, J., Chittur, S., Boldyrev, A.A., Birman, I. and Carpenter, D.O. Cerebellar granule cell death induced by aluminum. Neurotox. Res., 9: 297-304, 2006.
Trasande, L., Boscarino, J., Graber, N., Falk, R., Schechter, C., Dunkel, G., Geslani, J., Moline, J., Kaplan-Liss, E., Miller, R.K., Korfmacher, K., Carpenter, D., Balk, S.J., Laraque, D., Frumkin, H. and Landrigan, P.J. The environment in pediatric practice: A study of New York pediatricians' attitudes, beliefs, and practices towards children's environmental health. J. Urban Health, 2006, DOI: 10.1007/s11524-006-9071-4.
Surdu, S., Montoya, L.D., Tarbell, A. and Carpenter, D.O. Childhood asthma and indoor allergens in Native Americans in New York. Environ. Health: A Global Access Science Source, 5:22, 2006. DOI: 10.1186/1476-069X-5-22.
Ozcan M., Yilmaz, B. and Carpenter, D.O. Effects of melatonin on synaptic transmission and long term potentiation in two areas of mouse hippocampus. Brain Res., 1111: 90-94, 2006.
Shaw, S.D., Brenner, D., Berger, M.L., Pulser, E.L., Carpenter, D.O., Hong, C-W and Kannan K. PCBs, dioxin-like PCBs, dioxins, and organochlorine pesticides in farmed salmon (Salmo salar) from Maine and Eastern Canada. Environ. Sci. Technol. 40: 5347-5354, 2006.
Yilmaz, B., Ssempebwa J., Mackerer, C.R., Arcaro, K.F. and Carpenter, D.O. Effects of polycyclic aromatic hydrocarbon-containing oil mixtures on generation of reactive oxygen species and cell viability in MCF-7 breast cancer cells. J. Toxicol. Environ. Health, Part A: 70: 1-8, 2007.
Kouznetsova, M., Huang, X., Ma, J., Lessner, L. and Carpenter, D.O. Increased rate of hospitalization for diabetes and residential proximity of hazardous waste sites. Environ. Health Perspect., 115:75-79, 2007.
Yilmaz, Y., Seyran, A.D., Sandal, S., Aydin, M., Colakoglu, N., Kocer, M. and Carpenter, D.O. Modulatory effects of Aroclors 1221 and 1254 on bone turnover and vertebral histology in intact and ovariectomized rats. Toxicology Letts., 166: 276-294, 2006.
Shcherbatykh, I. and Carpenter, D.O. The role of metals in the etiology of Alzheimer's disease. J. Alzheimer's Dis., 11: 191-205, 2007.
Surdu S, Neamtiu I, Gurzau E, Kasler I and Carpenter D. Blood lead levels and hand lead contamination in children ages 4-6 in Copsa Mica, Romania. In: Environmental Health in Central and Eastern Europe. KC Donnelly and LH Cizmas, Eds. Springer Netherlands. pp. 123-134, 2007.
Carpenter D.O. The importance of the Great Lakes Water Quality Agreement. J Public Health Policy 28: 216-220, 2007. Codru N, Schymura MJ, Negoita S, the Akwesasne Task Force on the Environment, Rej R and Carpenter DO. Diabetes in relation to serum levels of polychlorinated biphenyls (PCBs) and chlorinated pesticides in adult Native Americans. Environ Health Perspect. 115: 1442-1447, 2007.
Hennig B, Ormsbee L, Bachas L, Silverstone A, Mlner J, Carpenter D, Thompson C and Suk WA . Introductory comments: nutrition, environmental toxins and implications in prevention and intervention of human diseases. J Nutrit Biochem 189: 161-163, 2007.
Arnold R, Armour MA, Barich J, Cebrian M, Cifuentes L, Kirk D, Koh D, Lewis ND, Ling B, Makalinao I, Maiden T, Paz-y-Mino C, Peralta G, Singh K, Sly P, Suk W, Woodward A, Zheng B and Carpenter DO. Threats to human health and environmental sustainability in the Pacific Basin: The 11th International Conference of the Pacific Basin Consortium. Environ Health Perspect, 115: 1770-1775.
Parrish RR, Horstwood M, Arnason JG, Chenery S, Brewer T, Lloyd NS and Carpenter DO. Depleted uranium contamination by inhalation exposure and its detection after approximately 25 years: Implications for health assessment. Sci Total Environ 390: 58-68, 2008.
Goncharov A, Haase RF, Santiago-Rivera A, Morse G, Akwesasne Task Force on the Environment, McCaffrey RJ, Rej R and Carpenter DO. High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population. Environ Res, In press. doi:10.1016/j.envres.2007.10.006
Ma J, Kouznetsova M, Lessner L and Carpenter DO. Asthma and infectious respiratory disease in children - correlation to residence near hazardous waste sites. Paediatr Respir Rev 8: 292-298, 2007.
