Slide 008: Diagnosis: sickle cell anemia Available data: 20 year- old male. Prominent findings in this case were sickle cells, target cells, and Howell-Jolly bodies. Twenty-two percent (22%) of the participating laboratories failed to recognize the presence of Howell-Jolly bodies. Howell-Jolly bodies are round blue-black inclusions of red blood cells seen on Wright-stained smears. They are nuclear fragments of condensed DNA, normally removed by the spleen, but appearing in severe hemolytic anemias, in patients with dysfunctional spleens or after splenectomy. The responses for band neutrophils and segmented neutrophils were combined and graded as total neutrophils.   Go to Slide 008 statistics database Return to February 1998 Cytohematology Glass Slide Event

Laboratory Data WBC 15.0 X 109/ L RBC 2.20 X 1012/ L Hemoglobin 7.5 g/dL Hematocrit 21.3 % MCV 96.8 fL MCH 34.1 pg MCHC 35.2 g/dL Platelet 270 X 109 / L