Basophilic stippling

These four images were taken from the March 1997 Cytohematology Proficiency Test Event - Slide 003. All four images show red cells with basophilic stippling. Basophilic stippling is present as many course blue-purple staining granules within the red blood cell. The particles are precipitated ribosomal protein (RNA) seen in lead poisoning, severe bacterial infection, drug exposure, alcoholism, anemias with impaired hemoglobin synthesis, megaloblastic anemia, and refractory anemia.

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