Through the Microscope: Blood Cells - Life's Blood

Hairy cell leukemia

Hairy cell leukemia, or leukemic reticuloendotheliosis, is a rare malignant disorder. It usually occurs in middle-aged patients over 50. The first symptoms of disease include weakness and lethargy. Enlarged spleen occurs in 80% of patients.

Hairy cells are characterized by their fine, irregular pseudopods and immature nuclear features. Bone marrow aspiration is often unsuccessful because of complete infiltration by hairy cells, resulting in a dispersed spongy web of cells in an increased meshwork of reticulin fiber.