Main Body

Through the Microscope: Blood Cells - Life's Blood

Spherocytes

Spherocytes are red blood cells that are almost spherical in shape. They have no area of central pallor like a normal red blood cell. Large spherocytes (macrospherocytes) are seen in hemolytic anemia. Small spherocytes (microspherocytes) are sometimes seen in severe burn cases.

A variety of spherical forms are seen in hereditary spherocytosis. The cells depicted in this image are from a patient with hereditary spherocytosis.