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|Department of Health

Smart Lighting Center

Smart Lighting Center

Revolutionizing Light Microscopy

Bio-imaging Team
Research: Focus and Benefits; Timeline
Image Technology: Imaging Modalities
in Light Microscopy; Impact of LEDs on
Transmitted Light
Imaging; Impact of LEDs on
Fluorescent Imaging; Test bed for
Active Illumination; Automated Screening

Imaging modalities in light microscopy

Two imaging modalities:

Transmitted: white light
Fluorescence: Broad spectrum

Transmitted: white light

absorbents stains
non-destructive contrast

Live cell imaging

DIC image of a PtK cell

Automated scanning of histology/biopsy

Mouse intestine (H&E) stain

Fluorescence: Broad spectrum

Dyes, antibodies

Fixed preparation

DNA (blue) PtK cell microtubules (green) F-actin (red) labeled

Live cell/organism

C. elegans