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Virus Reference and Surveillance Laboratory (VRSL)

Clinical Virology Program

Links

Contact Information

Lab Director: Robert D. Boromisa, PhD.
Telephone: (518) 474-4177

Publications and Conference Presentations:

Recent Publications

Peer reviewed literature:

  • Khiabanian H, Farrell GM, St. George K, Rabadan R (2009): Differences in Patient Age Distribution between Influenza A Subtypes. PLoS ONE 4(8): e6832
  • Ghedin E, Fitch A, Boyne A, Griesemer S, DePasse J, Bera J, Zhang X, Halpin RA, Smit M, Jennings L, St. George K, Holmes EC, Spiro DJ (2009): Mixed infection and the genesis of influenza diversity. J. Virol. 83: 8832-41
  • Ginocchio C and St. George K (2009): Likelihood that an unsubtypeable influenza A result in the Luminex xTAG Respiratory Virus Panel is indicative of novel A/H1N1 (swine-like) influenza. J. Clin. Microbiol. 47: 2347-8
  • Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish AB, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery S, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD Jr., Boxrud D, Sambol AR, Abid SH, St. George K, et al (2009): Antigenic and Genetic Characteristics of a Novel 2009 A(H1N1) Influenza Virus Circulating in Humans. Science 325: 197-201
  • Laplante J, Marshall S, Shudt M, Reisdorf E, St. George K.(2009): Influenza Antiviral Resistance Testing in New York and Wisconsin, 2006-2008: Methodology and Surveillance Data. Journal of Clinical Microbiol 47:1372-8
  • Dharan NJ, Gubareva LV, Meyer J, Okomo-Adhiambo M, McClinton R, Marshall S, St. George K, Epperson S, Brammer L, Oseltamivir-Resistance Working Group, Klimov AI, Bresee J, Fry AM (2009): Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA. 301:1034-1041.
  • Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, St. George K, Taylor J, Spiro DJ, Sengamalay NA, Ghedin E, Taubenberger JK, Holmes EC. (2008): Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathogens 4(2) e1000012. doi:10.1371 /journal.ppat.1000012.
  • Dare R, Sanghavi S, Bullotta A, Keightley M-C, St. George K, Wadowsky RM, Paterson D, McCurry KR, Reinhart TA, Husain S, Rinaldo CR (2007): Detection of human metapneumovirus (hMPV) infection in immunosuppressed lung transplant recipients and children evaluated for pertussis. Journal of Clinical Microbiology 45: 548-52.
  • Sampath R, Russell KL, Massire C, Eshoo MW, Harpin V, Blyn LB, Melton R, Ivy C, Pennella T, Li F, Levene H, Hall TA, Libby B, Fan N, Walcott DJ, Ranken R, Pear M, Schink A, Drader J, Moore D, Metzgar D, Addington L, Rothman R, Gaydos CA, Yang S, St. George K, Fuschino M, Dean AB, Stallknecht D, Goekjian G, Yingst S, Monteville M, Saad MD, Whitehouse CA, Baldwin C, Rudnick KH, Hofstadler SA, Lemon SM, Ecker DJ (2007): Rapid surveillance of the global spread of emerging influenza virus genotypes by mass spectrometry. PLoS ONE 2(5): e489. doi: 10.1371/journal.pone.0000489.
  • Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St. George K, Briese T, Lipkin WI (2006): MassTag PCR detection of respiratory pathogens, including a new rhinovirus genotype, causing influenza-like illness in New York State, 2004-2005. Journal of Infectious Diseases 194: 1398-1402.
  • Keightley M-C, Bullotta A, Dauber J, Rinaldo C, St. George K (2006): Clinical utility of CMV early and late transcript detection with NASBA in bronchoalveolar lavages. Journal of Clinical Virology 37: 258-264.
  • Nelson MI, Simonsen L, Viboud C, Miller MA, Taylor J, St. George K, Griesemer SB, Ghedin E, Sengamalay NA, Spiro DJ, Volkov I, Grenfell BT, Lipman DJ, Taubenberger JK, Holmes EC (2006): Stochastic processes are key determinants of short-term evolution in influenza A virus. PLoS Pathogens: 2(12): e125. doi:10.1371/juurnal.ppat 0020125.
  • Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, St. George K, Grenfell BT, Salzberg SL, Fraser CM, Lipman DJ, Taubenberger JK (2005): Whole genome analysis of human influenza A virus reveals multiple persistent lineages and reasssortment events among recent H3N2 viruses. PLoS Biology Vol. 3, No. 9, e300.
  • Ghedin E, Miller NA, Shumway M, Zaborsky J, Feldblyum T, Subbu V, Spiro D, Sitz J, Koo H, Bolotov P, Dernovoy D, Tatusova T, Bao Y, St. George K, Taylor J, Lipman DJ, Fraser CM, Taubenberger JK, and Salzberg SL (2005): Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature, advance online publication, 5 October 2005 (doi: 10.1038/nature04239), 437:1162-1166.
  • Keightley M-C, Sillekens P, Schippers W, Rinaldo C, St. George K (2005): Real-time NASBA detection of SARS-associated coronavirus and comparison with real-time reverse transcription PCR. J Med Virol 77: 602-608.

Book chapters:

  • Clarke L and St. George K (2007): Viruses and chlamydiae. In: Clinical Microbiology Procedures Handbook, 3rd edition, Garcia L (ed) ASM Press, Washington DC.
  • St. George K, Hoji A and Rinaldo CR Jr. (2006): Cytomegalovirus. In B. Detrick, R.G. Hamilton and J. D. Folds (eds.). Manual of Molecular and Clinical Laboratory Immunology, 7th edition. American Society for Microbiology, Washington, D.C., p. 648-657, 2006.

Conference Presentations

Invited presentations:

  • Ostrowski S, Paz Carlos M, Zimmerman S, Oleszko W, Abid S, St. George K (2008): New York State Laboratory Response Network Laboratory Influenza Surge Drill. (Abstract #216) Public Health Preparedness Summit 2008, February 19-22, Atlanta, Georgia.
  • St. George K (2007): Highly virulent adenovirus 14: case study and outbreaks. General Bacteriology & Virology Symposium, September 27, Albany NY.
  • St. George K (2006): Laboratory Preparedness for Pandemic Influenza in New York State. 15th International Conference "AIDS, Cancer and Public Health". May 23, St. Petersburg, Russia.
  • St. George K (2006): Avian influenza. The University Symposia in Clinical Laboratory Science "Strange Encounters of the Microbe Kind - The Weird Bugs". October 25, University of Medicine and Dentistry, Scotch Plains, New Jersey.
  • St. George K (2006): Influenza diagnostics in the context of pandemic preparedness. 41st Annual Regional Meeting Eastern New York, Connecticut Valley, New York City, and Northeast Branches of the American Society for Microbiology, November 1 and 2, Albany, New York.
  • St.George K (2006): Pandemic Flu - Laboratory Issues. New York State Department of Health Speed Rounds. Feb. 9, Albany, NY.
  • St. George K (2006): Pandemic influenza: NYS laboratory response. NBC Public Health / Biodefense Advisory Council Meeting. March 9, New York, NY.
  • St. George K (2006): Influenza diagnosis and the NYS laboratory response plan for a pandemic. New York State Legislative Workshop. April 25, Albany, NY.
  • St. George K (2005): The laboratory diagnosis of avian influenza. 40th Annual Meeting of the Academy of Clinical Laboratory Physicians and Scientists, Pittsburgh, PA.
  • St. George K (2005): Pandemic influenza preparedness: issues, challenges and logistics. Northeast Public Health Laboratory Preparedness Conference. Albany, NY.
  • Taylor, J. (2005) "Avian Influenza: Laboratory Issues. "Avian Influenza: Preparation and Response Workshop, Center for Public Health Preparedness, School of Public Health, University at Albany, Albany, NY June 22, 2005
  • Taylor, J. (2005) "Meeting PT Requirements in the Clinical Virology Laboratory". APHL Infectious Disease Meeting, Orlando, FL May 2-4, 2005

Proffered papers:

  • Dupuis M, Hull R, Wang H, Nattanmai S, Curran M, Lamson D, Dzigua L, Glasheen B, Fusco H, St. George K, Tavakoli N.(2008): Evolution of the New York State viral encephalitis molecular detection program. 24th Annual Clinical Virology Symposium, Apr 25-30, Daytona Beach, Florida.
  • Mingle L, Rush-Wilson K, St. George K (2008): Adenovirus detected in autopsies: New York State 2007. 24th Annual Clinical Virology Symposium, Apr 25-30, Daytona Beach, Florida.
  • Laplante J, Marshall SA, Van T, Reisdorf ES, Shudt M, Warshauer DM, Shult PA, St. George K. (2008): Surveillance of antiviral resistant influenza from 2006-2008 by a network of U.S. state public health laboratories. 24th Annual Clinical Virology Symposium, Apr 25-30, Daytona Beach, Florida.
  • Lamson DM, Dean AB, Han J, St. George K (2007): Clinical Validation of a Multiplex PCR for the Detection of 11 Respiratory Viruses in Respiratory Swabs. 23rd Annual Clinical Virology Symposium, Apr 29-May 2, Clearwater Beach, Florida.
  • Griesemer SB, Ghedin G, Holmes EC, Spiro DJ, Sengamalay NA, St.George K (2007): Investigation of Host-Mediated Mutations in H3N2 Influenza Viruses in Embryonated Eggs, MDCK And pRhMK Cells. 23rd Annual Clinical Virology Symposium, Apr 29-May 2, Clearwater Beach, Florida.
  • Lamson DM, Dean AB­, St. George K (2007): Clinical validation of a molecular method for the simultaneous detection of 11 respiratory viruses causing influenza-like illness. Options for the Control of Influenza VI, June 17-23, Toronto, Canada.
  • Zhou B, Donnelly ME, Hinckley RA, Gerzak GV, St. George K, Wentworth DE (2007): Plasmid-based rescue of influenza A virus directly from swab specimens. American Society for Virology 26th Annual Meeting, July 14-18, Oregon State University (Abstract Number: 497, P30-17)
  • Schaffzin JK, Hoefer D, Hoyt L, Lurie M, Johnson G, Sackett D, Keithly J, Rosen B, Tavakoli N, St. George K, Wallace B (2006): A Large Outbreak of Cryptosporidiosis Associated with a Recreational Water Feature - New York, 2005. 55th Annual Epidemic Intelligence Service (EIS) Conference, April 24-28, 2006, Atlanta, GE
  • Lamson DM, Kapoor V, Briese T, Palacios G, Liu Z, Dean AB­, St. George K, Lipkin WI (2006): Detection of Alternative Etiological Agents by Multiplex Mass Tag PCR in patients presenting with Influenza-like Illness. 22nd Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Sanghavi S, Keightley MC, Kwak E, Bullotta A, Lewandowski K, Boes SS, Lassak M, St. George K, Rinaldo C (2006): Assessing Cytomegalovirus Load In Blood By Real Time PCR Targeting US17 And UL54 Regions Of The Viral Genome. 22nd Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Karchava M, Fuschino M, Kinne J, Rush-Wilson K, St. George K (2006): Comparison Of R-Mix, R-Mix Too And Rhesus Monkey Kidney Cells For Detection Of Influenza Virus And Production Of Progeny Virus. 22nd Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Battaglioli G, Clement N, Linden RM, St. George K (2006): High Prevalence Of Human Bocavirus In Pediatric Autopsy Respiratory Specimens. 22nd Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Dare R, Keightley MC, St.George K, Husain S and Rinaldo C (2005): Detection Of Human Metapneumovirus By Quantitative Real Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) And Real Time Nucleic Acid Sequence Based Amplification (NASBA). 21st Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Griesemer SB, Tavakoli N, Taylor J and St.George K (2005): Detection of Human Metapneumovirus in a Fatal Pediatric Pneumonia. 21st Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Dean AB, Lamson DM, Han J, Cronin K, Varnavas L, Spargo W, Griesemer S, Nattanmai SM, Fuschino ME, Tavakoli N, St.George K and Taylor J (2005): Evaluation Of Genaco's Molecular Differential Diagnostic Technology For The Detection Of RNA Respiratory Viruses. 21st Annual Clinical Virology Symposium, Clearwater Beach, Florida.
  • Lamson DM, Kapoor V, Briese T, Palacios G, Liu Z, Dean AB­, St. George K and Lipkin WI (2005): Detection of Alternative Etiological Agents by Multiplex Mass Tag PCR in patients presenting with Influenza-like Illness. Northeast Biodefense Center Conference, Cold Spring Harbor, New York, Sep 11-13, 2005.