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Impact of Pervasive Transcription in Bacteria

Description:

Postdoctoral positions are available to study the role of regulatory RNAs in bacteria. We have recently identified over 1,000 novel RNAs overlapping protein-coding genes in the model bacterium, /Escherichia coli/. Our goal is tounderstand the impact of this new class of RNA on gene expression in /E. coli/ and related bacterial species. This work is funded by an NIH New Innovator Award.

Relevant publications:

Dornenburg, J., DeVita, A. M., Palumbo, M. J. and Wade, J. T. (2010). Widespread antisense transcription in Escherichia coli. mBio, 1, e00024-10.

Reppas, N. B., Wade, J. T., Church, G. M. and Struhl, K. (2006). The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate-limiting. Mol. Cell, 24, 747-757.

Wade, J. T., Castro, D. R., Grainger, D. C., Hurd, D., Busby, S. J., Struhl, K.* and Nudler, E. (2006). Extensive functional overlap between Sigma factors in Escherichia coli. Nat. Struct. Mol. Biol., 13, 806-814.