2005 Public Lecture Series
Genetics and Age: Escaping Alzheimers and Parkinsons
Genes and the environment contribute to most complex diseases to varying degrees, yet historically the two were studied in isolation. Genetic epidemiology aims to determine if there is a genetic basis to disease, and if so what is the relative size of its effect under different enviromental conditions. Such efforts might lead to mechanisms to delay age of onset of age-related neurodegenerative disorders, for example. Identifying the causes of of Parkinson's and Alzheimer's diseases, and the factors that modulate their expression, is the first step. Understanding why some people develop neurdegenerative disease in their 30s and 40s while others are spared into their 90s may yield knowledge needed to delay the onset. A multi-institutional Global Genetic Consortium led by Wadsworth is studying the interactive effects of genes and protective environmental factors on disease susceptibility, onset age, prognosis and response to treatment for Parkinson's. The results may lead to clinical trials for prevention and treatment, using simple lifestyle modifications, but individually tailored based on genetic makeup for optimal effectiveness.
Related links:
Parkinson's Disease
Alzheimer's
Association
Michael J. Fox
Foundation for Parkinson's Research
Dr. Payami is a research scientist at Wadsworth Center and a professor of molecular genetics at the School of Public Health, University at Albany. She received a doctorate in 1985 from the University of California at Berkeley, where she studied the genetics of complex diseases. Her postdoctoral work, also at Berkeley, focused on how best to integrate genetics with epidemiology in order to study disorders that involve both genetic and environmental factors. She has employed this approach for the last 18 years to study Alzheimer's disease, Parkinson's disease and healthy aging. Her ultimate goal is to delay disease onset beyond the normal life span; conversely, to promote healthy brain aging. Her research is supported by grants from the National Institutes of Health and the Michael J. Fox Foundation.