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Investigators and Program Directors

Joan Curcio

Joan Curcio

Research Scientist, Wadsworth Center, Molecular Genetics
Associate Professor and Chair, Biomedical Sciences,
School of Public Health Ph.D., George Washington University (1987)
Postdoctoral Fellow, National Cancer Institute-Frederick Cancer Research Center

E-mail: joan.curcio@wadsworth.org

<< Research Interests

Select Publications

  • Baller, J., Gao, J., Stamenova, R., Curcio, M.J. and Voytas, D.F. 2012. A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon. Genome Res. 22(4): 704-13.
    Belfort, M., Curcio, M.J. and Lue, N.F. 2011. Telomerase and retrotransposons: Reverse transcriptases that shaped genomes. Proc. Natl. Acad. Sci. USA. 108: 20304-10.
  • Maxwell, P.H., Burhans, W.C. and Curcio, M.J. 2011. Retrotransposition is associated with genome instability during chronological aging. Proc. Natl. Acad. Sci. USA. 108: 20376-81.
    Chalamcharla, V., M.J. Curcio and M. Belfort. 2010. Nuclear expression of a group II intron is consistent with spliceosomal ancestry. Genes Dev. 24:827-36.
  • Dutko J.A., A.E. Kenny, E.R. Gamache and M.J. Curcio. 2010. 5' to 3' mRNA decay factors colocalize with Ty1 Gag and human APOBEC3G and promote Ty1 retrotransposition. J. Virol. 84: 5052-66.
  • Stamenova, R., P. Maxwell, A.E. Kenny, M.J. Curcio. 2009. Rrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotransposition. Genetics 182: 711-723.
  • Beauregard, A., M.J. Curcio and M. Belfort. 2008. The take and give between retrotransposable elements and their hosts. Ann. Rev. Genet. 42: 587-617.
  • Maxwell, P.H. and M.J. Curcio. 2008. Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase mutants. Genetics 179: 2313-7.
    Maxwell, P.H. and M.J. Curcio. 2007. Retrosequence formation restructures the yeast genome. Genes Dev. 21:3308-18.
  • Curcio, M.J., Kenny, A.E., Moore, S., Garfinkel, D.J., Weintraub, M., Gamache, E.R., Scholes, D.T. 2007. S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon, Ty1. Mol. Cell. Biol. 27: 8874-85.
  • Maxwell, P.H. and M.J. Curcio. 2007. Host factors that control LTR-retrotransposons in Saccharomyces cerevisiae: implications for the regulation of mammalian retroviruses. Eukaryotic Cell. 6: 1069-1080.
  • Curcio, M.J. and Belfort, M. 2007. The beginning of the end: links between ancient retroelements and modern telomerases. Proc. Natl. Acad. Sci. USA. 100: 15736-15741.
  • Mou, Z., A.E. Kenny and M. J. Curcio. 2006. Hos2 and Set3 promote integration of Ty1 retrotransposons at tRNA genes in Saccharomyces cerevisiae. Genetics. 172: 2157-2167.
  • Dutko, J. A., A. Schafer, A.E. Kenny, B.R. Cullen and M.J. Curcio. 2005. Inhibition of a yeast LTR-retrotransposon by human APOBEC3 cytidine deaminases. Curr. Biol. 15: 661-666.
  • Maxwell, P.H., C. Coombes, A.E. Kenny, J.L. Lawler, J.D. Boeke and M.J. Curcio. 2004. Ty1 mobilizes subtelomeric Y’ elements in telomerase-negative Saccharomyces cerevisiae survivors. Mol. Cell. Biol. 24: 9887-9898.
  • Scholes, D.T., A.E. Kenny, E.R. Gamache, Z. Mou and M.J. Curcio. 2003. Activation of an LTR-retrotransposon in response to telomere erosion. Proc. Natl. Acad. Sci. USA 100: 15736-15741.
    Curcio, M.J. and K. M. Derbyshire. 2003. The outs and ins of transposition: From Mu to Kangaroo. Nat. Rev. Mol. Cell Biol. 4: 821-902.

Contact Information

E-mail: joan.curcio@wadsworth.org
Phone: (518) 473-4213
Fax: (518) 474-3181