Investigators and Program Directors

Select Publications

• Bitter, W., Houben, E.N.G., Bottai, D., Brodin, P., Brown, E.J., Cox, J.S., Derbyshire, K., Fortune, S.M., Gao, L-Y., Kiu, J., Gey van Pittius, N.C., Pym, A.S., Rubin, E.J., Sherman, D.R., Cole, S.T., and Brosch, R. (2009) "Systematic genetic nomenclature for type VII secretion systems." Plos Pathogens In press.
• Nguyen, K.T., Piastro, K., and Derbyshire, K.M. (2009) "LpqM, a mycobacterial lipoprotein-metalloproteinase, is required for conjugal DNA transfer in Mycobacterium smegmatis." J. Bacteriol. 191, 2721-2727.
• Coros, A., Callahan, B.P., Battaglioli, E, and Derbyshire, K.M. (2008) "The Specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis." Mol. Microbiol. 69, 794-808. PMC2347380
• Coros, A., De Conno, E., and Derbyshire, K.M. (2008) "IS6110, a Mycobacterium tuberculosis complex-specific insertion sequence, is also present in the genome of Mycobacterium smegmatis, suggestive of lateral gene transfer among mycobacterial species." J Bacteriol 190, 3408-3410. PMC2044538
• Mo, Y., Quanquin, N.M., Vecino, W.H., Ranganathan, U.M., Tesfa, L., Bourn, W., Derbyshire, K. M., Letvin, N.L., Jacobs, W.R., Fennelly, G.J. (2007) "Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization." Infection & Immunity, 75, 4804-4816. PMC2044538
• Wardle, S.J., O'Carroll, M., Derbyshire, K.M. and Haniford, D.B. (2005) "The Global Regulator H-NS Acts Directly on the Transpososome To Promote Tn10 Transposition." Genes & Development, 19, 2224-2235.
• Wang, J., Karnati, P., Takacs, C.M., Kowalski, J., and Derbyshire, K.M. (2005) "Chromosomal DNA transfer in Mycobacterium smegmatis is mechanistically different from classical Hfr chromosomal DNA transfer." Mol. Microbiol. 58, 280-288.
• Twiss, E., Coros, A.M., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress." Mol. Microbiol. 57, 1593-1607.
• Coros, A.M., Twiss, E., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Genetic evidence that GTP is required for transposition of IS903 and Tn552 in Escherichia coli" J. Bacteriol., 187, 4598-4606.
• Flint, J., Kowalski, J., Karnati, P. and Derbyshire, K.M. (2004) "The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis" Proc. Natl. Acad. Sci. U.S.A. 101, 12598-12603 PMC51503.
• Wang, J. and Derbyshire, K.M. (2004) "Plasmid DNA transfer in Mycobacterium smegmatis involves novel DNA rearrangements in the recipient, which can be exploited for molecular genetic studies" Mol. Microbiol. 53, 1233-1241.
• Swingle, B., O'Carroll, M., Haniford, D. and Derbyshire, K.M. (2004) "The effect of host-encoded nucleoid proteins on transposition: H-NS influences targeting of both IS903 and Tn10." Mol. Microbiol. 52, 1055-1068.
• Curcio, M.J. and Derbyshire, K.M. (2003) "The outs and ins of transposition from Mu to kangaroo". Nature reviews, Molecular Cell Biology 4;865-877.
• Wang, J., Parsons, L.M., and Derbyshire, K.M. (2003) "Unconventional conjugal DNA transfer in mycobacteria". Nat Genet 34: 80-84.

Contact Information

Phone 518-473-6079
Fax 518-486-7971
E-mail: keith.derbyshire@wadsworth.org