Investigators and Program Directors

Select Publications

• Coros, A.M., Twiss, E., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Genetic evidence that GTP is required for transposition of IS903 and Tn552 in Escherichia coli" J. Bacteriol., 187, 4598-4606.
• Derbyshire, K.M., and Grindley, N.D.F. (2005) "DNA Transposons: different proteins and mechanisms, but similar rearrangements." In The Bacterial Chromosome. P. Higgins (ed) Washington, D.C: American Society for Microbiology, pp467-497.
• Twiss, E., Coros, A.M., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress." Mol. Microbiol. 57, 1593-1607.
• Wang, J., Karnati, P.K., Takacs, C.M., Kowalski, J.K., and Derbyshire, K.M. (2005) "Chromosomal DNA transfer in Mycobacterium smegmatis is mechanistically different from classical Hfr chromosomal DNA transfer." Mol. Microbiol. 58, 280-288.
• Wardle, S.J., O'Carroll, M., Derbyshire, K.M. and Haniford, D.B. (2005) "The Global Regulator H-NS Acts Directly on the Transpososome To Promote Tn10 Transposition." Genes & Development, 19, 2224-2235.
• Flint, J., Kowalski, J., Karnati, P. and Derbyshire, K.M. (2004) "The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis" Proc. Natl. Acad. Sci. U.S.A. 101, 12598-12603.
• Swingle, B., O'Carroll, M., Haniford, D. and Derbyshire, K.M. (2004) "The effect of host-encoded nucleoid proteins on transposition: H-NS influences targeting of both IS903 and Tn10." Mol. Microbiol. 52, 1055-1068.
• Wang, J. and Derbyshire, K.M. (2004) "Plasmid DNA transfer in Mycobacterium smegmatis involves novel DNA rearrangements in the recipient, which can be exploited for molecular genetic studies" Mol. Microbiol. 53, 1233-1241.
• Curcio, M.J. and Derbyshire, K.M. (2003) "The outs and ins of transposition from Mu to kangaroo". nature reviews, molecular cell biology 3, issue 11 (November).
• **Wang, J., Parsons, L.M., and Derbyshire, K.M. (2003) "Unconventional conjugal DNA transfer in mycobacteria". Nat Genet 34: 80-84.
• **Editorial discussing this work. Bhatt, A., and Jacobs, W.R., Jr. (2003) Conjugal rites of mycobacteria. Nature Genetics 34: 3-4.
• Kirby, K., Waring, A., Griffin, T.J., Falkinham, J.O., Grindley, N.D.F., and Derbyshire, K.M. (2002) "Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue". Molecular Microbiology 43, 173-186.
• Derbyshire, K.M. (2001) "Cis-acting proteins" In Encyclopedia of Genetics Brenner, S. & Miller, J. (eds.) New York, Academic Press.
• Hu, W-Y., Thompson, W., Lawrence, C.E., and Derbyshire K.M., 2001. Anatomy of a preferred target site for the bacterial insertion sequence IS903. J. Mol Biol. 306:403-416.
• Tavakoli, N.P. and Derbyshire K.M. (2001) "Tipping the balance between replicative and conservative transposition" EMBO J. 11, 2923-2930.
• Derbyshire, K. M., and Bardarov, S. 2000. DNA transfer in Mycobacteria, pp93-107. In W. R. Jacobs and G. F. Hatfull, (eds.) Molecular Genetics of Mycobacteria. ASM Press, Washington, D.C.
• Machowski, E. E., McAdam, R. A., Derbyshire, K. M. and Mizrahi, V. 2000. Construction and application of mycobacterial reporter transposons Gene. 253:67-75.
• Griffin, T.J., Parsons, L. M., Leschziner, A. E., DeVost, J., Derbyshire, K. M. and Grindley, N.D.F. 1999. "In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis." Nucleic Acids Research. 27:3859-3865.
• Tavakoli, N. P. and Derbyshire K. M. 1999. "IS903 transposase mutants that suppress defective inverted repeats". Molecular Microbiology. 31:1183-1196.
• Thomson, V. J., Bhattacharjee, M., Fine, D. H., Derbyshire, K. M. (corresponding author), and Figurski, D. H. 1999. Direct selection of IS903 transposon insertions using a broad-host-range vector: Isolation of catalase-deficient mutants of Actinobacillus actinomycetemcomitans. J. Bacteriol. 181:7298-7307.
• Hu, W-Y. and Derbyshire K. M. 1998. Target choice and orientation preference of the insertion sequence IS903. J. Bacteriol. 180:3039-3048.
• Parsons, L. M., Jankowski, C, and Derbyshire, K. M. 1998. Conjugal transfer of chromosomal DNA in Mycobacterium smegmatis. Molecular Microbiology. 28:571-582.

Contact Information

Phone 518-473-6079
Fax 518-486-7971
E-mail: keith.derbyshire@wadsworth.org