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Investigators and Program Directors

Keith M. Derbyshire

Keith M. Derbyshire

Research Scientist, Wadsworth Center,
Molecular Genetics

Professor, School of Public Health, Biomedical Sciences

Ph.D., Edinburgh University (1983)
Postdoctoral training, Yale University

E-mail: keith.derbyshire@wadsworth.org

<< Research Interests

Select Publications

  • Bitter, W., Houben, E.N.G., Bottai, D., Brodin, P., Brown, E.J., Cox, J.S., Derbyshire, K., Fortune, S.M., Gao, L-Y., Kiu, J., Gey van Pittius, N.C., Pym, A.S., Rubin, E.J., Sherman, D.R., Cole, S.T., and Brosch, R. (2009) "Systematic genetic nomenclature for type VII secretion systems." Plos Pathogens In press.
  • Nguyen, K.T., Piastro, K., and Derbyshire, K.M. (2009) "LpqM, a mycobacterial lipoprotein-metalloproteinase, is required for conjugal DNA transfer in Mycobacterium smegmatis." J. Bacteriol. 191, 2721-2727.
  • Coros, A., Callahan, B.P., Battaglioli, E, and Derbyshire, K.M. (2008) "The Specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis." Mol. Microbiol. 69, 794-808. PMC2347380
  • Coros, A., De Conno, E., and Derbyshire, K.M. (2008) "IS6110, a Mycobacterium tuberculosis complex-specific insertion sequence, is also present in the genome of Mycobacterium smegmatis, suggestive of lateral gene transfer among mycobacterial species." J Bacteriol 190, 3408-3410. PMC2044538
  • Mo, Y., Quanquin, N.M., Vecino, W.H., Ranganathan, U.M., Tesfa, L., Bourn, W., Derbyshire, K. M., Letvin, N.L., Jacobs, W.R., Fennelly, G.J. (2007) "Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization." Infection & Immunity, 75, 4804-4816. PMC2044538
  • Wardle, S.J., O'Carroll, M., Derbyshire, K.M. and Haniford, D.B. (2005) "The Global Regulator H-NS Acts Directly on the Transpososome To Promote Tn10 Transposition." Genes & Development, 19, 2224-2235.
  • Wang, J., Karnati, P., Takacs, C.M., Kowalski, J., and Derbyshire, K.M. (2005) "Chromosomal DNA transfer in Mycobacterium smegmatis is mechanistically different from classical Hfr chromosomal DNA transfer." Mol. Microbiol. 58, 280-288.
  • Twiss, E., Coros, A.M., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress." Mol. Microbiol. 57, 1593-1607.
  • Coros, A.M., Twiss, E., Tavakoli, N.P., and Derbyshire, K.M. (2005) "Genetic evidence that GTP is required for transposition of IS903 and Tn552 in Escherichia coli" J. Bacteriol., 187, 4598-4606.
  • Flint, J., Kowalski, J., Karnati, P. and Derbyshire, K.M. (2004) "The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis" Proc. Natl. Acad. Sci. U.S.A. 101, 12598-12603 PMC51503.
  • Wang, J. and Derbyshire, K.M. (2004) "Plasmid DNA transfer in Mycobacterium smegmatis involves novel DNA rearrangements in the recipient, which can be exploited for molecular genetic studies" Mol. Microbiol. 53, 1233-1241.
  • Swingle, B., O'Carroll, M., Haniford, D. and Derbyshire, K.M. (2004) "The effect of host-encoded nucleoid proteins on transposition: H-NS influences targeting of both IS903 and Tn10." Mol. Microbiol. 52, 1055-1068.
  • Curcio, M.J. and Derbyshire, K.M. (2003) "The outs and ins of transposition from Mu to kangaroo". Nature reviews, Molecular Cell Biology 4;865-877.
  • Wang, J., Parsons, L.M., and Derbyshire, K.M. (2003) "Unconventional conjugal DNA transfer in mycobacteria". Nat Genet 34: 80-84.

Contact Information

Phone 518-473-6079
Fax 518-486-7971
E-mail: keith.derbyshire@wadsworth.org