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Investigators and Program Directors

James Dias

James A. Dias

Research Scientist, Wadsworth Center, Immunology
Associate Professor and Chair, School of Public Health, Biomedical Sciences

Ph.D., Washington State University (1979)
Postdoctoral training, Albany Medical College

E-mail: dias@wadsworth.org

<< Research Interests

Select Publications

  • Ulloa-Aguirre, A., Dias, J.A. and Bousfield, G.R. (2009) Gonadotropins and the importance of glycosylation. In: Post-translational Modification of Protein Biopharmaceuticals. Ed. Gary Walsh Wiley-VCH Verlag GmbH and Co. Weinheim. ISBN 978-527-32074-05.
  • Janovick,J.J., Maya-Nunez,G., Ulloa-Aguirre,A.,Ji.T.,Huhtaniemi,I.T., Dias,JA., Verbost,P., Conn,P.M. (2009) Increased plasma membrane expression of hFSHR by a small molecule thienopyrimidine. Mol Cell Endocrinol. 298(1-2):84-8
  • Uribe, A., Zariñán, T., Pérez-Solis, M.A., Gutiérrrez-Sagal, R., Jardón-Valadez, E., Piñeiro, A., Dias, J.A. and Ulloa-Aguirre, A. (2008) Functional and structural roles of conserved cysteine residues in the carboxyl-terminal domain of the human follicle-stimulating hormone receptor. Biol Reprod. May;78 (5 ):869-82 .
  • Thomas,RM, Nechamen CA, Mazurkiewicz, JM, Muda, M, Palmer, S. And Dias, JA. (2007) FSH Receptor Forms Oligomers and Shows Evidence of C-terminal Proteolytic Processing Endocrinology 148 (5 ):1987-95 .
  • Nechamen CA, Thomas RM, Dias JA. (2007) APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol. 2;260-262:93-9.
  • Ulloa-Aguirre A, Uribe A, Zarinan T, Bustos-Jaimes I, Perez-Solis MA, Dias JA. (2007) Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expression. Mol Cell Endocrinol. 260-262:153-62.
  • Ulloa-Aguirre,A., Zarinan, T., Ma, A., Casas, P. And Dias, J.A. (2007) The mutiple facts of follicle-stimulating hormone receptor function. Endocrine 32 (3 ):251-63 .
  • Thomas,RM, Nechamen CA, Mazurkiewicz, JM, Muda, M, Palmer, S. And Dias, JA. FSH Receptor Forms Oligomers and Shows Evidence of C-terminal Proteolytic Processing. Endocrinology 148(5):1987-95, 2007.
  • Nechamen CA, Thomas RM, Dias JA APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol. 2007 Jan 2;260-262:93-9. Epub 2006 Oct 9. PubMed.
  • Ulloa-Aguirre A, Uribe A, Zarinan T, Bustos-Jaimes I, Perez-Solis MA, Dias JA Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expression. Mol Cell Endocrinol. 2007 Jan 2;260-262:153-62. Epub 2006 Oct 12. PubMed.
  • Dias, J.A., Nechamen, C.A. and Atari, R. Identifying protein interactors in gonadotropin action. Endocrine. 26(3): 241-247, 2005.
  • Krystek, S.R. and Dias, J.A. Glycoprotein hormones tied but not tethered like other cysteine-knot cytokines. Trends. Pharmacol. Sci. 26(9):439-442, 2005.
  • Dias, J. A. (2005) Fertility hormone in repose. Nature 433, 203-204.
  • Cohen,B.D., C.A. Nechamen, and J.A. Dias (2004) Human follitropin receptor interacts with the adapter protein 14-3-3 tau. Mol. Cell. Endocrin. 31;220(1-2):1-7.
  • Nechamen, C.A., R.M. Thomas, B.D. Cohen, G. Acevedo, P.I. Poulikakos, J.R. Testa, and J.A. Dias (2004) Human follicle stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: Potential involvement of the PI3K pathway in FSH signaling. Biol. Reprod., 71(2):629-36.
  • Nechamen, C. A. and Dias, J. A. . Point mutations in follitropin receptor result in ER retention. Molec.Cell.Endocrinol. 201:123-131,2003.
  • Fox, K., Dias, J.A. and Van Roey, P. Three dimensional structure of human Follitropin. Molecular Endocrinology, 15:378-389, 2001.

Contact Information

E-mail: dias@wadsworth.org