Investigators and Program Directors

Select Publications

• Zhou, X., Zhang, X., Weng, Y., Fang, C., Kaminsky, L., and Ding, X.: High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice. J. Steroid Biochem. Mol. Biol. In press.
• D’Agostino, J., Zhuo, X., Shadid, M., Morgan, D. G., Zhang, X., Shu, Y.-Z., Humphreys, W. G., Yost, G. S., and Ding, X.: The pneumotoxin 3-methylindole is a substrate as well as a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract. Drug Metab. Dispos. In press.
• Wu, H., Zhang, X., Ling, G., D’Agostino, J., and Ding, X.: mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple cis-regulatory single nucleotide polymorphisms. Pharmacogenetics Genomics. In press.
• Sneitz, N., Court, M. H., Zhang, X., Laajanen, K., Yee, K., Dalton, P., Ding, X., and Finel M.: Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. Pharmacogenetics Genomics. In press.
• Sim, S. C., Miller, W. L., Zhong, X., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Fluck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W., and Ingelman-Sundberg, M.: Nomenclature for alleles of the cytochrome P450 oxidoreductase gene. Pharmacogenetics Genomics 19, 565–566
• Zhang, Q.-Y., Fang, C., Dunbar, D., Zhang, J., Kaminsky, L.S., and Ding, X. An intestinal epithelium-specific cytochrome P450 reductase-knockout mouse model: direct evidence for a role of intestinal cytochromes P450 in first-pass clearance of oral nifedipine. Drug Metab. Dispos. 37, 651–657, 2009. NIHMSID #82117
• Zhang, Q.-Y. and Ding, X. The CYP2F, CYP2G and CYP2J Subfamilies. In Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics. (Ioannides C, Ed), Chapter 10, RSC Publishing, Cambridge, UK, pp. 309-353, 2008.
• Brusick, D., Small, M. S., Cavalieri, E. L., Chakravarti, D., Ding, X., Longfellow, D. G., Nakamura, G., Rogan, E. C., Swenberg, J. A.: Possible genotoxic modes of action for naphthalene. Regul. Toxicol. Pharmacol. 51, S43–S50, 2008.
• D’Agostino, J., Zhang, X., Wu, H., Ling, G., Zhang, Q-Y., and Ding, X.: Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidence of lung adenocarcinoma in smokers. Drug Metab. Dispos. 36, 2316–2323, 2008. NIHMSID #60659
• Fang, C., Gu, J., Xie, F., Behr, M., Yang, W., Abel, E. D., and Ding, X.: Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated cardiac toxicity. Drug Metab. Dispos., 36, 1722-1828, 2008. NIHMSID #49730
• Dostalek, M., Hardy, K. D., Milne, G. L., Morrow, J. D., Chen, C., Gonzalez, F. J., Gu, J., Ding, X., Martin, M. V., and Guengerich, F. P.: Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J. Biol. Chem., 283, 17147–17157, 2008.
• Fang, C., Behr, M., Xie, F., Lu, S., Doret, M., Luo, H., Yang, W., Aldous, K., Ding, X., and Gu, J.: Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism. Toxicol. Appl. Pharmacol. 227, 48–55, 2008.
• Zhang, X., D’Agostino, J., Wu, H., Zhang, Q-Y., von Weymarn, L., Murphy, S. E., and Ding, X.: CYP2A13: Variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. J. Pharmacol. Expt. Ther. 323, 570-578, 2007.
• Zhang, Q-Y., Kaminsky, L. S., Dunbar, D., and Ding, X.: Role of small intestinal cytochrome P450 in the bioavailability of oral nifedipine. Drug Metab. Dispos. 35, 1617–1623, 2007.
• Weng, Y., Fang, C., Turesky, R. J., Behr, B., Kaminsky, L. S., and Ding, X.: Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Res. 67, 7825-7832, 2007.
• Gu, J., Chen, C-S., Wei, Y., Fang, C., Xie, F., Kannan, K., Yang, W., Waxman, D. J., and Ding, X.: A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. J. Pharmacol. Expt. Ther. 321, 9-17, 2007.
• Ling, G., Wei, Y., and Ding, X.: Transcriptional regulation of human CYP2A13 expression in the respiratory tract by C/EBP and epigenetic modulation. Mol. Pharmacol. 71, 807-816, 2007.

Contact Information

Phone: (518) 486-2585
Fax: (518)-473-8722
E-mail: dingx@wadsworth.org