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Investigators and Program Directors

Jun Gu

Jun Gu

Research Scientist, Wadsworth Center, Molecular Toxicology
Assistant Professor, School of Public Health, Environmental Health Sciences

Ph.D., Pharmacology, Shanghai Medical College, Fudan University (1993)
Postdoctoral training: Wadsworth Center, NYS Dept of Health; University of Toronto


Research Interests

The overall goal of our research is to study the mechanisms of environmental diseases using molecular approaches. We are particularly interested in diseases of the kidney and the central nervous system. Our current research activities are focused on the development and application of conditional knockout mouse models that target the NADPH-cytochrome P450 reductase (CPR). CPR is essential for the functions of all microsomal cytochrome P450 monooxygenases. CPR is also involved in the production of reactive oxygen species. We are testing the hypothesis that CPR, through its activities in reactive oxygen species production, contributes to the pathogenesis of Alzheimer's disease. These studies may lead to a better understanding of the roles of environmental factors in Alzheimer's disease. We are also studying the function of CPR and cytochrome P450 enzymes in the kidney. The kidney, which contains a variety of drug-metabolizing enzymes and xenobiotic transporters, is a primary target for numerous toxicants, including drugs and environmental chemicals. We hope to better understand the molecular mechanisms of chemical-induced renal toxicity, in order to provide more effective methods for the prevention and clinical therapy of renal injuries induced by xenobiotics.

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Contact Information

Phone: 518-473-0782
Fax: 518-486-1505

Key words: drug-metabolizing enzyme, chemical toxicity, neurodegenerative disease, kidney