Investigators and Program Directors

Select Publications

• Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman D, and Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide metabolic activation. J Pharmacol Exp Ther 2007 (in press).
• Gu J, Cui H, Behr M, Zhang QY, Weng Y , Yang W, Zhang L, and Ding X. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol Pharmacol 2005; 67:623-630.
• Wu L, Gu J, Zhang QY, Cui H, Behr M, Kluetzman K, and Ding X. Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450. J Pharmacol Exp Ther 2005; 312: 35-43.
• Zhang QY, Gu J, Su T, Cui H, Zhang X, D'Agostino J, Zhuo X, Yang W, Swiatek P, Ding X. Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochem Biophys Res Commun 2005; 336:1-7.
• Zhuo X, Gu J, Behr M, Swiatek P., Cui H, Zhang QY, Xie Y, Collins D, and Ding X. Target deletion of the olfactory mucosa-specific CYP2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland and effects on CYP2A5 expression in the liver and kidney. J Pharmacol Exp Ther 2004; 308: 719-728.
• Ling G, Gu J, Genter M, Zhuo X, Ding X. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-Biological Interactions 2004; 147: 247-258.
• Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, and Ding X. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function of regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 2003; 278:25895-25901.
• Wu L, Gu J, Weng Y, Kluetzman K, Swiatek P, Behr M, Zhang QY, Zhuo X, Xie Q, and Ding X. Conditional knockout of the mouse NADPH-cytochrome P450 reductase gene. Genesis 2003; 36:177-181.
• Nian M, Gu J, Irwin D, and Drucker DJ. Human glucagons gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression. Am J Physiol Regul Integr Comp Physiol 2002; 282:R173-R183.
• Gu J, Su T, Chen Y, Zhang QY, and Ding X. Expression of biotransformation enzymes in human fetal nasal mucosa: potential roles in developmental toxicity. Toxicol Appl Pharmacol 2000; 165:158-162.
• Gu J, Dudley C, Zhang QY, Spink D, Moss R and Ding X. Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa. Biochem Biophys Res Commun 1999; 266:262-267.
• Gu J, Zhang QY, Genter MB, Lipinskas TW, Nebert DW, Negishi M, and Ding X. Purification and Characterization of Heterologously Expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of 2,6-dichlorobenzonitrile and acetaminophen in mouse olfactory microsomes. J Pharmacol Exp Ther 1998; 285:1287-1295.
• Gu J, Walker VE, Lipinskas TW, Walker DM., and Ding X. Intraperitoneal administration of coumarin causes tissue-specific depletion of Cytochrome P450 and cytotoxicity of the olfactory mucosa. Toxicol Appl Pharmacol 1997; 146: 134-143.

Contact Information

Phone: 518-473-0782
Fax: 518-486-1505
E-mail: jungu@wadsworth.org

Key words: drug-metabolizing enzyme, chemical toxicity, neurodegenerative disease, kidney