Investigators and Program Directors

Select Publications

• Singh, N., Ma, Z., Gemmill, T., Wu, X., Rossettini, A., Rabeler, C., Beane, O., DeFiglio, H., Palumbo, M., Morse, R. and Hanes, S. D. (2009). The Ess1 prolyl isomerase is required for transcription termination of small non-coding regulatory RNAs via the Nrd1 pathway. Mol. Cell, (in press Oct 23)
• Matyash, A., Singh, N., Hanes, S.D. and Jäckle, H. (2009). SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation. J. Biol. Chem. 284:3012-20.
• Horner, V. L., Czank, A., Jang, J. K., Singh, N., Williams, B. C., Puro, J., Kubli, E., Hanes, S. D., McKim, K. S., Wolfner, M. F. and Goldberg, M. (2006). The Drosophila calcipressin Sarah is required for several aspects of egg activation. Current Biol. 16: 1441-1446.
• Lebrecht, D., Foehr, M., Smith, E., Lopes, F.J. P., Vanario-Alonso C. E., Reinitz, J., Burz, D. S., and Hanes, S. D. (2005). Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila. Proc. Natl. Acad. Sci. USA 102:13176-13181
• Ren, P., Chaturvedi, V. and Hanes, S. D. (2005). The Ess1 prolyl isomerase is dispensable for growth but required for virulence in Cryptococcus neoformans. Microbiology 151: 1593-1605.
• Li, H-M, Li, Z., Devasahayam, G., Gemmill, T., Chaturvedi, V., Hanes, S. D., and Van Roey, P. (2005). Structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker region that restricts domain mobility. Biochemistry 44: 6180-6189.
• Gemmill, T., Wu, X., and Hanes, S.D. (2005). Vanishingly low levels of Ess1 prolyl-isomerase activity are sufficient for growth in Saccharomyces cerevisiae. J. Biol. Chem. 280:15510-15517.
• Singh, N., Zhu, W. and Hanes, S. D. (2005). Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Devel. Biol. 278: 242-254
• Wilcox, C. B., Rossettini, A. and Hanes, S. D. (2004). Genetic interactions with CTD kinases and the CTD of RNA pol II suggest a role for ESS1 in transcription initiation and elongation in Saccharomyces cerevisiae. Genetics 167:93-105.
• Habura, A., Pawlowski, J., Hanes., S. D., and Bowser, S. S. (2004). Unexpected foraminiferal diversity revealed by small-subunit rDNA analysis of Antarctic sediment. J Euk Microbiol 51, 173-179.
• Wu, X., Rossettini, A. and Hanes, S. D. (2003). The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae. Genetics 165:1687-1702.
• Devasahayam, G., Chaturvedi, V. and Hanes, S. D., (2002). The Ess1 prolyl-isomerase is essential for growth and morphogenetic switching in Candida albicans. Genetics 160: 37-48.
• Wu, X., Chang, A., Sudol, M. and Hanes, S. D. (2001). Genetic interactions between the ESS1 prolyl-isomerase and the RSP5 ubiquitin ligase reveal opposing effects on RNA polymerase II function. Current Genetics 40: 234-242.
• Burz, D. S. and Hanes, S. D. (2001). Isolation of mutations that disrupt cooperative DNA binding by the Drosophila Bicoid protein. J. Mol. Biol. 305: 219-230.
• Zhu, W., Foehr, M., Jaynes, J. B., and Hanes, S. D. (2001). Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex interacts with Bicoid and inhibits its activity. Dev. Genes Evol. 211: 109 - 117.
• Wu, X., Wilcox, C. B., Devasahayam, G., Hackett, R.L., Arevalo-Rodriguez, M., Cardenas, M. and Hanes, S. D. (2000). The Ess1 prolyl-isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J. 19:3727-3738.
• Zhu, W. and Hanes, S.D. (2000). Identification of Drosophila Bicoid-Interacting Proteins Using a Custom Two-Hybrid Selection. Gene 245:329-339.
• Burz, D.S., Rivera-Pomar, R., Jäckle, H., and Hanes, S.D. (1998). Cooperative DNA binding by Bicoid provides a mechanism for threshold-dependent activation in the Drosophila embryo. EMBO J. 17:5998-6009.

Contact Information

E-mail: hanes@wadsworth.org