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Investigators and Program Directors

Joachim Jaeger

Joachim Jaeger

Research Scientist, Wadsworth Center,
Computational & Structural Biology

Associate Professor, School of Public Health, Biomedical Sciences

Diploma, Johannes Gutenberg University, Mainz (1986)
D.Phil., Biozentrum, University of Basel (1991)
Fogarty International Research Fellow, Yale University, (1992)
University Research Fellow and Senior Lecturer, University of Leeds (1996)

Email: jjaeger@wadsworth.org

<< Research Interests

Select Publications

  • Lin GC, Jaeger J, Sweasy JB. (2007) Loop II of DNA Polymerase ß is important in maintaining polymerization activity, fidelity, and structural integrity. Nucl.Acids.Res. (in the press)
  • Cramer J, Jaeger J, Restle T (2006) Biochemical and pre-steady-state kinetic characterization of the Hepatitis C virus RNA polymerase (NS5B-D21, HC-J4). Biochemistry, 45(11), 3610-3619.
  • Dennis CA, Baron A, Grossmann G, Mazaleyrat S, Harris M and Jaeger J. (2005) Co-translational myristoylation alters the quaternary structure of HIV-1 Nef in solution. Proteins. 60(4):658-69.
  • Starcevic D, Dalal S, Jaeger J, Sweasy JB. (2005) The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. J Biol Chem. 280, 28388-93.
  • Olivetta E, Percario Z, Fiorucci G, Mattia G, Dennis C, Jaeger J, Harris M, Romeo G, Affabris E, & Federico M (2003) HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-B activation J.Immun. 170, 1716-27.
  • O'Farrell D, Trowbridge R, Stock N, Rowlands D, Jaeger J. (2003) Co-crystal structures of HC-J4 RNA polymerase: implications for nucleotide binding and de-novo initiation. J. Mol. Biol. 326, 1025-1035.
  • Griffin SD, Clarke DS, Beales LP, Worsfold O, Evans S, Jaeger J, Harris MPG, Rowlands DJ. (2003) The p7 protein of HCV forms an ion channel that is blocked by the antiviral drug amantidine. FEBS Lett 535:1-3, 34-38.
  • Maitra M, Gudzelak A, Li SX, Matsumoto Y, Eckert KA, Jaeger J, Sweasy JB. (2002) Thr79 is a residue that governs the fidelity of DNA polB by helping to position the DNA within the active site. J Biol Chem. 277(38), 35550-60.
  • Ashcroft AE, Brinker A, Coyle J, Mayer-Hartl, Kaiser M, Jaeger J, Hartl FU, Radford SE (2002) Structural Plasticity and Non-Covalent Substrate Binding in the GroEL Apical Domain: A Study using Electrospray Ionisation Mass Spectrometry and Fluorescence Binding Studies. J Biol Chem. (accepted).
  • Shah AM, Conn DA, Li SX, Capaldi A, Jaeger J, Sweasy J (2001) A DNA Polymerase beta Mutator Mutant with Reduced Nucleotide Discrimination and Increased Protein Stability. Biochemistry 40(38):11372-81.
  • Pilling A, Rosenberg M, Willis S, Jaeger J, Cohen G, Eisenberg R, Meredith D Holzenburg A (2000) Three-dimensional structure of HSV-1 glycoprotein D at 2.4 nm resolution. J Virol. 73(9):7830-4.
  • Jaeger J, Pata JD (1999) Getting A Grip: Polymerases and their substrate complexes. Curr. Opin. Str. Biol., 9(1), 21-28.
  • Jaeger J, Restle T, Steitz T.A (1998) The Structure of HIV-1 reverse tanscriptase complexed with a RNA pseudoknot inhibitor. EMBO.J. 17(3) 4535-4542.
  • Steitz TA, Wang J, Jaeger J, Eom SH, Restle T, Jeruzalmi D. (1996) DNA and RNA polymerases - Structural Diversity and Common Mechanisms. FASEB J, Vol.10, No.6.
  • T.A. Steitz, S.J. Smerdon, J. Jaeger, C.M. Joyce (1995) A unified polymerase mechanism for non-homologous DNA and RNA polymerases. Science, 266, 2022-2025.

Book Chapters and Monographs

  • T.A.Steitz, S.Smerdon, J.Jaeger, J.Wang, L.Kohlstaedt, J.Friedman, L.Beese, P.Rice (1993) Two DNA polymerases: HIV Reverse Transcriptase and Klenow Fragment of E.coli DNA polymerase I.. In: Proceedings of the 58th Symposium on Quantitative Biology, Cold Spring Harbor, May 1993.
  • DNA and RNA polymerases: Structural diversity and common mechanisms. T.A.Steitz, J.Wang, J.Jaeger, S.H.Eom, T.Restle, D.Jeruzalmi. (1996) Progress in Biophysics & Molecular Biology, 65, 202-207.
  • J. Jaeger and JD Pata (2002). Viral RNA-directed polymerases. Structure-function Relationships of Human Pathogrenic Viruses. E.Bogner/A.Holzenburg ed., Kluwer Academic/Plenum Publishers.

Contact Information

Phone: 518-408-2225
Email: jjaeger@wadsworth.org