Investigators and Program Directors

Select Publications

• Keithly, J.S. 2007. The relic mitochondrion of Cryptosporidium parvum. IN: Hydrogenosomes and Mitosomes: Mitochondria of Eukaryotic Anaerobes , J. Tachezy (ed). Microbiology Monographs, Springer Press, Germany. (in press)
• Ctrnacta, V., F. Stejskal, J.S. Keithly, I. Hrdy. 2007. Characterization of S-adenosylhomocysteine hydrolase from Cryptosporidium parvum. FEMS Microbiol. Lett. 273: 87-95.
• Cook, T., D. Roos, M. Morada, G. Zhu, J.S. Keithly, J.E. Feagin, N. Yarlett. 2007. Divergent polyamine metabolism in the Apicomplexa. Microbiology 153: 1123-30.
• Ctrnacta, V., J.G. Ault, F. Stejskal, J.S. Keithly. 2006. Localization of pyruvate:NADP⁺ oxidoreductase in sporozoites of Cryptosporidium parvum. J. Eukaryot. Microbiol. 53: 225-231.
• Keithly, J.S., Langreth, S.G., Buttle, K.F. and Mannella, C.A. 2005. Electron tomographic and ultrastructural analysis of the Cryptosporidium parvum relict mitochondrion, its associated membranes, and organelles. J. Eukaryot. Microbiol. 52: 132-140. (Cover Photo: Four views of a three-dimensional model of the membrane surfaces in the reconstructed mitochondrion of Cryptosporidium parvum.)
• Slapeta, J.R. and J.S. Keithly. 2004. Cryptosporidium parvum (Apicomplexa) mitochondrial-type HSP70 targets homologous and heterologous mitochondria. Eukaryot. Cell 3: 483-494.
• Zhu, G., Y. Li, X. Cai, J.J. Millership, M.J. Marchewka, J.S. Keithly. 2004. Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum. Mol. Biochem. Parasitol. 134: 127-135.
• LaGier, M.J., J. Tachezy, F. Stejskal, K. Kutisova, J.S. Keithly. 2003. Mitochondrial-type iron-sulfur cluster biosynthesis genes (IscS and IscU) in the apicomplexan Cryptosporidium parvum. Microbiology 149: 3519-3530.
• Slapeta, J.R., Stejskal, F., J.S. Keithly. 2003. Characterization of S-adenosyl-methionine synthase in Cryptosporidium parvum. FEMS Microbiol. Lett. 225: 271-7.
• Riordan, C.E., J.G. Ault, S.G. Langreth. J.S. Keithly. 2003. Cryptosporidium parvum Cpn60 targets a relict organelle. Current Genetics. 44 138-147.
• Kayser, O., W.R. Waters, K.M. Woods, S.J. Upton, J.S. Keithly, H. Laatsch, A.F. Kiderlen. 2002. Evaluation of in vitro and in vivo activity of benzindazole-4,9-Quinones against Cryptosporidium parvum. J. Antimicrob. Chemother. 50: 975-980.
• Chen, X-M, J.S. Keithly, C.V. Paya, N. LaRusso. 2002. Cryptosporidiosis. Review. New England J. Med. 346: 1723-31.33.
• LaGier, M.J., G. Zhu, J.S. Keithly. 2002. A novel transporter from the apicomplexan Cryptosporidium parvum. Intl. J. Parasitol. 32: 877-87.
• Zhu, G. and J.S. Keithly. 2002. α-proteobacterial lineage of apicomplexan lactate and malate dehydrogenases. J. Euk. Microbiol. 49: 255-61.
• Kayser, O., W.R. Waters, K.M. Woods, S.J. Upton, J.S. Keithly, A.F. Kiderlen. 2001. Evaluation of in vitro activity of aurones and related compounds against Cryptosporidium parvum. Planta Medica 67: 722-725.
• Rotte, C., F. Stejskal, G. Zhu, J.S. Keithly, and W. Martin. 2001. Pyruvate:NADP+ oxidoreductase from the mitochondrion of Euglena gracilis and from the apicomplexan Cryptosporidium parvum: A biochemical relic linking pyruvate metabolism in mitochondriate and amitochondriate protists. Mol. Biol. Evol. 18: 710-720.
• Zhu, G., J.S. Keithly, H. Philippe. 2000. What is the phylogenetic position of Cryptosporidium? Intl. J. System. Evol. Microbiol. 50:1673-81.

Contact Information

E-mail: keithly@wadsworth.org.