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Investigators and Program Directors

Michael Koonce

Michael Koonce

Research Scientist, Wadsworth Center, Cellular Regulation
Adjunct Assistant Professor, School of Public Health, Biomedical Sciences

Ph.D., University of California at Berkeley (1987)
Postdoctoral training, University of Colorado at Boulder

E-mail: koonce@wadsworth.org

<< Research Interests

Select Publications

  • Koonce, M.P. 2006. Dynein shifts into second gear. Proc. Natl. Acad. Sci. (USA). 103:18587-17588
  • Meng, X., Samsó, M., and Koonce, M.P. 2006. A flexible linkage between the dynein motor and its cargo. J. Mol Biol. 357:701-706.
  • Brito, D.A., Strauss, J., Magidson, V., Tikhonenko, I. Khodjakov, A., and Koonce, M.P. 2005. Pushing forces drive the comet-like motility of microtubule arrays in Dictyostelium. Mol. Biol. Cell. 16:3334-3340.
  • Samsó, M. and Koonce, M.P. 2004. 25-Å resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring. J. Mol Biol. 340:1059-1072.
  • Koonce, M.P. and Samsó, M. 2004. Of rings and levers; the dynein motor comes of age. Trends Cell Biology. 14:612-619.
  • Koonce, M.P. and Khodjakov, A. 2002. Dynamic microtubules in Dictyostelium. J. Muscle Res. and Cell Motil. 23:613-619.
  • Asai, D.J., and Koonce, M.P. 2001. The dynein heavy chain: structure, mechanics, and evolution. Trends Cell Biology. 11:196-202.
  • Koonce, M.P. and Tikhonenko, I. 2000. Functional elements within the dynein-microtubule binding domain. Mol. Biol. Cell. 11:523-529.
  • Koonce, M.P. 2000. Dictyostelium: A model organism for microtubule-based transport. Protist. 151:17-25.
  • Koonce, M.P., Köhler, J., Neujahr, R., Schwartz, J.-M., Tikhonenko, I., and Gerisch, G. 1999. Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position. EMBO J. 18:6786-6792.
  • Habura, A., Tikhonenko, I., Chisholm, R. L., and Koonce, M.P. 1999. Interaction mapping of a dynein heavy chain: Identification of dimerization and intermediate-chain binding domains. J. Biol. Chem. 274:15447-15453.
  • Samsó, M., Radermacher, M., Frank, J., and Koonce, M.P. 1998. Structural characterization of a dynein motor domain. J. Mol. Biol. 276:927-937.

Contact Information

E-mail: koonce@wadsworth.org.