Investigators and Program Directors

Select Publications

• Hernández, G., Anderson, J.S., and LeMaster, D.M. (2010) Assessing the native state conformational distribution of ubiquitin by peptide acidity. Biophys. Chem. 153:70-82.
• Anderson, J.S., Hernández, G., and LeMaster, D.M. (2010) Sidechain conformational dependence of hydrogen exchange in model peptides. Biophys. Chem. 151:61-70.
• McNaughton, L., Tikhonenko, I., Banavali, N., LeMaster, D.M., and Koonce, M.P. (2010) A low affinity ground state conformation for the dynein microtubule binding domain. J. Biol. Chem. 285:15994-16002.
• McNaughton, L., Li, Z., Van Roey, P., Hanes, S.D., and LeMaster, D.M. (2010) Restricted domain mobility in the Candida albicans Ess1 prolyl isomerase. Biochim. Biophys Acta 1804:1537-1541.
• Anderson, J.S., Hernández, G., and LeMaster, D.M. (2010) Conformational electrostatics in the stabilization of the peptide anion. Curr. Org. Chem. 14:162-180.
• Gu, D., McNaughton, L., LeMaster, D.M., Lake, B.G., Gooderham, N.J., Kadlubar, F.F., and Turesky, R.J. (2010) A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine. Chem. Res. Toxicol. 23:788-801.
• LeMaster, D.M., Anderson, J.S., and Hernández, G. (2009) Peptide conformer acidity analysis of protein flexibility monitored by hydrogen exchange. Biochemistry 48:9256-9265.
• Hernández, G., Anderson, J.S., and LeMaster, D.M. (2009) Polarization and polarizability assessed by protein amide acidity. Biochemistry 48:6482-6494.
• Anderson, J.S., Hernández, G., and LeMaster, D.M. (2009) Backbone conformational dependence of peptide acidity. Biophys. Chem. 141:124-130.
• Anderson, J.S., Hernández, G., and LeMaster, D.M. (2008) A billion-fold range in acidity for the solvent-exposed amides of Pyrococcus furiosus rubredoxin. Biochemistry 47:6178-6188.
• Hernández, G., Anderson, J.S., and LeMaster, D.M. (2008) Electrostatic stabilization and general base catalysis in the active site of the human protein disulfide isomerase a domain monitored by hydrogen exchange. ChemBioChem 9:768-778.
• Ni, W., McNaughton, L., LeMaster, D.M., Sinha, R., and Turesky, R.J. (2008) Quantitation of thirteen heterocyclic aromatic amines in cooked beef, pork and chicken by liquid chromatography-electrospray ionization/tandem mass spectrometry. J. Agric. Food Chem. 9:56(1):68-78.
• LeMaster, D.M., Anderson, J.S., Wang, L., Guo, Y., Li, H., and Hernández, G. (2007) NMR and X-ray analysis of structural additivity in metal binding site-swapped hybrids of rubredoxin. BMC Struct. Biol. 7:81.
• LeMaster, D.M., Anderson, J.S., and Hernández, G. (2007) Spatial distribution of dielectric shielding in the interior of Pyrococcus furiosus rubredoxin as sampled in the subnanosecond timeframe by hydrogen exchange. Biophys. Chem. 129:43-48.
• LeMaster, D.M., Anderson, J.S., and Hernández, G. (2007) Normal carbon acid referencing for protein amide hydrogen exchange. Magn. Res. Chem. 45:601-604.
• Turesky, R.J., Goodenough, A.K., Ni, W.J., McNaughton, L., LeMaster, D.M., Holland, R.D., Wu, R.W., and Felton, J.S. (2007) Identification of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline: An abundant mutagenic heterocyclic aromatic amine formed in cooked beef. Chem. Res. Toxicol. 20:520-530.
• LeMaster, D.M. and Hernández, G. (2007) Residue cluster additivity of thermodynamic stability in the hydrophobic core of mesophile vs. hyperthermophile rubredoxins. Biophys. Chem. 125:483-489.
• Anderson, J.S., LeMaster, D.M., and Hernández, G. (2006). Electrostatic potential energy within a protein monitored by metal charge-dependent hydrogen exchange. Biophys. J. 91:L91-L93.
• LeMaster, M. and Hernández, G. (2006) Additivity of differential conformational dynamics in hyperthermophile/mesophile rubredoxin chimeras as monitored by hydrogen exchange. ChemBioChem 7:1886-1889.
• LeMaster, D.M., Minnich, M., Parsons, P.J., Anderson, J.S., and Hernández, G. (2006) Tetrathiolate coordination of germanium(IV) in a protein active site. J. Inorg. Biochem. 100:1410-1412.
• LeMaster, D.M., Anderson, J.S., Hernández, G. (2006) Role of native-state structure in rubredoxin native-state hydrogen exchange. Biochemistry 45:9956-9963.
• LeMaster, D.M. (2006) Heat capacity-independent determination of differential free energy of stability between structurally homologous proteins. Biophys. Chem. 119:94-100.
• LeMaster, D.M. and Hernández, G. (2007) Residue cluster additivity of thermodynamic stability in the hydrophobic core of mesophile vs. hyperthermophile rubredoxins. Biophys. Chem. 125:483-489.
• Anderson, J.S., LeMaster, D.M., and Hernández, G. (2006). Electrostatic potential energy within a protein monitored by metal charge-dependent hydrogen exchange. Biophys. J. 91:L91-L93.
• LeMaster, M. and Hernández, G. (2006) Additivity of differential conformational dynamics in hyperthermophile/mesophile rubredoxin chimeras as monitored by hydrogen exchange. ChemBioChem 7:1886-1889.
• LeMaster, D.M., Minnich, M., Parsons, P.J., Anderson, J.S., and Hernández, G. (2006) Tetrathiolate coordination of germanium(IV) in a protein active site. J. Inorg. Biochem. 100:1410-1412.
• LeMaster, D.M., Anderson, J.S., Hernández, G. (2006) Role of native-state structure in rubredoxin native-state hydrogen exchange. Biochemistry 45:9956-9963.

Invited book chapter:

• Hernández, G. and LeMaster, D.M. NMR Analysis of Native State Protein Conformational Flexibility by Hydrogen Exchange. Methods in Molecular Biology, 2009, 490, 285-310. Protein Structure, Folding and Interactions ed. Shriver, J.W. (Humana Press).
• Hernández, G., Anderson, J.S., and LeMaster, D.M. Electrostatics of Hydrogen Exchange for Analyzing Protein Flexibility. Methods in Molecular Biology, 2011, submitted. Ed. Shektman, A. and Burz, D.S. (Humana Press).

Contact Information

Phone: (518) 474-6396
Fax: (518) 473-2900
E-mail: lemaster@wadsworth.org