Investigators and Program Directors

Select Publications

• LM Wang, YW Zhao, Zh. Li, Y. Guo, D.M. Kranz, W Mourad, H. Li (2007), Structure of a complete ternary complex between TCR, superantigen, and Class II MHC molecule, Nature Structure & Molecular Biology 14, 169-171.
• Li, HM, Zhao, YW, Guo, Y., Li, Z., Eisele, L., and Mourad, W. (2007), Zinc induces dimerization of the class II MHC molecule that leads to cooperative binding to a superantigen J. Biol. Chem., 282, 5991-6000.
• Zhou Y, Ray D, Zhao Y, Dong H, Ren S, Li Z, Guo Y, Bernard KA, Shi PY & Li HM (2007). Structure and function of flavivirus NS5 methyltransferase. J Virol. 81, 3891-3903.
• H. Li, Y.W. Zhao, Y. Guo, S.J. VanVranken, Zh. Li, L. Eisele, W. Mourad (2007), Mutagenesis, biochemical, and biophysical characterization of Mycoplasma arthritidis-derived mitogen, Mol. Immunol., 44, 763-773.
• Dong HP, Ray D, Ren SP, Zhang B, Puig-Basagoiti F, Takagi Y, Ho K, Li HM & Shi PY (2007), Distinct RNA elements confer specificity to flavivirus RNA cap methylation events, J. Virol. 81, 4412-4421.
• D. Ray, A. Shah, YW Zhao, M. Tilgner, Y. Guo, HP Dong, T.S. Deas, H. Li, and PY Shi (2006), West Nile Virus 5'-Cap Structure is Formed through Sequential Methylations of Guanine N-7 and Ribose 2'-OH positions by Non-Structural Protein 5, J. Virol. 80, 8362-70.
• Guo Y, Li Z, Van Vranken SJ, Li H. (2006), A single point mutation changes the crystallization behavior of Mycoplasma arthritidis-derived mitogen. Acta Crystallograph F62, 238-41.
• Li, H., Vranken, SV, Zhao, Y, Li, Zh, Guo, Y, Eisele, E, Li, Y (2005). Crystal structures of T cell receptor ß chains related to rheumatoid arthritis, Protein Science 14, 3025-38.
• Li, Zh., Li, H., Devasahayam, G., Gemmill, T., Chaturvedi, V., Hanes, S., Van Roey, P. (2005), The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobility, Biochemistry, 44, 6180-6189.
• Zhao, Y., Li, Zh., Drozd, SJ, Guo, Y., Mourad, W, and Li, H. (2004), Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex, Structure, 12, 277-88.
• Zhao, Y., Li, Zh., Drozd, SJ, Guo, Y., Stack, R., Hauer, C. and Li, H. (2004), Crystallization and preliminary crystallographic analysis of Mycoplasma arthritidis-derived mitogen complexed with peptide/MHC class II antigen, Acta Crystallography D60, 353-6.
• Li, Y., Li, H., Yang, F., Smith-Gill, S.J., and Mariuzza, RA (2003). X-ray snapshots of the maturation of an antibody response to a protein antigen. Nat Struct Biol. 10, 482-488.
• Wang H, Lee HK, Bukowski JF, Li H, Mariuzza RA, Chen ZW, Nam KH, Morita CT. (2003). Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells. J Immunol. 170:3696-706.
• Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. (2003). Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol. 41, 4217-23.
• Zeng ZH, He XL, Li H., Hu Z, Wang DC. (2003). Crystal structure of pokeweed antiviral protein with well-defined sugars from seeds at 1.8Å resolution. J Struct Biol. 141, 171-8.
• Lu L, Lamm ME, Li H, Corthesy B, Zhang JR. (2003). The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J Biol Chem. 278:48178-87.
• Li, H., Ryan, T.J., Chave, K.J. and Van Roey, P. (2002). Three-dimensional structure of human γ-glutamyl hydrolase: a class I glutamine amidotransferase adapted for a complex substrate, J. Biol. Chem. 277, 25422-25429.
• Sundberg, E.J., Li, H., Llera, A.S., McCormick, J.K., Tomo, J., Schlievert, P.M., Karjalainen, K. and Mariuzza, R.A. (2002). Crystal structures of two streptococcal superantigens complexed with their TCR ß chain ligands reveal distinct TCR binding modes and a novel T cell signaling complex, Structure 10, 687-699.
• Etongue-Mayer P, Langlois MA, Ouellette M, Li H, Younes S, Al-Daccak R and Mourad W. (2002). Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the ß chain. Eur J Immunol. 32, 50-58.
• Zhang X, Su T, Zhang QY, Gu J, Caggana M, Li H, Ding X. (2002). Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. J Pharmacol Exp Ther. 302, 416-23.
• Morita, C.T., Lee, H.K., Wang, H., Li, H., Mariuzza, R.A. and Tanaka, Y. (2001) Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human γδ T cells, J. Immunol. 167, 36-41.
• Li, Y., Li, H., Dimasi, N., McCormick, J.K., Martin, R., Schuck, P., Schlievert, P.M. and Mariuzza, R.A. (2001). Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity 14, 93-104.
• Morita, C., Li, H., Lamphear, J.G., Rich, R.R., Fraser, J.D., Mariuzza, R.A. and Lee, H.K. (2001). Superantigen recognition by γδ T cells: SEA recognition site for human Vγ2 T cell receptors, Immunity 14, 331-344.
• He, X.-L., Liu, X.-Q., Zeng, Z.-H., Li, H., Wang, M., Zhang, Y. and Wang, D.C. (2000). Crystal structure determination of a neutral neurotoxin BmK M4 from Buthus martensii Karsch at 0.2nm. Science in China C Life Science C43, 39-46.
• Li, Y., Li, H., Martin, R. and Mariuzza, R.A. (2000). Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins, J. Mol. Biol., 304, 177-188.
• Li, Y., Li, H., Smith, S. and Mariuzza, R.A. (2000). Three-dimensional structures of the free and the antigen-bound Fab from monoclonal anti-lysozyme antibody HyHEL-63. Biochemistry 39, 6296-9309.
• Li, H., Llera, A.S., Malchiodi, E.L. and Mariuzza, R.A. (1999). The structural basis of T cell activation by superantigens. Annual Review of Immunology 17, 435-466.
• Li, H., Lebedeva, M.I., Llera, A.S., Fields, B.A., Brenner, M.B. and Mariuzza, R.A.. (1998). Structure of the Vδ domain of a human γδ T cell antigen receptor. Nature 391, 502-506.
• Li, H., Llera, A.S., Leder, L., Tsuchiya, D., Ysern, X., Schlievert, P.M., Karjalainen, K. and Mariuzza, R.A. (1998). Three-dimensional structure of the complex between a T-cell receptor ß-chain and the superantigen SEB. Immunity 9, 807-816.
• Fields, B.A., Malchiodi, E.L., Li, H., Ysern, X., Stauffacher, C.V., Schlievert, P.M., Karjalainen, K. and Mariuzza, R.A. (1996). Crystal structure of a T cell receptor ß-chain complexed with superantigen SEC3. Nature 384, 188-192.

Contact Information

Phone: 518-486-9154
Fax: 518-408-2190
E-mail: lih@wadsworth.org