Investigators and Program Directors

Research Interests

Our laboratory studies spirochetes which are a unique group of spiral-shaped bacteria. These include pathogenic spirochetes that are the causative agent of syphilis and Lyme disease as well as non-pathogenic species that are used as models to study pathogenic spirochetes. Our model organism, Treponema denticola is associated with periodontal disease. Many of our studies have focused on motility genes because of the important role of motility in pathogenesis of spirochetes. We continue to develop genetic tools to determine the function of unknown genes that may be associated with motility. We also explore the function and regulation of genes encoding polypeptides involved in the structure and survival of spirochetes. Our recent project is a collaborative effort to understand the role of non-heme iron containing enzymes in determining the cellular response to oxidative and nitrosative stress. Our approach is to create and analyze mutants that are deficient in key polypeptides using a genetic approach. The ultimate aim of research of spirochetes is to understand pathogenic mechanisms as a basis for developing a safe and effective vaccine. Disruption of the ability of spirochetes to move, grow or tolerate aerobic stresses may prove to be an effective vaccine strategy.

As Deputy Director of Infectious Disease, I am administratively involved in the activities of this Division as well continuing the basic research studies.

Contact Information

E-mail:limberg@wadsworth.org