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Investigators and Program Directors

Frank Maley

Research Scientist Emeritus, Wadsworth Center

Ph.D., University of Wisconsin (Madison)
Postdoctoral training, New York University Medical School

E-mail: maley@wadsworth.org

<< Research Interests

Select Publications

  • Roberts, S.A., Hyatt, D.C., Honts, J.E., Changchien, L.-M., Maley, G.F., Maley, F. and Montfort, W.R. (2006) Structure of Y94F mutant of Escherichia coli thymidylate synthase. Acta. Cryst. F62, 840-843.
  • Sotelo-Mundo, R.R., Changchien, L.-M., Maley, F., and Montfort, W.R. (2006) Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss in catalytic activity. J. Biochem. Molec. Toxic. 20, 88-92.
  • Hong, B., Haddad, M., Maley, F., and Kohen, A. (2006) Hydride transfer vs hydrogen radical transfer in E. coli thymidylate synthase. J. Am. Chem. Soc. 128, 5636-5637.
  • Almog, R., Maley, F., Maley, G.F., MacColl, R., and Van Roey, P. (2004) Three dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxy-cytidylate deaminase. Biochemistry 43, 13715-13723.
  • Capiaux, G.M., Budak-Alpodgan, T., Alpdogan, O., Bornmann, W., Takabe, N., Banerjee, D., Maley, F., and Bertino, J.R. (2004) Protection of hematopoetic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene. Cancer Gene Ther 11, 767-773.
  • West, D.K., Porter, D.C., Saxl, R.L. and Maley, F. (2004) A trojan horse approach for silencing thymidylate synthase. Biochemistry 43, 9177-9184.
  • Capiaux, G.M., Alpdogan, T.B., Takebe, N., Kuckuk, P.M., Banerjee, D., Maley, F., and Bertino, J.R. (2003) Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil. Human Gene Ther. 14, 435-446.
  • Saxl, R., Reston, J., Zhe, N., Kalman, T.I., and Maley, F. (2003) Modification of Escherichia coli thymidylate synthase at tyrosine-94 by 5-imidazolyl propynyl-2'-deoxyuridine 5'-monophosphate. Biochemistry 42, 4544-4551.
  • Gribaudo, G., Riera, L., Caposio, P., Maley, F., and Landolfo, S. (2003) Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells. J. Gen. Viol. 84, 1437-1441.

Contact Information

E-mail: maley@wadsworth.org