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Investigators and Program Directors

The Mannella Group

Carmen A. Mannella

Research Scientist, Wadsworth Center, Cellular and Molecular Basis of Diseases
Professor, School of Public Health, Biomedical Sciences

Ph.D., University of Pennsylvania (1974)
Postdoctoral training, Roswell Park Memorial Institute and St. Louis University

E-mail: carmen@wadsworth.org.

<< Research Interests

Select Publications

  • Hiller, S., Abramson, J., Mannella, C., Wagner, G., and Zeth, K. (2010) The 3D structures of VDAC represent a native conformation. Trends Biochem. Sci. 35:514-521.
  • Renken, C., Hsieh, C., Marko, M., Rath, B., Leith, A., Wagenknecht, T., Frank, T., Mannella, C.A. (2009) Structure of frozen-hydrated triad junctions: A case study in motif searching inside tomograms [with cover] J. Struct. Biol. 165:53-63.
  • LaRocca, T.J., Holthausena, D.J., Hsieh, C., Renken, C., Mannella, C.A., Benach, J.L. (2009) The bactericidal effect of a complement-independent antibody is osmolytic and specific to Borrelia.Proc. Natl. Acad. Sci. USA 106:10752-10757.
  • Lu, Z., Shaikh, T.R., Barnard, D., Meng., X., Mohamed, H., Yassin, A., Mannella, C.A., Agrawal., R.K., Lu, T.-M., Wagenknecht, T. (2009) Monolithic microfluidic mixing-spraying devices for time-resolved cryo-electron microscopy. J. Struct. Biol. 168:388-395.
  • Mannella, C.A. (2008) Structural diversity of mitochondria: Functional implications. Ann. NY Acad. Sci. 1147:171-179.
  • Kanazawa, T., Zappaterra M.D., Hasegawa A., Wright A.P., Newman-Smith E.D., Buttle, K.F., McDonald, K., Mannella, C.A., and van der Bliek, A. (2008) The C. elegans Opa1 homologue EAT-3 Is essential for resistance to free radicals. PLoS Genet 4(2): e1000022.
  • Marko, M, Hsieh, C., Schalek, R. Frank, J., and Mannella, C. (2007) Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nature Methods 4:215-217.
  • Mannella, C.A. (2006a) The relevance of mitochondrial membrane topology to mitochondrial function. Biochim. Biophys. Acta 1762:140-147.
  • Mannella, C.A. (2006b) Structure and dynamics of mitochondrial inner membrane cristae. Biochim. Biophys. Acta 1763:542-548.
  • Csordás, G., Renken, C., Várnai, P., Walter, L., Weaver, D., Buttle, K.F., Balla, T., Mannella, C.A., and Hajnóczky, G. (2006) Structural and functional features and significance of the physical linkage between ER and mitochondria. J. Cell Biol. 174:915-921.
  • Celotto, A.M., Frank, A.C., McGrath, S.W., Fergestad, T., Van Voorhies, W.A., Buttle, K.F., Mannella, C.A., and Palladino, M.J. (2006) Mitochondrial encephalomyopathy in Drosophila. J. Neurosci. 26:810-820.
  • Hsieh, C.-E., Marko, M., Leith, A., Mannella, C.A., and Frank, J. (2006) Towards high-resolution three-dimensional imaging of native mammalian tissue: Electron tomography of frozen-hydrated rat liver sections. J. Struct. Biol. 153:1-13.
  • Scorrano, L., Ashiya, M., Buttle, K., Weiler S., Mannella, C.A., and Korsmeyer, S.J. (2002) A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell 2:55-67.
  • Deng, Y., Kohlwein, S.D., and Mannella, C.A. (2002) Fasting induces cyanide-resistant respiration and oxidative stress in the amoeba Chaos carolinensis: Implications for the cubic structural transition in mitochondrial membranes. Protoplasma 219:160-167.

Contact Information

E-mail: carmen@wadsworth.org