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Investigators and Program Directors

Nicholas Mantis

Nicholas J. Mantis

Research Scientist, Wadsworth Center, Immunology and Infectious Diseases
Associate Professor and Chair, Department of Biomedical Sciences, School of Public Health

Ph.D., Cornell University (1994)
Postdoctoral Training, Pasteur Institute (Paris), Children's Hospital Boston, and Harvard Medical School


<< Research Interests

Select Publications

  • J. M. O’Hara, K Whaley, M Pauly, L Zeitlin and NJ Mantis,‡. 2012 Plant-based Expression of a Partially Humanized Neutralizing Monoclonal IgG Directed against an Immunodominant Epitope on the Ricin Toxin A Subunit Vaccine. Vaccine 8;30(7):1239-43. Epub 2011 Dec 22. PMID: 22197964
  • Forbes SJ, D Martinelli, C Hsieh, JG Ault, M Marko, CA. Mannella, and NJ Mantis.(2012) Association of a Protective Monoclonal IgA with the O-Antigen of Salmonella enterica serovar Typhimurium Impacts Type 3 Secretion and Outer Membrane Integrity Infection and Immunity. Jul;80(7):2454-63 PMID: 22473607
  • DJ Vance and NJ Mantis (2012) Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant a-helix in ricin Toxin's enzymatic subunit. Toxicon Oct;60(5):874-7. (Jun 29. [Epub ahead of print]) PMID: 22750533
  • A Yermakova, DJ Vance, and NJ Mantis*. (2012). Sub-Domains of Ricin's B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies PLoS ONE (published 11 Sep 2012 10.1371/journal.pone.0044317) PMID: 22984492
  • AM Stringer, N Singh, A. Yermakova, BL Petrone, J Amarasinghe, L Reyes-Diaz, NJ Mantis and J T Wade. (2012) FRUIT, a Scar-Free System for Targeted Chromosomal Mutagenesis, Epitope Tagging, and Promoter Replacement in Escherichia coli and Salmonella enterica. PLoS ONE 7(9):e44841. doi: 10.1371/journal.pone.0044841. Epub 2012 Sep 27 PMID: 23028641
  • M De Jesus, S Alhawat, and NJ Mantis (in press) Isolation and immunostaining of murine Peyer’s patch lymphocytes. (Journal of Visualized Experiments). PMID: pending
  • P. Wahome, S. Ahlawat and NJ. Mantis*. (2012) "Identification of Small Molecules that Suppress Ricin-Induced Stress-Activated Signaling Pathways" PLoS ONE 7(11):e49075. PMID: pending
  • Folding domains within the ricin toxin A subunit as targets of protective antibodies. (2010) O'Hara JM, Neal LM, McCarthy EA, Kasten-Jolly JA, Brey RN 3rd, Mantis NJ. Vaccine. 2010 Aug 18. [Epub ahead of print]
  • P.Wahome, Y. Bai, L Neal, J. Robertus and NJ Mantis (2010) Identification of small molecule inhibitors of ricin and shiga toxin using a high-throughput cell based screen. Toxicon 39(4-5):383-406. PubMed
  • J Baumann, CG Park and NJ Mantis (2010) Recognition and internalization of secretory IgA by DC-SIGN: Implications for immune surveillance in the intestine. Immunology Letters 131(1):59-66. PubMed.Epub 2010 Mar 31.
  • NJ Mantis and SF Forbes (2010) Secretory IgA: Arresting microbial pathogens at mucosal surfaces. Immunological Investigations 39(4-5):383-406. PubMed.
  • NJ Mantis, L Morici, C Roy (In press) Mucosal vaccines for biodefense in Mucosal Vaccines: ed. Pamela Kozlowski. Springer-Verlag.
  • L Neal, J O'Hara, R Brey, and NJ Mantis 2010 A monoclonal antibody against an immunodominant epitope on ricin A chain is confers both systemic and mucosal immunity to ricin. Infection and Immunity 78:552-61 Epub October 26, 2009 PMID: 19858297

Contact Information

Division of Infectious Disease
Wadsworth Center
New York State Department of Health
120 New Scotland Avenue
Albany, NY 12208
Phone: (518) 473-7487
Facsimile: (518) 402-4773

Key Words: Microbial pathogenesis; toxin; mucosal immunology; antibody