Investigators and Program Directors

Select Publications

• Folding domains within the ricin toxin A subunit as targets of protective antibodies. (2010) O'Hara JM, Neal LM, McCarthy EA, Kasten-Jolly JA, Brey RN 3rd, Mantis NJ. Vaccine. 2010 Aug 18. [Epub ahead of print] http://preview.ncbi.nlm.nih.gov/pubmed/20727394
• P.Wahome, Y. Bai, L Neal, J. Robertus and NJ Mantis (2010) Identification of small molecule inhibitors of ricin and shiga toxin using a high-throughput cell based screen. Toxicon 39(4-5):383-406. PubMed
• J Baumann, CG Park and NJ Mantis (2010) Recognition and internalization of secretory IgA by DC-SIGN: Implications for immune surveillance in the intestine. Immunology Letters 131(1):59-66. PubMed.Epub 2010 Mar 31.
• NJ Mantis and SF Forbes (2010) Secretory IgA: Arresting microbial pathogens at mucosal surfaces. Immunological Investigations 39(4-5):383-406. PubMed.
• NJ Mantis, L Morici, C Roy (In press) Mucosal vaccines for biodefense in Mucosal Vaccines: ed. Pamela Kozlowski. Springer-Verlag.
• L Neal, J O'Hara, R Brey, and NJ Mantis 2010 A monoclonal antibody against an immunodominant epitope on ricin A chain is confers both systemic and mucosal immunity to ricin. Infection and Immunity 78:552-61 Epub October 26, 2009 PMID: 19858297
• C Kelly and NJ Mantis 2009 Neutralizing monoclonal antibodies against defined linear epitopes on domain 4 of anthrax protective antigen. Infection and Immunity 77: 4859-67. Epub 2009 Aug 24. PMID: 1970397
• S.Forbes, M. Eschmann, and NJ Mantis. (2008) Inhibition of Salmonella Motility and Entry into Epithelial Cells by a Protective Anti-Lipopolysaccharide Monoclonal IgA Antibody. Infection and Immunity. 76:4137-44 PubMed. This manuscript was highlighted as an Editor's Choice
• Mantis, N.J., AJ. Hessell, J.Palaia, S.Mehta, Z.Zhu, B.Corthésy, M. R. Neutra, D.R. Burton, E.N. Janoff 2007 "Inhibition of HIV-1 Infectivity and Epithelial Cell Transfer by Monoclonal Antibody b12" The Journal of Immunology179 (5) 3144-52. PubMed
• Yoder, JM. RA Aslam, and N.J. Mantis (2007) Murine model of intestinal ricin intoxication: Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein-1. Infection and Immunity 75:1745-50. PubMed
• C.R.McGuinness and N.J.Mantis. (2006) Characterization of a Novel High-Affinity Monoclonal IgG Antibody against the Ricin B Subunit. Infection and Immunity, 74:3463-70. PubMed
• N.J. Mantis, C. McGuinness, O.Sonuyi, G. Edwards, and S.A. Farrant. (2006) IgA Antibodies against Ricin A and B Subunits Protect Epithelial Cells from Ricin Intoxication.  Infection and Immunity 74:3455-62. PubMed
• Gonzalez,T.V., S.A. Farrant and N.J. Mantis. (2006) Ricin induces IL-8 secretion in human monocyte/macrophages by activating the p38 MAP kinase pathway. Molecular Immunology . 43(11):1920-3. PubMed
• Mantis, N.J. and B. Corthesy. IgA and antigen transport. In Mucosal Immune Defense: IgA (Springer-Verlag) edited by C. Kaetzel. In press.
• Mantis, N.J. (2005) Vaccines against Category B enterotoxins. Advanced drug delivery reviews (Special Issue on Vaccines against Bioterrorism Agents). 57(9):1424-39. PubMed
• Mantis, N.J. and J. Wagner (2004) Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells. J. Drug Targeting (special issue on Cellular Aspects of Targeting in the Gastrointestinal Tract) 12(2), 79-87. PubMed
• Mantis, N.J., S. Mehta and S.A. Farrant (2004) Oligosaccharide side chains on human secretory IgA sever as receptors for ricin. J. Immun. 172(11), 6838-6845. PubMed
• Helander, A., K.J. Silvey, N.J. Mantis, A.B. Hutchings, K. Chandran, W.T. Lucas, M.L. Nibert, and M.R. Neutra (2003) The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces. J. Virol. 77, 7964-7797. PubMed
• Mantis, N.J., M.C. Cheung, J. Rey, B. Corthesy, K. Chintalacharuvu, and M.R. Neutra (2002) Selective adhesion of immunoglobulin A to murine intestinal M cells: Evidence for a novel IgA receptor. J. of Immun. 169, 1844-1851. PubMed
• Neutra MR, Mantis N.J., Kraehenbuhl JP. (2001) Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nature Immunology 2:1004-9. PubMed
• Mantis, N.J., P. Kozlowski, D. Mielcarz, W. Weissenhorn, and M.R. Neutra (2001) Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies. Vaccine 19, 3990-4001. PubMed
• Mantis, N.J., A. Frey, and M.R. Neutra (2000) Accessibility of glycolipids and oligosaccharide epitopes on rabbit villus and follicle-associated epithelium. Am. J. Physiol. 278, G915-G923. PubMed
• Frey, A., N.J. Mantis, P.A. Kozlowski, A.J. Quayle, A. Bajardi, F.A. Robey, and M.R. Neutra (1999) Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles. Vaccine 17, 3007-3019. PubMed
• Skoudy, A., G. Tran Van Nhieu, N.J. Mantis, M. Arpin, J. Mounier, P. Gounon, and P.J. Sansonetti (1999) A functional role for ezrin during Shigella flexneri entry into epithelial cells. J. Cell Sci. 112, 2059-2068. PubMed
• Mantis, N.J., M.C. Prévost and P.J. Sansonetti (1996) Analysis of the epithelial cell stress response during infection by Shigella flexneri. Infection and Immunity 64, 2474-2482. PubMed

Contact Information

Division of Infectious Disease
Wadsworth Center
New York State Department of Health
120 New Scotland Avenue
Albany, NY 12208
Phone: (518) 473-7487
Facsimile: (518) 402-4773
E-mail: nmantis@wadsworth.org

Key Words: Microbial pathogenesis; toxin; mucosal immunology; antibody