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Investigators and Program Directors

Paul Masters

Paul Masters

Research Scientist, Wadsworth Center, Microbial Genetics
Associate Professor, School of Public Health, Biomedical Sciences

Ph.D., Brandeis University
Postdoctoral training, University of California at Santa Barbara and Roche Institute of Molecular Biology

E-mail: masters@wadsworth.org

<< Research Interests

Select Publications

  • Züst, R., Miller, T.B., Goebel, S.J., Thiel, V. and Masters, P.S. (2008) Genetic interactions between an essential 3' cis-acting RNA pseudoknot, replicase gene products, and the extreme 3' end of the mouse coronavirus genome. Journal of Virology 82:1214-1228.
  • Goebel, S.J., Taylor, J., Barr, B.C., Kiehn, T.E., Castro-Malaspina, H.R., Hedvat, C.V., Rush-Wilson, K.A., Kelly, C.A., Davis, S.W., Samsonoff, W.A., Hurst, K.R., Behr, M.J., and Masters, P.S. (2007) Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Journal of Virology 81:12709-12714.
  • Kuo, L., Hurst, K.R., and Masters, P.S. (2007) Exceptional flexibility in the sequence requirements for coronavirus small envelope protein function. Journal of Virology 81:2249-2262.
  • Goebel, S.J., Miller, T.B., Bennett, C.J., Bernard, K.A., and Masters, P.S. (2007) A hypervariable region within the 3' cis-acting element of the murine coronavirus genome is nonessential for RNA synthesis but affects pathogenesis. Journal of Virology 81:1274-1287.
  • Masters, P.S. (2006) The molecular biology of coronaviruses. Advances in Virus Research 66:193-292.
  • Hurst, K.R., Kuo, L., Koetzner, C.A., Ye, R., Hsue, B., and Masters, P.S. (2005) A major determinant for membrane protein interaction localizes to the carboxy-terminal domain of the mouse coronavirus nucleocapsid protein. Journal of Virology 79:13285-13297.
  • Masters, P.S., and Rottier, P.J.M. (2005) Coronavirus reverse genetics by targeted RNA recombination. Current Topics in Microbiology and Immunology 287:133-159.
  • Ye, R., Montalto-Morrison, C., and Masters, P.S. (2004) Genetic analysis of determinants for spike glycoprotein assembly into murine coronavirus virions: distinct roles for charge-rich and cysteine-rich regions of the endodomain. Journal of Virology 78:9904-9917.
  • Goebel, S.J., Taylor, J., and Masters, P.S. (2004) The 3' cis-acting genomic replication element of the severe acute respiratory syndrome coronavirus can function in the murine coronavirus genome. Journal of Virology 78:7846-7851.
  • Goebel, S.J., Hsue, B., Dombrowski, T.F., and Masters, P.S. (2004) Characterization of the RNA components of a putative molecular switch in the 3' untranslated region of the murine coronavirus genome. Journal of Virology 78:669-682.
  • Kuo, L., and Masters, P.S. (2003) The small envelope protein E is not essential for murine coronavirus replication. Journal of Virology 77:4597-4608.
  • de Haan, C.A.M., Volders, H., Koetzner, C.A., Masters, P.S., and Rottier, P.J.M. (2002) Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization. Journal of Virology 76:12491-12502.
  • de Haan, C.A.M., Masters, P.S., Shen, X., Weiss, S., and Rottier, P.J.M. (2002) The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host. Virology 296:177-189.
  • Kuo, L., and Masters, P.S. (2002) Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus. Journal of Virology 76:4987-4999.
  • Shen, X., and Masters, P.S. (2001) Evaluation of the role of heterogeneous nuclear ribonucleoprotein A1 as a host factor in murine coronavirus discontinuous transcription and genome replication. Proceedings of the National Academy of Sciences USA 98:2717-2722.
  • Hsue, B., Hartshorne, T., and Masters, P.S. (2000) Characterization of an essential RNA secondary structure in the 3' untranslated region of the murine coronavirus genome. Journal of Virology 74:6911-6921.
  • Kuo, L., Godeke, G.-J., Raamsman, M.J.B., Masters, P.S., and Rottier, P.J.M. (2000) Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. Journal of Virology 74:1393-1406.
  • Hsue, B., and Masters, P.S. (1999) Insertion of a new transcriptional unit into the genome of mouse hepatitis virus. Journal of Virology 73:6128-6135.
  • Masters, P.S. (1999) Reverse genetics of the largest RNA viruses. Advances in Virus Research 53:245-264.
  • Fischer, F., Stegen, C.F., Masters, P.S., and Samsonoff, W.A. (1998) Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly. Journal of Virology 72:7885-7894.
  • Hsue, B., and Masters, P.S. (1997) A bulged stem-loop structure in the 3' untranslated region of the genome of the coronavirus mouse hepatitis virus is essential for replication. Journal of Virology 71:7567-7578.

Contact Information

E-mail: masters@wadsworth.org