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Investigators and Program Directors

Kathleen A. McDonough

Research Scientist, Wadsworth Center, Microbial Genetics
Associate Professor, School of Public Health, Biomedical Sciences

Ph.D., Stanford University
Postdoctoral training, Howard Hughes Medical Institute, Albert Einstein College of Medicine

<< Research Interests

Select Publications

  • Gazdik MA, G. Bai, Y. Wu, K.A. McDonough. 2009. Rv1675c (cmr) regulates intramacrophage and cyclic AMP-induced gene expression in Mycobacterium tuberculosis- complex mycobacteria. Mol Microbiol. 71(2):434-48. PMID: 19040643
  • Bai, G., D.D. Schaak, and K.A. McDonough. 2009. cAMP levels within Mycobacterium tuberculosis and M. bovis BCG increase upon infection of macrophages. FEMS Immunol Med Microbiol. 55(1):68-73. PMCID: PMC2168296
  • Vasudeva-Rao, H.M. and K.A. McDonough. 2008. Expression of the Mycobacterium tuberculosis acr-coregulated genes (ACGs) from the DevR/DosR regulon is controlled by multiple levels of regulation. Infection & Immunity. 76(6): 2478-2489.
  • Banas, J.A., J.D. Miller, M.E. Fuschino, K.R. Hazlett, W. Toyofuku, K.A. Porter, S.B. Reutzel, M.A. Florczyk, K.A. McDonough, S.M. Michalek. 2007. Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutation. Applied & Environmental Microbiology. 73(1): 357-361.
  • Bai, G., M. Gazdik, D. Schaak and K. A. McDonough. 2007. Mycobacterium bovis BCG CRP-like protein (CRPBCG) is functional in vitro and in vivo, but its activity differs from that of its M. tuberculosis ortholog Rv3676 (CRPMt). Infection and Immunity. 75(11): 5509-5517.
  • Bai, G., E. Smith, A. Golubov, J. Pata and K.A. McDonough. 2007. Differential gene regulation in Yersinia pestis versus Y. pseudotuberculosis: effects of hypoxia and potential role of a plasmid regulator, Advances in Experimental Medicine and Biology. 603:131-144.
  • Woron A.M., E.J. Nazarian, C. Egan, K.A. McDonough, N.M. Cirino, R.J. Limberger, K.A. Musser. (2006). Development and evaluation of a 4-target multiplex real-time polymerase chain reaction assay for the detection and characterization of Yersinia pestis. Diagn Microbiol Infect Dis. 56(3): 261-268.
  • Shao, Y., Y. Wu, C. Y. Chan, K. McDonough and Y. Ding. 2006. Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation. Nucleic Acids Research 34(19):5660-5669.
  • Bai, G., L. A. McCue and K. A. McDonough. 2005. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 187: 7795-7804.
  • Gazdik, M. A. and K. A. McDonough. 2005. Identification of cAMP regulated genes in Mycobacterium tuberculosis complex bacteria under low oxygen conditions. J. Bacteriol. 187: 2681-2692.
  • Lease, R.A., D. Smith, K. A. McDonough, and M. Belfort. 2004. The Small Noncoding DsrA RNA Is an Acid Resistance Regulator in Escherichia coli. J. Bacteriol. 186: 6179-6185.
  • Florczyk, M.A., L.A. McCue, A. Purkayastha, E. Currenti, M.J. Wolin and K. A. McDonough. 2003. A family of acr-coregulated Mycobacterium tuberculosis genes shares a common DNA motif and requires Rv3133c (dosR or devR) for expression. Infect. Immun. 71 : 5332-5343.
  • Deng, W., V. Burland, G. Plunkett III, A. Boutin, G.F. Mayhew, P. Liss, N.T. Perna, D.J. Rose, B. Mau, D.C. Schwartz, S. Zhou, J. D. Fetherston, L. E. Lindler, R. R. Brubaker, G. V. Plano, S. C. Straley, K. A. McDonough, M. L. Nilles, J. S. Matson, F. R. Blattner, and R. D. Perry. 2002. Genome sequence of Yersinia pestis KIM. J. Bacteriology. 184: 4601-4611.
  • Purkayastha, A. P., L. A. McCue, and K. A. McDonough. 2002. Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr gene within macrophages, in standing versus shaking cultures, and low oxygen conditions. Infect. Immun. 70: 1518-1529.
  • Florczyk, M. A., L. A. McCue, R. F. Stack, C. R. Hauer, and K. A. McDonough. 2001. Identification and characterization of mycobacterial proteins differentially expressed under standing versus shaking conditions, including Rv2623 from a novel class of putative ATP-binding proteins. Infect. Immun. 69: 5777 - 5785.
  • McDonough, K. A., M. A. Florczyk, and Y. Kress. 2000. Intracellular passage within macrophages affects the trafficking of virulent tubercle bacilli upon reinfection of other macrophages in a serum-dependent manner. Tubercle and Lung Disease. 80: 259-271.
  • McCue, L.A., K.A. McDonough and C.E. Lawrence. 2000. Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis. Genome Research 10:204-219.
  • Hare, J. M., A. Wagner and K.A. McDonough. 1999. Independent acquisition and insertion into different chromosomal locations of the same pathogenicity island in Yersinia pestis and Yersinia pseudotuberculosis. Mol. Microbiol. 31:291-304.
  • Hare, J.M. and K.A. McDonough. 1999. Characterization of RecA independent high frequency Pigmentation (Pgm) mutations in Yersinia pestis. J. Bacteriol. 181 (16):4896-4904.
  • Rowland, B.R., A. Purkayastha, C. Monserrat, Y. Casart, H. Takiff and K.A. McDonough. 1999. Fluorescence-based detection of lacZ reporter gene expression in bacteria including Mycobacteria sp. FEMS Microbiol. Lett. 179:317-325.
  • McDonough, K. A. and J. M. Hare. 1997. Homology with a repeated DNA sequence from Yersinia pestis correlates with pesticin sensitivity in Yersinia pseudotuberculosis. J. Bacteriol. 179: 2081-2085.
  • McDonough, K. A. and Y. Kress.1995. Cytotoxicity for lung epithelial cells is a virulence-associated phenotype in Mycobacterium tuberculosis. Infect. Immun. 63(12): 4802-4811.

Contact Information

E-mail: kathleen.mcdonough@wadsworth.org