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Investigators and Program Directors

Randy Morse

Randall H. Morse

Research Scientist, Wadsworth Center, Molecular Genetics
Professor, School of Public Health, Biomedical Sciences

Ph.D., California Institute of Technology
Postdoctoral training, Columbia University and National Institutes of Health

E-mail: morse@wadsworth.org

<< Research Interests

Select Publications

  • MacQuarrie, K.L., A. P. Fong, R.H. Morse, and S.J. Tapscott.  2011.  Genome-wide transcription factor binding: beyond direct target regulation.  Trends Genet. 27: 141-148.
  • Ansari, S.A., M. Ganapathi, J.J. Benschop, F.C.P. Holstege, J.T. Wade, and R.H. Morse.  2011.  Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast.  EMBO J. (in press).
  • Tsui, K., S. Dubuis, M. Gebbia, R.H. Morse, N. Barkai, I. Tirosh, and C. Nislow.  2011. Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns.  Mol. Cell. Biol. (in press)
  • Morse, R.H.  2010.  Epigenetic marks identify functional elements.  Nature Genetics 42: 282-284.
  • Ganapathi, M., M.J. Palumbo, S. A. Ansari, Q. He, K. Tsui, C. Nislow, and R.H. Morse.  2011. Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast.  Nucl. Acids Res. 39: 2032-2044.
  • Ansari, S.A., Q. He, and R.H. Morse. 2009. Mediator complex association with constitutively transcribed genes in yeast. Proc. Natl. Acad. Sci. USA 39: 16734-16739.
  • He, Q., C. Yu and R.H. Morse. 2008. Dispersed mutations in histone H3 that affect transcriptional repression and chromatin structure of the CHA1 promoter in Saccharomyces cerevisiae. Euk. Cell 7: 1649-1660.
  • He, Q., L. Battistella, and R.H. Morse. 2008. Mediator requirement downstream of chromatin remodeling during transcriptional activation of CHA1 in yeast. J. Biol. Chem. 283: 5276-5286.
  • Yarragudi, A., L. W. Parfrey, and R. H. Morse. 2007. Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae. Nucleic Acids Res. 35: 193-202.
  • Sertil, O., A. Vemula, S.L. Salmon, R.H. Morse, and C.V. Lowry. 2007. Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast. Mol. Cell. Biol. 27: 2037-2047.
  • Lee, W., D. Tillo, N. Bray, R.H. Morse, R.W. Davis, T.R. Hughes, and C. Nislow. 2007. A high-resolution atlas of nucleosome occupancy in yeast. Nature Genetics 39: 1235-1244.
  • Morse, R.H. 2007. Transcription factor access to promoter elements. J. Cell. Biochem. 102: 560-570.
  • Yu, C., M.J. Palumbo, C.E. Lawrence, and R.H. Morse. 2006. Contribution of the histone H3 and H4 amino termini to Gcn4p- and Gcn5p-mediated transcription in yeast. J. Biol. Chem. 281: 9755-9764.
  • Sabet, N., S. Volo, C. Yu, J.P. Madigan, and R.H. Morse. 2004. Genome-wide analysis of the relationship between transcriptional regulation by Rpd3p and the histone H3 and H4 amino termini in budding yeast. Mol. Cell. Biol. 24: 8823-8833.
  • Yarragudi, A., T. Miyake, R. Li, and R.H. Morse. 2004. Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 24: 9152-9164.

Contact Information

Phone: 518-486-3116
Fax: 518-402-2299
E-mail: morse@wadsworth.org.