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Investigators and Program Directors

Randy Morse

Randall H. Morse

Research Scientist, Wadsworth Center, Developmental Genetics and Bioinformatics
Associate Professor, School of Public Health, Biomedical Sciences

Ph.D., California Institute of Technology
Postdoctoral training, Columbia University and National Institutes of Health

E-mail: morse@wadsworth.org

<< Research Interests

Select Publications

  • He, Q., L. Battistella, and R.H. Morse. 2008. Mediator requirement downstream of chromatin remodeling during transcriptional activation of CHA1 in yeast. J. Biol. Chem. (in press).
  • Yarragudi, A., L. W. Parfrey, and R. H. Morse. 2007. Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae. Nucleic Acids Res. 35: 193-202.
  • Sertil, O., A. Vemula, S.L. Salmon, R.H. Morse, and C.V. Lowry. 2007. Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast. Mol. Cell. Biol. 27: 2037-2047.
  • Lee, W., D. Tillo, N. Bray, R.H. Morse, R.W. Davis, T.R. Hughes, and C. Nislow. 2007. A high-resolution atlas of nucleosome occupancy in yeast. Nature Genetics 39: 1235-1244.
  • Morse, R.H. 2007. Transcription factor access to promoter elements. J. Cell. Biochem. 102: 560-570.
  • Yu, C., M.J. Palumbo, C.E. Lawrence, and R.H. Morse. 2006. Contribution of the histone H3 and H4 amino termini to Gcn4p- and Gcn5p-mediated transcription in yeast. J. Biol. Chem. 281: 9755-9764.
  • Sabet, N., S. Volo, C. Yu, J.P. Madigan, and R.H. Morse. 2004. Genome-wide analysis of the relationship between transcriptional regulation by Rpd3p and the histone H3 and H4 amino termini in budding yeast. Mol. Cell. Biol. 24: 8823-8833.
  • Yarragudi, A., T. Miyake, R. Li, and R.H. Morse. 2004. Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 24: 9152-9164.
  • Morse, R.H. 2003. Getting into chromatin: how do transcription factors get past the histones? Biochem. Cell Biol. 81: 101-112.
  • Sabet, N., F. Tong, J.P. Madigan, S. Volo, M.M. Smith, and R.H. Morse. 2003. Global and specific transcriptional repression by the histone H3 amino terminus in yeast. Proc. Natl. Acad. Sci. USA 100: 4084-4089.
  • Stafford, G.A. and R.H. Morse. 2001. GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast. Mol. Cell. Biol. 21: 4568-4578.
  • Yu, L., N. Sabet, A. Chambers, and R.H. Morse. 2001. The N-terminal and C-terminal domains of RAP1 are dispensable for chromatin opening and GCN4-mediated HIS4 activation in budding yeast. J. Biol. Chem. 276:33257-264.
  • Morse, R.H. 2000. RAP, RAP: Open up! New wrinkles for RAP1 in yeast. Trends Genet. 16: 51-53.
  • Ryan, M.P., G.A. Stafford, L. Yu, and R.H. Morse. 2000. Artificially recruited TATA-binding protein fails to remodel chromatin and does not activate three promoters that require chromatin remodeling. Mol. Cell. Biol. 20: 5847-5857.
  • Balasubramanian, B. and R.H. Morse. 1999. Binding of Gal4p and Bicoid to nucleosomal sites in yeast in the absence of replication. Mol. Cell. Biol. 19: 2977-2985.
  • Yu, L. and R.H. Morse. 1999. Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 5279-5288.
  • Morse, R.H. 1999. Analysis of DNA topology in yeast chromatin. Methods Mol. Biol., Humana Press (Totowa, NJ). 379-393.
  • Ryan, M.P., G.A. Stafford, L. Yu, K.B. Cummings, and R.H. Morse. 1999. Assays for nucleosome positioning in yeast. Methods Enzymol. 304, 376-399.

Contact Information

Phone: 518-486-3116
Fax: 518-402-2299
E-mail: morse@wadsworth.org.