Main Body
Investigators and Program Directors
Janice Pata
Research Scientist, Wadsworth Center,
Computational & Structural Biology
Assistant Professor, School of Public Health, Biomedical Sciences
Postdoctoral training, Yale University
Ph.D., University of Colorado at Boulder
B.S., California Institute of Technology
Email: jpata@wadsworth.org
Select Publications
- Pata JD, Stirtan WG, Goldstein SW, and Steitz TA (2004) Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. PNAS 101:10548-10553. PubMed
- Pata JD, King BR, Steitz TA (2002) Assembly, purification and crystallization of an active HIV-1 reverse transcriptase initiation complex. Nucleic Acids Research 30: 4855-4863. PubMed
- Zhou BL, Pata JD, Steitz TA (2001) Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain. Molecular Cell 8:427-437. PubMed
- Jäger J, Pata JD (2001) Viral RNA-directed polymerases. In: Structure-function Relationships of Human Pathogenic Viruses. E. Bogner and A. Holzenburg, Editors, Kluwer Academic Press, Plenum Publishers. Chapter 2, pages 53-84.
- Jäger J, Pata JD (1999) Getting a grip: polymerases and their substrate complexes. Current Opinion in Structural Biology 9:21-28. PubMed
- Pata JD, Schultz SC, Kirkegaard K (1995) Functional oligomerization of poliovirus RNA-dependent RNA polymerase. RNA 1:466-477. PubMed
Editorials Describing Our Work
- Research Focus. Trends in Pharmacological Sciences 26:4-7 (2005) "HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance" by J Ren and DK Stammers.
- Minireview. Cell 107:9-12 (2001) "Error-Prone DNA polymerases: novel structures and the benefits of infidelity" by EC Friedberg, PL Fischhaber, and C Kisker.
- Minireview. Structure 9:759-764 (2001) "DNA lesion bypass polymerases open up" by WA Beard and SH Wilson.
- News & Views. Nature Structural Biology 8:827-828 (2001) "The anatomy of infidelity" by T Ellenberger and LF Silvian.
Contact Information
Office: 518-402-2595
Lab: 518-402-4673
FAX: 518-402-4623
Email: jpata@wadsworth.org
Mailing address:
Wadsworth Center
New York State Department of Health
P.O. Box 509
Albany, NY 12201-0509
Street address:
Center for Medical Sciences
150 New Scotland Avenue
Albany, NY 12208
