Main Body
Investigators and Program Directors
Janice Pata
Research Scientist, Wadsworth Center, Molecular Diagnostics
Assistant Professor, School of Public Health, Biomedical Sciences
Postdoctoral training, Yale University
Ph.D., University of Colorado at Boulder
B.S., California Institute of Technology
Email: jpata@wadsworth.org
Select Publications
- Pata JD, Stirtan WG, Goldstein SW, and Steitz TA (2004) Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. PNAS 101:10548-10553. PubMed
- Pata JD, King BR, Steitz TA (2002) Assembly, purification and crystallization of an active HIV-1 reverse transcriptase initiation complex. Nucleic Acids Research 30: 4855-4863. PubMed
- Zhou BL, Pata JD, Steitz TA (2001) Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain. Molecular Cell 8:427-437. PubMed
- Jäger J, Pata JD (2001) Viral RNA-directed polymerases. In: Structure-function Relationships of Human Pathogenic Viruses. E. Bogner and A. Holzenburg, Editors, Kluwer Academic Press, Plenum Publishers. Chapter 2, pages 53-84.
- Jäger J, Pata JD (1999) Getting a grip: polymerases and their substrate complexes. Current Opinion in Structural Biology 9:21-28. PubMed
- Pata JD, Schultz SC, Kirkegaard K (1995) Functional oligomerization of poliovirus RNA-dependent RNA polymerase. RNA 1:466-477. PubMed
Editorials Describing Our Work
- Research Focus. Trends in Pharmacological Sciences 26:4-7 (2005) "HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance" by J Ren and DK Stammers.
- Minireview. Cell 107:9-12 (2001) "Error-Prone DNA polymerases: novel structures and the benefits of infidelity" by EC Friedberg, PL Fischhaber, and C Kisker.
- Minireview. Structure 9:759-764 (2001) "DNA lesion bypass polymerases open up" by WA Beard and SH Wilson.
- News & Views. Nature Structural Biology 8:827-828 (2001) "The anatomy of infidelity" by T Ellenberger and LF Silvian.
Contact Information
Office: 518-402-2595
Lab: 518-402-4673
FAX: 518-402-4623
Email: jpata@wadsworth.org
Mailing address:
Wadsworth Center
New York State Department of Health
P.O. Box 509
Albany, NY 12201-0509
Street address:
Center for Medical Sciences
150 New Scotland Avenue
Albany, NY 12208
