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Investigators and Program Directors

Haydeh Payami

Haydeh Payami

Research Scientist, Computational & Structural Biology
Computational & Structural Biology

Professor, School of Public Health, Biomedical Sciences
Lead Investigator, NeuroGenetics Research Consortium

Ph.D., University of California at Berkeley (1985)

E-mail: haydeh.payami@health.ny.gov

Research Interests

The long term goal of our research is to reduce the burden of common human disorders. The primary focus of our lab is neurodegenerative disorders, including Parkinson's disease and dementia (e.g., Alzheimer's disease), and the means to promote healthy brain aging. Our targeted strategy is personalized medicine, whereby prevention and treatment would be personalized based on individualís genetic makeup to achieve maximum benefit. Our research takes a whole-genome, and gene-environment interaction approach. Currently, the following studies are ongoing in the lab:

  1. Studies aimed at prevention are carried out through (a) targeted and genomewide association studies to identify genes that affect risk or age at onset of symptoms; (b) identification and validation of protective factors that could be used for intervention; and (c) gene-environment interaction studies, to delineate genetic backgrounds that would be most responsive to intervention.
  2. Studies aimed at slowing disease progression include (a) pharmacogenomics studies to identify determinants of response to treatment, and (b) clinical and genetic studies to predict prognosis and treat patients early to avoid disease complications and disability.
  3. Basic studies aimed at better understanding the links between Alzheimer's and Parkinson's disease and identification of pathways that are common to neurodegenerative disorders.
  4. Mathematical and statistical modeling and development of novel analytical methods for genetic analysis of complex disorders.
>> Select Publications

Contact Information

E-mail: haydeh.payami@health.ny.gov.