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Investigators and Program Directors

Brian Pentecost

Research Scientist, Wadsworth Center, Human Toxicology and Molecular Epidemiology
Assistant Professor, School of Public Health, Environmental Health Sciences

Ph.D., University of London
Postdoctoral training, University of Calgary

E-mail: brian.pentecost@wadsworth.org

<< Research Interests

Select Publications

  • Pentecost, B.T., Bradley L.M., Gierthy J.F., Ding, Y., and Fasco, M.J. (2005) Gene Regulation in an MCF-7 Cell Line that Naturally Expresses an Estrogen Receptor Unable to Directly Bind DNA Mol. Cell Endocrinol. In press.
  • Pentecost, B.T., R. Song, M. Luo, J.A. DePasquale, and M.J. Fasco. (2005) Upstream regions of the estrogen receptor alpha proximal promoter transcript regulate ER protein expression through a translation mechanisms. Mol. Cell Endocrinol. 229, 83-94.
  • Gozgit, J.M., K.N. Nestor, M.J. Fasco, B.T. Pentecost, and K.F. Arcaro, (2004) Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen responsive genes and on a transfected estrogen responsive reporter in MCF-7 cells. Toxicol. App. Pharma. 196, 58-67.
  • Spink, D.C., B.H. Katz, M.M. Hussain, B.T. Pentecost, Z. Cao and B.C. Spink (2003) Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells. Carcinogenesis 24, 1941-50.
  • Han, W., B.T. Pentecost, and S. Spivack (2003) Functional evaluation of novel SNPs and haplotypes in the promoter regions of CYP1B1 and CYP1A1. Mol. Carcinogen. 37, 158-69.
  • Fasco, M.J., A. Amin, B.T. Pentecost, Y. Yang, J.F. Gierthy (2003) Changes in estrogen receptor-related phenotypic changes in MCF-7 cells during prolonged exposure to tamoxifen. Mol. Cell. Endocrinol. 206, 33-47.
  • Spink, B.C., S. Pang, B.T. Pentecost, and D.C. Spink (2002) Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychorinated biphenyls. Toxicol. In-vitro 16, 695-704.
  • Pentecost, B.T. Expression and estrogen regulation of the novel HEM45 mRNA in human tumor lines and in the rat uterus. J Steroid Biochem & Mol Bio. In press.
  • Spink, D.C., Spink, B.C., Cao, J.Q., DePasquale, J.A., Pentecost, B.T., Fasco, M.J., Li, Y., and Sutter, T.R. (1998) Differential Expression of CYP1A1 and CYP1B1 in Human Breast Epithelial Cells and Breast Tumor Cells. Carcinogenesis. In Press.
  • Pentecost, B.T., Newbold, R.R., Teng, C.T. and McLachlan, J.A. (1998) Prenatal exposure of male mice to diethylstilbestrol alters the expression of the lactotransferrin gene in seminal vesicles. Molecular Endocrinology 2:1243-1248.
  • Gierthy, J.F., Spink, B.C., Figge, H.L., Pentecost, B.T. and Spink, D.C. (1996) Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin, 12-O-Tetradecanoylphorbol-13-Acetate and 17b-Estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J. Cell Biochem. 60:173-184.
  • Quirk, S.M., Pentecost, B.T., Mackman, N., Loskutoff, D.J., Hartzell, S. and Henrikson, K.P. (1995) Mechanism for the regulation of uterine tissue factor by estrogen. Endocrine 3:177-184.
  • Wu-Peng, X.S., Pugliese, T.E., Dickerman, H.W. and Pentecost, B.T. (1992) Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene. Molecular Endocrinology 6:231-240.

Contact Information

E-mail: brian.pentecost@wadsworth.org.