Investigators and Program Directors
Richard F. Seegal
Research Scientist, Wadsworth Center, Molecular Toxicology
Professor, School of Public Health, Biomedical Sciences and Environmental Health Sciences
Ph.D., Physiological Psychology, University of Georgia
(1972)
Post Doctoral Training: University of Connecticut, BioBehavioral
Sciences (1972-1974)
E-mail: seegal@wadsworth.org
Research Interests
We use in vitro and organotypic culture systems, as well as in vivo techniques, to better understand the neurochemical and neuroimmunological mechanisms responsible for alterations in nervous system function induced by exposure to occupational and environmental neurotoxicants, including polychlorinated biphenyls (PCBs), pesticides and methylmercury. Major interests include study of the role that dopamine, an important central neurotransmitter, plays in affecting behavior, neuroendocrine function and intra and extra-cellular signaling. Because PCBs reduce brain dopamine concentrations, alter immune function and induce oxidative stress (factors associated with chronic neurodegenerative diseases) we are also investigating the role PCBs and other neurotoxicants play in inducing Parkinson's Disease using both laboratory and epidemiologic approaches.
Contact Information
E-mail: seegal@wadsworth.org