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Investigators and Program Directors

Richard F. Seegal

Richard F. Seegal

Research Scientist, Wadsworth Center, Molecular Toxicology
Professor, School of Public Health, Biomedical Sciences and Environmental Health Sciences

Ph.D., Physiological Psychology, University of Georgia (1972)
Post Doctoral Training: University of Connecticut, BioBehavioral Sciences (1972-1974)

E-mail: seegal@wadsworth.org

<< Research Interests

Select Publications

  • Dreiem, A. and Seegal, R.F. Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent. Neurotoxicology, (in press).
  • Lyng, G.D., Synder-Keller, A. and Seegal, R.F. Polychlorinated biphenyl-induced neurotoxicity in organotypic co-cultures of developing rat ventral mesencephalon and striatum. Toxicol. Sci., 97, 128-139, 2007.
  • Lyng, G.D., Synder-Keller, A. and Seegal, R.F. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain Res., 1133, 1-9, 2007.
  • Dreiem, A., Gertz, C.C. and Seegal, R.F. The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent. Toxicol. Sci., 87, 156-162, 2005.
  • Roegge, C.S., Widholm, J.J., Engeseth, N.J., Wang, X., Brosch, K.O., Seegal, R.F. and Schantz, S.L. Delayed spatial alternation impairments in adult rats following dietary n - 6 deficiency during development. Neurotoxicol. Teratol., 27, 485-495, 2005.
  • Seegal, R.F., Brosch, K.O. and Okoniewski, R.J. Coplanar PCB congeners increase uterine wet weight and frontal cortical dopamine in the developing rat: Implications for developmental neurotoxicity. Toxicol. Sci., 86, 125-131, 2005.
  • Wilholm, J.J.,Villareal S., Seegal, R.F. and Schantz, S.L. Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicol. Sci., 82, 577-589, 2004.
  • Kim, D., Seegal, R.F., Lawrence, D.A. Splenic norepinephrine and serum corticosterone level fluctuations associated with bacteria-induced stress. Neuroimmunomodulation, 11, 323-331, 2004.
  • Bemis, J. C. and R.F. Seegal (2004) PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicol. Sci., 80, 288-295, 2004.
  • Seegal, R.F. Effects of PCBs and Dioxins on Intra- and Extracellular Signaling Mechanisms. In: Dioxins and Health, Second Edition, pp. 433-456, John Wiley & Sons, New York, 2003.
  • Seegal, R.F. Neurological effects of polychlorinated biphenyls - Does occupational exposure alter dopamine mediated function? In: Parkinson's Disease: The Life Cycle of the Dopamine Neuron. Ann. NY Acad. Sci., 991, 322-325, 2003.
  • Wilholm, J.J., Seo, B.-W., Strupp, B.J., Seegal, R.F. and Schantz, S.L. Effects of perinatal exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) on spatial and visual reversal learning in rats. Neurotoxicol. Teratol., 25, 459-471, 2003.
  • Filipov, N.M., Cao, L., Seegal, R.F. and Lawrence, D.A. Compromised peripheral immunity of mice injected intrastriatally with six-hydroxydopamine. J. Neuroimmunol., 132, 129-139, 2002.
  • Seegal, R.F., Okoniewski, R.J., Brosch, K.O. and Bemis, J.C. Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum-an in vivo microdialysis study. Environ. Health Perspect., 110, 1113-1117, 2002.
  • Seegal, R.F. and Bowers, W.J. Consequences and mechanisms of action of fish-borne toxicants: What we don't know and why. Environ. Toxicol. Pharmacol., 12, 63-68, 2002.
  • Kreiling, J.A., Jessen-Eller, K., Milller, J., Seegal, R.F. and Reinisch, C.L. Early development of the serotonergic and dopaminergic nervous system in Spisula solidissima (surf clam) larvae. Comp. Biochem. Physiol. [A], 130, 341-351, 2001.
  • Seegal, R.F. Neurochemical Effects of Polychlorinated Biphenyls: A Selective Review of the Current State of Knowledge. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects, pp. 241-255, University Press of Kentucky, Lexington, 2001.
  • Widholm, J.J., Clarkson, G.B., Strupp, B.J., Crofton, K.M., Seegal, R.F. and Schantz, S.L. Spatial reversal learning in Aroclor 1254 or dioxin-exposed rats: Sex-specific deficits in associative ability and inhibitory control in Aroclor 1254-exposed rats. Toxicol. Appl. Pharmacol., 174, 188-198, 2001.
  • Bemis, J.C. and Seegal, R.F. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. Neurotoxicology, 21, 1123-1134, 2000.
  • Seegal, R.F. The neurological consequences of developmental exposure to PCBs. Toxicol. Sci., 57, 1-3, 2000.
  • Bemis, J.C. and Seegal, R.F. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine in vitro. Environ. Health Perspect., 107, 879-885, 1999.
  • Kim, D., Carlson, J.N., Seegal, R.F. and Lawrence, D.A. Differential immune responses in mice with left- and right-turning preference. J. Neuroimmunol., 93, 164-171, 1999.
  • Seegal, R.F. Are PCBs the major neurotoxicant in Great Lakes salmon? Environ. Res. Section A, 80, S38-S45, 1999.

Contact Information

E-mail: seegal@wadsworth.org