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Investigators and Program Directors

David Spink

David C. Spink

Research Scientist, Wadsworth Center, Human Toxicology and Molecular Epidemiology
Associate Professor, School of Public Health, Environmental Health Sciences

Ph.D., University of Maryland (1983)

E-mail:spink@wadsworth.org

<< Research Interests

Select Publications

  • Xu, L., and D.C. Spink (2007) 1,2-Dimethylimidazole-4-sulfonyl chloride, a novel derivatization reagent for the analysis of phenolic compounds by liquid chromatography electrospray tandem mass spectrometry: Application to 1-hydroxypyrene in human urine. Journal of Chromatography B -Analytical Technologies in the Biomedical and Life Sciences (in press).
  • Spink, B.C., Cole, R.W., Katz, B.H., Gierthy, J.F., Bradley, L.M., and D.C. Spink (2006) Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture. Cell Biology International 30, 227-238.
  • Oenga, G.N, Spink, D.C., and D.O. Carpenter (2004) TCDD and PCBs inhibit breast cancer cell proliferation in vitro. Toxicology In Vitro 18, 811-819.
  • Spink, B.C., M.M. Hussain, B.H. Katz, L. Eisele, and D.C. Spink (2003) Transient Induction of Cytochromes P450 1A1 and 1B1 in MCF-7 Human Breast Cancer Cells by Indirubin. Biochemical Pharmacology 66, 2313-2321.
  • Spink, D. C., B.H. Katz, Z. Cao, B.T. Pentecost, M.M. Hussain, and B.C. Spink (2003) Estrogen Regulates Ah Responsiveness in MCF-7 Breast Cancer Cells. Carcinogenesis 24, 1941-1950.
  • Spink, B.C., S. Pang, B.T. Pentecost, and D.C. Spink (2002) Induction of Cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho -substituted polychlorinated biphenyls. Toxicology In Vitro 16, 695-704.
  • Zhu, B. T., M.X. Cai, D.C. Spink, M.M. Hussain, G.H. Lambert, A. Ranzini, A. Cornfield, P.E. Thomas, and A.H. Conney (2002) Stimulatory effect of cigarette smoking on the 15alpha hydroxylation of 17beta-estradiol by human term placenta. Clinical Pharmacology and Therapeutics 71, 311-324.
  • Spink, D. C., B.H. Katz, M.M. Hussain, S.J. Wu, N. Liu, B.C. Spink, R. Pause, and L.S. Kaminsky, (2002) Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metabolism and Disposposition 30, 262-269.
  • Spink, D.C., Zhang, F, Hussain, M. M., Katz, B. H., Liu, X., Hilker, D. R., and Bolton, J. L. (2001) Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chemical Research in Toxicology 14, 572-581.
  • Spink, D. C., Spink, B. C., Zhuo, X., Hussain, M. M., Gierthy, J. F., and Ding, X. (2000) NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. Journal of Steroid Biochemistry and Molecular Biology 74, 11-18.
  • Spink, B. C., Katz, B. H., Hussain, M. M., Pang, S., Connor, S. P., Aldous, K. M., Gierthy, J. F., and Spink, D. C. (2000) SULT1A1 catalyzes 2-methoxyestradiol sulfation in MCF-7 breast cancer cells. Carcinogenesis 21, 1947-1957.
  • Pang, S., Cao, J. Q., Katz, B. H., Hayes, C. L., Sutter, T. R., and Spink, D. C. (1999) Inductive and inhibitory effects of non-ortho-substituted polychlorinated biphenyls on estrogen metabolism and cytochromes P450 1A1 and 1B1. Biochemical Pharmacology 58, 29-38.

Contact Information

E-mail:spink@wadsworth.org.