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Investigators and Program Directors

Victoria Derbyshire

Victoria Derbyshire

Research Scientist, Wadsworth Center, Developmental Genetics and Bioinformatics
Assistant Professor, Biomedical Sciences, School of Public Health

Ph.D., Yale University (1990)
Postdoctoral training, Yale University, Wadsworth Center

E-mail: vicky.derbyshire@wadsworth.org.

<< Research Interests

Select Publications

  • Wu, W., Wood, D.W., Belfort, G., Derbyshire, V. and Belfort, M. Intein-mediated purification of cytotoxic endonuclease I-TevI by insertional inactivation and pH-controllable splicing. Nucleic Acids Research (2002) 30, 4864-4871.
  • Kowalski, J.C. and Derbyshire, V. Characterization of homing endonucleases. Methods (2002) 28, 365-373.
  • Van Roey, P., Meehan, L., Kowalski, J.C., Belfort, M. and Derbyshire, V. Catalytic structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI. Nature Structural Biology (2002) 9, 806-811.
  • Dean, A.B., Stanger, M.J., Dansereau, J.T., Van Roey, P., Derbyshire, V., and Belfort, M. Zinc finger as distance determinant in the flexible linker of intron endonuclease I-TevI. Proc Natl Acad Sci USA (2002) 99, 8554-8561.
  • Belfort, M., Derbyshire, V., Cousineau, B. and Lambowitz, A. Mobile introns: pathways and proteins. In Mobile DNA II. (2001) N. Craig, R. Craigie, M. Gellert and A. Lambowitz, eds. ASM Press.
  • VanRoey, P., Waddling, C.A., Fox, K.M., Belfort, M., and Derbyshire, V. (2001) Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate. EMBO J. 2001 20, 3631-3637.
  • McCue, L.Thompson, W., Carmack, C.S., Ryan, M.P., Liu, J.S., Derbyshire, V. and Lawrence, C.E. (2001) Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes. Nucleic Acids Res. 29, 774-782.
  • Wood, D., Wu, W., Belfort, G., Derbyshire, V. and Belfort, M. (1999) Protein engineering of inteins: genetic system yields self-cleaving element for bioseparations. Nature Biotechnology 17, 889-892.
  • Kowalski, J.C., Belfort, M., Stapleton, M.A., Holpert, M., Dansereau, J.T., Pietrokovski, S., Baxter, S. and Derbyshire, V. (1999) Configuration of the catalytic GIY-YIG domain of intron endonuclease I-TevI: coincidence of computational and molecular findings. Nucleic Acids Res. 27, 2115-2125.
  • Derbyshire, V. and Belfort, M. (1998) Lightning strikes twice: intron-intein coincidence. Proc. Natl. Acad.Sci. USA 95, 1356-1357.
  • Derbyshire, V., Wood, D.W., Wu, W., Dansereau, J.T., Dalgaard, J.Z. and Belfort, M. (1997) Genetic definition of a protein-splicing domain: functional mini-inteins support structure predictions and a model for intein evolution. Proc. Natl. Acad. Sci. USA 94, 11466-11471.
  • Derbyshire, V., Kowalski, J.C., Dansereau, J.T., Hauer, C.R. and Belfort, M. (1997) Two-domain structure of the td intron-encoded endonuclease I-TevI correlates with the two-domain configuration of the homing site. J. Mol. Biol. 265, 494-506.

Contact Information

E-mail: vicky.derbyshire@wadsworth.org