Investigators and Program Directors

Select Publications

• Zhu Y, D’Agostino J, and *Zhang Q-Y. Role of Intestinal Cytochrome P450 in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse. Drug Metab. Dispos. 39, 939-943, 2011
• Fang, C., *Zhang, Q.-Y.: The role of small-intestinal P450 enzymes in protection against systemic exposure of orally administered benzo(α)pyrene. J. Pharmacol. Expt. Ther. 334,156-63, 2010.
• Wei, Y., Zhou, X., Fang, C., Li, L., Kluetzman, K., Yang, W., Zhang, Q-Y., and Ding, X.: Generation of a mouse model with a reversible hypomorphic NADPH-cytochrome P450 reductase (Cpr) gene: utility for tissue-specific rescue of CPR expression, and insights from a resultant extrahepatic-Cpr-low mouse. J. Pharmacol. Expt. Ther. 334(1):69-77, 2010
• Zhang, Q.-Y., Fang, C., Dunbar, D., Zhang, J., Kaminsky, L.S., and Ding, X. An intestinal epithelium-specific cytochrome P450 reductase-knockout mouse model: direct evidence for a role of intestinal cytochromes P450 in first-pass clearance of oral nifedipine. Drug Metab. Dispos., 37 , 651-657 (2009). NIHMSID #82117
• Zhang, Q.-Y., Kaminsky, L. S., Dunbar, D., and Ding, X.: Role of Small Intestinal Cytochrome P450 in the Bioavailability of Oral Nifedipine. Drug Metab. Dispos. 35 , 1617–1623 (2007).
• Zhang, X., D’Agostino, J., Wu, H., Zhang, Q.-Y., von Weymarn, L., Murphy, S. E., and Ding, X.: CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Expt. Ther. 323 , 570-578 ( 2007).
• Zhang, Q.-Y., Gu, J., Su, T., Cui, H., Zhang, X., D'Agostino, J., Zhuo, X., Yang, W., Swiatek, P., and Ding, X.: Generation and Characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochem. Biophys. Res. Commun. 338 , 318-324 (2005).
• Zhang, X., Zhang, Q.-Y., Liu, D., Su, T., Weng, Y., Ling, G., Chen, Y., Gu, J., Schilling, B., and Ding, X. Expression of cytochrome P450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metab. Dispos. 33 , 1423-1428 (2005).
• Von Weymarn, L. B. Zhang Q.-Y., Ding X., and Hollenberg P. F.: Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis, 26 , 621-629 (2005).
• Zhang Q-Y, Dunbar D, and Kaminsky LS. Characterization of mouse small intestinal cytochrome P450 expression. Drug Metab Dispos 31 :1346-1351 (2003).
• Kaminsky LS, and Zhang Q-Y. The small intestine as a xenobiotic-metabolizing organ. Drug Metab Dispos 31 :1520-1525 (2003).
• Su T, Zhang Q-Y, Zhang J, and Ding X. Expression of Rat CYP2A3 Gene in Transgenic Mice. Drug Metab Dispos 30 :548-552 (2002).
• Liu N, Zhang Q-Y, Vakharia D, Dunbar, D, and Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2. Arch Biochem Biophys 389 :130-134 (2001).
• Obach SR, Zhang Q-Y, Dunbar D, and Kaminsky LS: Metabolic characterization of the major human small intestinal cytochrome P450s. Drug Metab Dispos 29:347-352 (2001).
• Zhang Q-Y, Dunbar D, and Kaminsky L. Human cytochrome P-450 metabolism of retinals to retinoic acids. Drug Metab Dispos 28:292-297 (2000).

Contact Information

E-mail: zhangq@wadsworth.org

Key words: pharmacogenetics, drug metabolism, cytochrome P450, small intestine, adverse drug reaction, chemical toxicity