Main Body
Investigators and Program Directors
Qing-Yu Zhang
Research Scientist, Wadsworth Center, Human Toxicology and Molecular Epidemiology
Adjunct Assistant Professor, School of Public Health, Environmental Health Sciences
Ph.D., Biological Chemistry, University of Michigan (1989)
Postdoctoral training: University of Michigan
E-mail: zhangq@wadsworth.org
Select Publications
- Zhang, Q.-Y., Gu, J., Su, T., Cui, H., Zhang, X., D'Agostino, J., Zhuo, X., Yang, W., Swiatek, P., and Ding, X.: Generation and Characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochem. Biophys. Res. Commun. 338, 318-324 (2005).
- Zhang, X., Zhang, Q.-Y., Liu, D., Su, T., Weng, Y., Ling, G., Chen, Y., Gu, J., Schilling, B., and Ding, X. Expression of cytochrome P450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metab. Dispos. 33, 1423-1428 (2005).
- Von Weymarn, L. B. Zhang Q.-Y., Ding X., and Hollenberg P. F.: Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis, 26, 621-629 (2005).
- Zhang Q-Y, Dunbar D, and Kaminsky LS. Characterization of mouse small intestinal cytochrome P450 expression. Drug Metab Dispos 31:1346-1351 (2003).
- Gu J, Weng Y, Zhang Q-Y, Cui H, Behr M, Wu L, Yang W, Zhang L, and Ding X. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278:25895-25901 (2003).
- Kaminsky LS, and Zhang Q-Y. The small intestine as a xenobiotic-metabolizing organ. Drug Metab Dispos 31:1520-1525 (2003).
- Su T, Zhang Q-Y, Zhang J, and Ding X. Expression of Rat CYP2A3 Gene in Transgenic Mice. Drug Metab Dispos 30:548-552 (2002).
- Liu N, Zhang Q-Y, Vakharia D, Dunbar, D, and Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2. Arch Biochem Biophys 389:130-134 (2001).
- Obach SR, Zhang Q-Y, Dunbar D, and Kaminsky LS: Metabolic characterization of the major human small intestinal cytochrome P450s. Drug Metab Dispos 29:347-352 (2001).
- Zhang Q-Y, Dunbar D, and Kaminsky L. Human cytochrome P-450 metabolism of retinals to retinoic acids. Drug Metab Dispos 28:292-297 (2000).
- Zhang Q-Y, Dunbar D, Ostrowska A, Zeisloft S, Yang J, Kaminsky LS. Characterization of human small intestinal cytochromes P450. Drug Metab Dispos 27:804-809 (1999).
- Zhang Q-Y, Ding X, Dunbar D, Cao L, and Kaminsky LS. Induction of rat small intestinal cytochrome P450 2J4. Drug Metab Dispos 27:1123-1127 (1999).
Contact Information
E-mail: zhangq@wadsworth.org
Key words: pharmacogenetics, drug metabolism, cytochrome P450, small intestine, adverse drug reaction, chemical toxicity