Resource for the Visualization of Biological Complexity (RVBC)
Mission
The mission and long-term goal of the RVBC is twofold: (1) to develop tools for visualization of biological systems in their entirety, in close to native conditions, and (2) to make this technology, when firmly established and tested, available to the scientific community. We are making use of advanced methods of three-dimensional imaging with the electron microscope and computation to look at different levels of biological architecture, and aim to integrate the knowledge gained from these experiments with existing data towards a comprehensive understanding of biological systems - their structure and dynamics. While single-particle reconstructions methods are used to study macromolecular interactions in isolated, well-characterized systems, electron tomography provides a detailed picture of the cell in its entirety.
Executive Committee
Dr. Carmen Mannella, PI
carmen@wadsworth.org
518-474-2462
Dr. Conly Rieder, Co-PI
rieder@wadsworth.org
518-474-6774
Dr. Rajendra Agrawal
agrawal@wadsworth.org
518-486-5797
Dr. Joachim Frank
jf2192@columbia.edu
212-305-9510
Mr.Michael Marko
marko@wadsworth.org
518-474-7049
Dr.Bruce McEwen
bruce@wadsworth.org
518-486-9102
Dr.Terence Wagenknecht
terry@wadsworth.org
518-474-2450
Scientific Staff
Mr. David Barnard - HVEM facility, instrument development, time-resolved cryo-EM
Dr. William Baxter - SPIDER development, SPIRE (reconstruction engine)
Ms. Chyongere Hsieh - Cryo-tomography, cryo-preparation, frozen-hydrated sections
Dr. ArDean Leith - SPIDER and WEB development, algorithm development
Dr. Tapu Shaikh - Single-particle EM: algorithm development, time-resolved cryo-EM
Administrative Assistant, mailing address
Ms. Diane Ray
Resource for Visualization of Biological Complexity
Wadsworth Center
P.O. Box 509
Albany, NY 12201-0509
Tel: 518-402-579
Fax: 518-408-1815
RVBC facility use
Individuals interested in using the facility may contact Dr. Carmen Mannella, Director of the RVBC . The application form is available as an (Adobe PDF file size: 15K) and should be emailed to the Administrative Assistant for review by the Executive Committee.