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Stewart Sell, M.D.
- Cancer: To determine the role of tissue determined stem cells in the generation of liver cancer induced by aflatoxin in mice.
- Cancer: To isolate, culture and characterize breast cancer stem cells from transgenic mice.
- Cancer: To determine if proliferation of breast cancer stem cells can be specifically blocked by small molecular inhibitors or inhibitory RNA. This is a critical step to preventing re-growth of breast cancer after chemotherapy or radiation therapy.
- Aging: To test the hypothesis that high expression of a naturally occurring short isoform of p53 (Δ40p53) by hematopoietic stem cells (HSCs) or bone marrow stroma (BMS) leads to increased asymmetric division of HSCs and an accelerated loss of HSCs with aging.
- Alcohol and Liver Injury: To determine the possible interaction of alcohol induced injury and aflatoxin exposure in production of liver injury and liver cancer using a specific knockout mouse (glutathionine-S-transferase A3) that is susceptible to aflatoxin injury (normal mice are very resistant).
- Tuberous Sclerosis: To determine the cell of origin of the lesions of Tuberous Sclerosis.
Honors and Awards
- Listed in Current Contents as one of 1,000 most quoted scientists, 1981
- Paper listed as "Citation Classic" by Current Contents, 1984
- Philip S. Hench Distinguished Alumnus Award, U. Pittsburgh School of Medicine, 1988
- Distinguished Scientist Award, International Academy of Tumor Marker Oncology, 1998
- Gary J. Miller Memorial Award for excellence in teaching, AACR, 2002
- Rudolph L. K. Virchow Award, LeadershipMedica, ITALY, 2005
- Legacy Laureate, University of Pittsburgh (Highest Honor for Alumni), 2005.
- Paper cited as Scientific Landmark in Cancer Research by the American Association for Cancer Research, 2007
Guest IC, Sell S.
Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT).
Sell S, Guest I, McKinstry KK, Strutt TM, Kohlmeier JE, Brincks E, Tighe M, Blackman MA, Woodland DL, Dutton RW, Swain SL.
Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.
Sell S, Pierce GB.
Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.
Sell S, Gell PG.
Studies on Rabbit Lymphocytes In Vitro. I. Stimulation of Blast Transformation with an Antiallotype Serum.
J Exp Med.
Ma J, Lanza DG, Guest I, Uk-Lim C, Glinskii A, Glinsky G, Sell S.
Characterization of mammary cancer stem cells in the MMTV-PyMT mouse model.