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Pushing the Boundaries of Cryo-Electron MicroscopyWe’ve all left a water bottle in the freezer overnight only to find it bulging the next morning. That’s what water does when it freezes. It expands, right?Not always.Did you know, it is possible to freeze water without it expanding?Water expands when it freezes because ice crystals form. Since ice crystals damage cell structure, two freezing methods that don’t result in crystal formation are used in cryo-electron microscopy:

FERN was formed in response to the anthrax attacks that followed 9/11. It was then and is now a network of local, state and federal laboratories which contributes testing capability and capacity, relieving the burden to other agencies that also test food samples. Over time, the mission of FERN has broadened to include food safety and public health emergency and outbreak testing.Because food could be contaminated, intentionally or not, by many types of agents, there are FERN microbiology, chemical, and radiation laboratories. Wadsworth Center is home to all three.

Beginning on January 9, 2017, the New York State Department of Health Rabies Laboratory will no longer routinely staff the laboratory on weekends or holidays unless the Bureau of Communicable Disease Control (BCDC) has approved a request for emergency testing.Requests for emergency testing must be received by 3:00PM on Fridays (or the last business day before a holiday) to ensure Rabies Laboratory staff are aware of an incoming weekend/holiday specimen.

Former Arbovirus Laboratory Director and ProMED Co-founder Jack Woodall January 13, 1935 – October 24, 2016 Dr. Woodall lived in many countries and worked in even more throughout his lifetime. What follows is by no means a complete list:

For bacteria, sharing genetic information can be critical to survival. It can also make them fitter, better pathogens, and more able to evade the immune system and resist antibiotics. One way bacteria share their genetic information is by a process called conjugation, in which DNA is transferred from a donor to a recipient strain. Incorporation of the donor genetic information into the recipient chromosome can confer novel functions to the resulting transconjugant cells.

“This is special. This is really special,” says Nellie Dumas, Associate Director of the Bacteriology Laboratory in regard to Wadsworth Center’s Clinical Laboratory Information Management System (CLIMS), an electronic way of tracking sample information from submission to reporting.  Why is CLIMS so special? Is it because of the impressive numbers: approximately 3,100 users outside of Wadsworth Center, 3,000 facilities, 1.8 million specimens and 16 million results to date?

Wadsworth Center Scientists, including graduates of the Masters of Science in Laboratory Sciences Program, laboratorians, research scientists, principal investigators, and the current and former Directors took part in the conference recently held at the Albany College of Pharmacy and Health Sciences.

Recently, the 10th annual Laboratory of Clinical Microbiology (LCM) Poster Day was held at the David Axelrod Institute. LCM Research Seminars take place monthly, September through June. This annual poster session kicks off the 31st year of seminars. Wadsworth Center staff from multiple sites attended. Highlights of eleven posters, all previously presented at scientific meetings locally and nationwide, follow.

Failing to work with a microorganism at the correct Biosafety Level (BSL) in the laboratory has the potential to place people at risk of accidental exposure to infectious agents, so it is not a surprise that the June 5, 2014 incident at the Centers for Disease Control and Prevention (CDC) was such a high profile one.

Norovirus is a primary cause of acute gastroenteritis and foodborne disease in the United States where, according to the CDC, it is responsible for "19 - 21 million cases of acute gastroenteritis, 1.7 - 1.9 million outpatient visits and 400,000 emergency room visits per year. It also contributes to between 56,000 - 71,000 hospitalizations and 570 - 800 deaths per year, mostly among young children and the elderly." 

Based on continuous quality improvement by retrospectively looking at levels of analytes detected in infants referred for screened conditions who had the disease and those who did not, the Newborn Screening Program is making the following modifications: 1. Changing the reference range values for free carnitine (C0) and propionylcarnitine (C3) used for the evaluation of carnitine uptake disorder (CUD) 2. Discontinuing the use of methylmalonylcarnitine (C4DC) as a diagnostic marker for the evaluation of propionic acidemia and methylmalonic acidemia (PA/MMA)

New York’s Wadsworth Center Laboratory was one of five state public health laboratories selected by the Association of Public Health Laboratories as a pilot site for Mycobacterium tuberculosis complex (MTBC) Whole Genome Sequencing (WGS). The Wadsworth Center Bacteriology and Mycobacteriology Laboratories will sequence all strains from patients in New York State, including New York City, with this highly comprehensive testing approach that assesses all 4.4 million bases of the MTBC genome.

NYSDOH Lab Part of a Consortium to Investigate Effects of Environmental Factors During Early Development on the Health of Children and Adolescents ALBANY, N.Y. (September 23, 2016) - New York State Department of Health today announced that its renowned laboratory, Wadsworth Center, has been awarded $1.2 million from the National Institutes of Health (NIH) as part of the launch of a seven-year initiative called Environmental Influences on Child Health Outcomes (ECHO).

In 2014 the Centers for Disease Control and Prevention (CDC) and the Association of Public Health Laboratories (APHL) made the first changes to the recommended HIV testing algorithm in a quarter of a century. According to the new scheme, a small portion of all specimens will require a final test not performed by most laboratories-a nucleic acid test or NAT.

White-nose syndrome, first identified in the US in New York during the winter of 2006-2007 has killed millions of North American bats, and as of May 2016, has been confirmed in 29 states and 5 Canadian territories.Threatened and endangered bat species alike are affected. In some locations, the little brown bat population is 10% of what it was before white-nose syndrome.

Considering that the number of mumps cases per year has decreased by more than 99% since the introduction of vaccines against the disease, it is relatively rare these days to hear about a mumps outbreak. But that is just what has happened this summer as more than 45 in the Nassau County city of Long Beach became ill. What makes this outbreak so surprising is that this population has a high vaccination rate.

In Albany, as in many places, August is the time when college students start back to school. But this August 17th at the Wadsworth Center, the Master of Science in Laboratory Sciences students are just finishing.As the only master’s degree program sponsored by a public health laboratory, students are immersed in the business of public health, from the policy, regulations and standards, to the research that goes into developing diagnostic tests and the testing of clinical and environmental specimens.

On August 3, 2016 New York State Commissioner of Health Dr. Howard A. Zucker announced the Wadsworth Center has been awarded $1.8 million to serve as one of seven labs in the nation designated as an Antimicrobial Resistance (AR) Regional Laboratory. These laboratories, strategically placed across the country, will have specialized capabilities allowing rapid detection and identification of emerging antibiotic resistant threats.

Clarification is provided for the allowable testing in the physician office laboratory, where the technical component/professional component (TC/PC) split affects pathology specimens. 

WASHINGTON – The Centers for Disease Control and Prevention designated Albany's Wadsworth Laboratory as one of seven regional labs to tackle the growing threat of antibiotic resistance.  Read More at The Times Union.