Research in the Ghosh laboratory focuses on the mechanisms of antibiotic resistance in M. abscessus, which is a rapidly emerging nontuberculous mycobacteria (NTM) in patients with Cystic Fibrosis and underlying lung damage.

Specific projects include:

1. Systems level understanding of changes that accompany exposure of M. abscessus to antibiotics.
2. Identification of effectors that confer unique profiles of drug resistance.
3. Screening of small molecule libraries for inhibitors of identified targets.
4. Study the role of biofilm formation on antibiotic resistance of M. abscessus.

We use a combination of bacterial genetics, biochemistry and high throughput genomic analysis to decipher mechanisms of drug resistance.

Postdoctoral Position Available [2]