Research in the Morse laboratory has focused on basic mechanisms of eukaryotic gene regulation, using the yeast Saccharomyces cerevisiae as a tractable model for studies on the role of chromatin in gene regulation and more recently on the Mediator complex.

Most recently, we have concentrated on the mechanisms by which this co-activator complex, which is conserved across the eukaryotic kingdom and is required for essentially all mRNA transcription, is recruited to active gene promoters.

We have also, in collaboration with Joan Curcio’s lab, investigated the role of the Mediator complex in retrotransposition of the transposable element Ty1 in yeast.

Our research employs a combination of classic and modern yeast genetic approaches along with high throughput methods, particularly chromatin immunoprecipitation followed by deep sequencing (ChIP-seq).

Please contact the corresponding author of the publications listed below for supplemental data.