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Current Support

R01 AI140726-01A1 Li (PI)

  • NIH/NIAID
  • High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungi
  • The purpose is to identify and characterize the Prp8 intein splicing inhibitors

R01AI131669-01A1 | Li (PI)

  • NIH/NIAID
  • High throughput screening of orthosteric inhibitors of flavivirus protease
  • The proposal is to develop HTS assay to screen orthosteric protease inhibitors

R21 AI133219-01 | Li (PI)

  • NIH/NIAID
  • In vivo efficacy studies of existing drugs re-purposed for flaviviruses in mouse models
  • The proposal is to investigate the in vivo efficacy of existing drugs, temoporfin and erythrosin B, re-purposed for flaviviruses in mouse models.

R21 AI134568-01 | Li (PI)

  • NIH/NIAID
  • New Use of Old Drugs for Zika Virus
  • The proposal is to investigate the in vivo efficacy of existing drugs, niclosamide and nitazoxanide, re-purposed for flaviviruses in mouse models.

R21 AI140491-01 | Li (PI)

  • NIH/NIAID
  • Identification and characterization of allosteric inhibitors of Zika protease by targeting the NS2B conformational change
  • The proposal is to develop HTS assays to screen allosteric inhibitors of Zika virus protease by targeting the NS2B conformational change.

R21 AI140406-01 | Li (PI)

  • NIH/NIAID
  • Neutralizing nanobodies as therapeutics for Dengue virus
  • The proposal is to develop neutralizing nanobodies as therapeutics for Dengue virus.

MCB-1517138 | Mills (PI), Li (subcontract-PI)

  • NSF
  • RUI: Protein Splicing and the Structure and Stability of Thermophilic Inteins
  • The RUI (Research in Undergraduate Institutions) proposal is to study the chemistry of the intein proteins from thermophilic organisms.

GM119152-01 | Hernandez (PI), Li (Co-I)

  • NIH/NIGMS
  • Coupled transitions of FK506-binding domains in molecular design and signaling
  • This proposal will structurally characterize the conformational transitions of five homologous FKBP domains by a combination of NMR techniques, X-ray crystallography, and molecular dynamics simulations.