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Li Laboratory

Research in the Li laboratory focuses on both basic and translational sciences. The majority of our projects are related to infectious disease and cancer. We develop high throughput screening assays to screen small molecule compounds as antivirals, antifungals, anti-TB, and anti-cancer. We use various biological techniques to characterize these inhibitors both in vitro and in vivo. We modify microbial organisms using genetic tools. We also determine the structures of proteins and their complexes with small molecule and/or binding partners.

Specific research interests include:

  • Development of high throughput screening assays
  • Development and characterization of small molecule inhibitors for flaviviruses
  • Development and characterization of neutralizing nanobodies against flaviviruses
  • Development and characterization of small molecule inhibitors for cryptococcal fungi
  • Development and characterization of small molecule inhibitors for mycobacteria
  • Development and characterization of small molecule inhibitors for breast cancer
  • Development of genetically modified organisms for inhibitor screening
  • Evaluation of inhibitors using in vivo animal disease models
  • Determination of structures of essential proteins and their complexes with binding partners, using crystallography, NMR, and cryo-EM

 

Join Our Laboratory!

We currently have research positions in the laboratory for a couple of postdoctoral fellows with expertise in cryo-EM and membrane protein crystallography.