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David C. Spink, Ph.D.

  • David C. Spink

    David C. Spink, Ph.D.

    • Director of the Organic and Analytical Chemistry Laboratory
    • Associate Professor, School of Public Health, Environmental Health Sciences

    • Ph.D., University of Maryland (1983)

Research Interests

Current research efforts are focused on the role of estrogens and estrogen metabolism in the genesis of breast cancer. We are investigating the effects of exposure to environmental toxicants including polychlorinated dioxins, dibenzofurans and biphenyls on cytochrome P450-catalyzed steroid and xenobiotic metabolism and evaluation of the potential roles of this metabolism in endocrine disruption and carcinogenesis. In vitro metabolic studies employ normal breast epithelial cells and breast tumor cells in culture.

Studies involve the development and application of analytical methods for metabolite identification and quantitation by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry.

Select Publications

Cao ZT, Wemm SE, Han L, Spink DC, Wulfert E.
Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry.
Anal Bioanal Chem.
Han L, Tavakoli NP, Morrissey M, Spink DC, Cao ZT.
Liquid chromatography-tandem mass spectrometry analysis of 17-hydroxyprogesterone in dried blood spots revealed matrix effect on immunoassay.
Anal Bioanal Chem.
Spink BC, Bloom MS, Wu S, Sell S, Schneider E, Ding X, Spink DC.
Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer.
Toxicol Appl Pharmacol.
Huang X, Spink DC, Schneider E, Ling H, Rai AJ, Rosano TG, Chen B, Cao ZT.
Measurement of unconjugated estriol in serum by liquid chromatography-tandem mass spectrometry and assessment of the accuracy of chemiluminescent immunoassays.
Clin Chem.
Spink BC, Bennett JA, Lostritto N, Cole JR, Spink DC.
Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells.
Mol Carcinog.