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Frank Maley, Ph.D.
Relationship of protein Structure to enzyme activity with respect to bacterial and human Thymidylate Synthases and Deoxycytidylate Deaminases using x-ray crystallography and site directed mutagenesis.
Developing systems for the high level expression of these proteins and examining the regulation of protein synthesis at the genomic and translational level.
Determining the intracellular location of Thymidylate Synthase and the effect that phosphorylation has on this process.
The role that an intron has on the expression of T4-Phage Thymidylate Synthase.
Defining the location and function of N-coupled oligosaccharides in glycoproteins using an endoglycosidase (Endo-H ) discovered in our laboratory.