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Randall H. Morse, Ph.D.

  • Randall H. Morse

    Randall H. Morse, Ph.D.

    • Transcription and Chromatin
    • Professor, School of Public Health, Biomedical Sciences

    • Ph.D., California Institute of Technology
    • Postdoctoral training: Columbia University
    • Postdoctoral training: National Institutes of Health

    randall.morse@health.ny.gov
    (518) 486-3116
    Fax: (518) 402-2299

  • Eukaryotic Transcription Initiation and the Mediator Complex
    Eukaryotic Transcription Initiation and the Mediator Complex

Research Interests

Research in the Morse laboratory has focused on basic mechanisms of eukaryotic gene regulation, using the yeast Saccharomyces cerevisiae as a tractable model for studies on the role of chromatin in gene regulation and more recently on the Mediator complex.

Most recently, we have concentrated on the mechanisms by which this co-activator complex, which is conserved across the eukaryotic kingdom and is required for essentially all mRNA transcription, is recruited to active gene promoters.

We have also, in collaboration with Joan Curcio’s lab, investigated the role of the Mediator complex in retrotransposition of the transposable element Ty1 in yeast.

Our research employs a combination of classic and modern yeast genetic approaches along with high throughput methods, particularly chromatin immunoprecipitation followed by deep sequencing (ChIP-seq).

Please contact the corresponding author of the publications listed below for supplemental data.

Select Publications

Ganapathi M, Boles NC, Charniga C, Lotz S, Campbell M, Temple S, Morse RH.
Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells.
Sci Rep.
(2018)
8
(1):
7464.
Knoll ER, Zhu ZI, Sarkar D, Landsman D, Morse RH.
Role of the pre-initiation complex in Mediator recruitment and dynamics.
Elife.
(2018)
7
pii: e3963.
Salinero AC, Knoll ER, Zhu ZI, Landsman D, Curcio MJ, Morse RH.
The Mediator co-activator complex regulates Ty1 retromobility by controlling the balance between Ty1i and Ty1 promoters.
PLoS Genet.
(2018)
14
(2):
e1007232.
Paul E, Zhu ZI, Landsman D, Morse RH.
Genome-wide association of mediator and RNA polymerase II in wild-type and mediator mutant yeast.
Mol Cell Biol.
(2015)
35
(1):
331-342.
Paul E, Tirosh I, Lai W, Buck MJ, Palumbo MJ, Morse RH.
Chromatin mediation of a transcriptional memory effect in yeast.
G3.
(2015)
5
(5):
829-38.
Ansari SA, Paul E, Sommer S, Lieleg C, He Q, Daly AZ, Rode KA, Barber WT, Ellis LC, Laporta E, Orzechowski AM, Taylor E, Reeb T, Wong J, Korber P, Morse RH.
Mediator, TATA-Binding Protein, and RNA Polymerase II contribute to low histone occupancy at active gene promoters in yeast.
J Biol Chem.
(2014)
289
(21):
14981-95.