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Zhimin (Tim) Cao, MD., Ph.D., DABCC., FAACC.

  • Zhimin (Tim) Cao

    Zhimin (Tim) Cao, MD., Ph.D., DABCC., FAACC.

    • Clinical Chemistry and Endocrinology
    • Adjunct Research Professor, University at Albany, SUNY.

    • Ph.D., University of Manitoba School of Medicine, Winnipeg, Canada
    • Postdoctoral training: University of Louisville School of Medicine, Louisville, KY

    tim.cao@health.ny.gov
    518-474-6930

Research Interests

Development and validation of liquid chromatography-mass spectrometry (LC-MS/MS)-based assays/methods have been a part of research activities within the Clinical Chemistry Laboratory. Outcomes of such activities, some were done in collaboration with colleagues at CDC and University at Albany, SUNY, led to 8 articles published in peer-reviewed scientific journals during 2017-early 2019 alone in the areas mainly including (1) analytical accuracy and precision assessment of IVD and assays for patient testing, (2) clinical laboratory quality performance evaluation via accuracy-based proficiency testing or external quality assessment, (3) identification of quality issues in analytical & post-analytical phases, (4) salivary hormone tests using LC-MS/MS methods and (5) their application in psychological research, where noninvasive detection of hormones is needed. My past research experience and interests included protein purification and characterization, gene mutation identification, production of mutant proteins via site-directed mutagenesis, and analysis of the impact of a gene mutation on the protein expression levels, structure, stability and functional properties.

Select Publications

Cao (T)Z, Botelho JC, Rej R, Vesper H, Astles RJ.
Impact of testosterone measurement standardization efforts assessed by accuracy-based proficiency testing.
Clin Biochem.
(2019)
Cao Z(T), Wemm S, Wulfert E.
Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry.
Anal Bioanal Chem.
(2019)
411
(6):
1203-10.
Han L, Tavakoli NP, Morrissey M, Spink D. Cao (T)Z.
Liquid chromatography-tandem mass spectrometry analysis of 17-hydroxyprogesterone in dried blood spots revealed matrix effect on immunoassay.
Anal Bioanal Chem.
(2019)
411
395-402.
Wemm SE, Cao Z, Han L, Wulfert E.
Stress responding and stress-related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls.
Addiction Biology.
(2018)
Cao Z, Swift TA, West CA, Rosano TG, Rej R.
Immunoassay of estradiol: unanticipated suppression by unconjugated estriol.
Clinical Chemistry.
(2004)
50
(1):
160-165.
Cao Z, Petroulakis E, Salo T, Triggs-Raine B.
Benign HEXA mutations, C739T(R247W) and C745T(R249W), cause beta-hexosaminidase A pseudodeficiency by reducing the alpha-subunit protein levels.
Journal of Biological Chemistry.
(1997)
272
(23):
14975-1498.